Abstract
Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.
| Original language | English |
|---|---|
| Pages (from-to) | 43-45 |
| Number of pages | 3 |
| Journal | Gynecologic and Obstetric Investigation |
| Volume | 54 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Polymorphism
- Pre-eclampsia
- Thrombomodulin
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