TY - JOUR
T1 - Time domain diffuse correlation spectroscopy with a high coherence pulsed source
T2 - In vivo and phantom results
AU - Pagliazzi, M.
AU - Sekar, S. Konugolu Venkata
AU - Colombo, L.
AU - Martinenghi, E.
AU - Minnema, J.
AU - Erdmann, R.
AU - Contini, D.
AU - Dalla Mora, A.
AU - Torricelli, A.
AU - Pifferi, A.
AU - Durduran, T.
N1 - Publisher Copyright:
© 2017 Optical Society of America.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Diffuse correlation spectroscopy (DCS), combined with time-resolved reflectance spectroscopy (TRS) or frequency domain spectroscopy, aims at path length (i.e. depth) resolved, non-invasive and simultaneous assessment of tissue composition and blood flow. However, while TRS provides a path length resolved data, the standard DCS does not. Recently, a time domain DCS experiment showed path length resolved measurements for improved quantification with respect to classical DCS, but was limited to phantoms and small animal studies. Here, we demonstrate time domain DCS for in vivo studies on the adult forehead and the arm. We achieve path length resolved DCS by means of an actively modelocked Ti:Sapphire laser that allows high coherence pulses, thus enabling adequate signal-tonoise ratio in relatively fast (~1 s) temporal resolution. This work paves the way to the translation of this approach to practical in vivo use.
AB - Diffuse correlation spectroscopy (DCS), combined with time-resolved reflectance spectroscopy (TRS) or frequency domain spectroscopy, aims at path length (i.e. depth) resolved, non-invasive and simultaneous assessment of tissue composition and blood flow. However, while TRS provides a path length resolved data, the standard DCS does not. Recently, a time domain DCS experiment showed path length resolved measurements for improved quantification with respect to classical DCS, but was limited to phantoms and small animal studies. Here, we demonstrate time domain DCS for in vivo studies on the adult forehead and the arm. We achieve path length resolved DCS by means of an actively modelocked Ti:Sapphire laser that allows high coherence pulses, thus enabling adequate signal-tonoise ratio in relatively fast (~1 s) temporal resolution. This work paves the way to the translation of this approach to practical in vivo use.
UR - https://www.scopus.com/pages/publications/85032797220
U2 - 10.1364/BOE.8.005311
DO - 10.1364/BOE.8.005311
M3 - Article
AN - SCOPUS:85032797220
SN - 2156-7085
VL - 8
SP - 5311
EP - 5325
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 11
M1 - #305306
ER -