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Theoretical Study of Exponential Best-Fit: Modeling hCG for Gestational Trophoblastic Disease

  • Arpad Kerestely
  • , Catherine Costigan
  • , Finbarr Holland
  • , Sabin Tabirca

Research output: Chapter in Book/Report/Conference proceedingsConference proceedingpeer-review

Abstract

With the removal of the hydatidiform mole it has been shown that the human chorionic gonadotropin (hCG) hormone levels drop exponentially in women diagnosed with Gestational Trophoblastic Disease (GTD). This papers aims to introduce a new method at forecasting the decrease of the hCG levels as this could reduce the number of weekly blood test that a patient would require throughout the one year of monitoring. The hCG levels are modeled as a vertically shifted exponential curve, and this paper proposes and demonstrates a mathematical solution to finding the best parameters for this model. The method is validated using synthetic data as well as real data, and the results show that it is reliable, with decent accuracy and speed.

Original languageEnglish
Title of host publicationKnowledge Science, Engineering and Management - 14th International Conference, KSEM 2021, Proceedings
EditorsHan Qiu, Cheng Zhang, Zongming Fei, Meikang Qiu, Sun-Yuan Kung
PublisherSpringer Science and Business Media Deutschland GmbH
Pages426-438
Number of pages13
ISBN (Print)9783030821524
DOIs
Publication statusPublished - 2021
Event14th International Conference on Knowledge Science, Engineering and Management, KSEM 2021 - Tokyo, Japan
Duration: 14 Aug 202116 Aug 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12817 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference14th International Conference on Knowledge Science, Engineering and Management, KSEM 2021
Country/TerritoryJapan
CityTokyo
Period14/08/2116/08/21

Keywords

  • Data mining
  • Exponential curve fit
  • Least squares
  • Mathematical modeling

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