The use of Co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Kevin S. Eccles; Rebecca E. Deasy; László Fábián; Anita R. Maguire; Simon E. Lawrence

doi:10.1021/jo102148p

The use of Co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Kevin S. Eccles
, Rebecca E. Deasy
, László Fábián
, Anita R. Maguire
, Simon E. Lawrence

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

Original language	English
Pages (from-to)	1159-1162
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	76
Issue number	4
DOIs	https://doi.org/10.1021/jo102148p
Publication status	Published - 18 Feb 2011

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https://hdl.handle.net/10468/944Licence: CC BY-NC-ND

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abstract = "Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.",

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T2 - An alternative to salt formation

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AU - Deasy, Rebecca E.

AU - Fábián, László

AU - Maguire, Anita R.

AU - Lawrence, Simon E.

PY - 2011/2/18

Y1 - 2011/2/18

N2 - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

AB - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.

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The use of Co-crystals for the determination of absolute stereochemistry: An alternative to salt formation

Abstract

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