Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial

Maya Hites; Eva Larranaga Lapique; Clément R. Massonnaud; Drifa Belhadi; Simon Jamard; François Goehringer; François Danion; Jean Reignier; Nathalie de Castro; Denis Garot; Karine Lacombe; Violaine Tolsma; Emmanuel Faure; Denis Malvy; Thérèse Staub; Johan Courjon; France Cazenave-Roblot; Anne Ma Dyrhol Riise; Paul Leturnier; Guillaume Martin-Blondel; Claire Roger; Karolina Akinosoglou; Vincent Le Moing; Lionel Piroth; Pierre Sellier; Xavier Lescure; Marius Trøseid; Philippe Clevenbergh; Olav Dalgard; Sébastien Gallien; Marie Gousseff; Paul Loubet; Fanny Vardon-Bounes; Clotilde Visée; Leila Belkhir; Élisabeth Botelho-Nevers; André Cabié; Anastasia Kotanidou; Fanny Lanternier; Elisabeth Rouveix-Nordon; Susana Silva; Guillaume Thiery; Pascal Poignard; Guislaine Carcelain; Alpha Diallo; Noémie Mercier; Vida Terzic; Maude Bouscambert-Duchamp; Alexandre Gaymard; Mary Anne Trabaud; Grégory Destras; Laurence Josset; Nicolas Billard; Thi Hong Lien Han; Jérémie Guedj; Sandrine Couffin-Cadiergues; Aline Dechanet; Christelle Delmas; Hélène Esperou; Claire Fougerou-Leurent; Soizic Le Mestre; Anabelle Métois; Marion Noret; Isabelle Bally; Sebastián Dergan-Dylon; Sarah Tubiana; Ouifiya Kalif; Nathalie Bergaud; Benjamin Leveau; Joe Eustace; Richard Greil; Edit Hajdu; Monika Halanova; Jose Artur Paiva; Anna Piekarska; Jesus Rodriguez Baño; Kristian Tonby; Milan Trojánek; Sotirios Tsiodras; Serhat Unal; Charles Burdet; Dominique Costagliola; Yazdan Yazdanpanah; Nathan Peiffer-Smadja; France Mentré; Florence Ader

doi:10.1016/j.jinf.2024.106120

Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial

Maya Hites
, Eva Larranaga Lapique
, Clément R. Massonnaud
, Drifa Belhadi
, Simon Jamard
, François Goehringer
, François Danion
, Jean Reignier
, Nathalie de Castro
, Denis Garot
, Karine Lacombe
, Violaine Tolsma
, Emmanuel Faure
, Denis Malvy
, Thérèse Staub
, Johan Courjon
, France Cazenave-Roblot
, Anne Ma Dyrhol Riise
, Paul Leturnier
, Guillaume Martin-Blondel

Claire Roger, Karolina Akinosoglou, Vincent Le Moing, Lionel Piroth, Pierre Sellier, Xavier Lescure, Marius Trøseid, Philippe Clevenbergh, Olav Dalgard, Sébastien Gallien, Marie Gousseff, Paul Loubet, Fanny Vardon-Bounes, Clotilde Visée, Leila Belkhir, Élisabeth Botelho-Nevers, André Cabié, Anastasia Kotanidou, Fanny Lanternier, Elisabeth Rouveix-Nordon, Susana Silva, Guillaume Thiery, Pascal Poignard, Guislaine Carcelain, Alpha Diallo, Noémie Mercier, Vida Terzic, Maude Bouscambert-Duchamp, Alexandre Gaymard, Mary Anne Trabaud, Grégory Destras, Laurence Josset, Nicolas Billard, Thi Hong Lien Han, Jérémie Guedj, Sandrine Couffin-Cadiergues, Aline Dechanet, Christelle Delmas, Hélène Esperou, Claire Fougerou-Leurent, Soizic Le Mestre, Anabelle Métois, Marion Noret, Isabelle Bally, Sebastián Dergan-Dylon, Sarah Tubiana, Ouifiya Kalif, Nathalie Bergaud, Benjamin Leveau, Joe Eustace, Richard Greil, Edit Hajdu, Monika Halanova, Jose Artur Paiva, Anna Piekarska, Jesus Rodriguez Baño, Kristian Tonby, Milan Trojánek, Sotirios Tsiodras, Serhat Unal, Charles Burdet, Dominique Costagliola, Yazdan Yazdanpanah, Nathan Peiffer-Smadja, France Mentré, Florence Ader

School of Medicine

Université libre de Bruxelles
Université Paris Cité
Centre Hospitalier Régional Universitaire de Tours
Université de Lorraine
Strasbourg University Hospital
CHU Nantes
Université de Paris Cité
Sorbonne Université
Centre Hospitalier Annecy Genevois
Center for Infection and Immunity of Lille (CIIL)
CHU Bordeaux
Center Hospitalier de Luxembourg
Université Côte d'Azur
CHU de Poitiers
University of Oslo
Hôtel-Dieu University Hospital
CHU de Toulouse
Université de Toulouse
CHU de Nîmes
University of Patras
CHU Montpellier
Université de Bourgogne
University of Bourgogne - Franche Comté
Brugmann University Hospital
Hôpital Henri Mondor
Psychiatrie Translationnelle
Centre Hospitalier Bretagne Atlantique
Université de Montpellier
Universit́e Paul Sabatier/CNRS
Centre Hospitalier Régional Mons-Hainaut
Université catholique de Louvain
CHU de Saint-Étienne
Universite Jean Monnet Saint-Etienne
Institut national de la santé et de la recherche médicale
Centre Hospitalier Universitaire de Fort de France
National and Kapodistrian University of Athens
Hôpital Ambroise Paré
University of Porto
Medical Intensive Care Unit
Université Grenoble Alpes
CHU de Grenoble
Assistance publique – Hôpitaux de Paris
Maladies Infectieuses Emergentes
Hospices civils de Lyon
Université Claude Bernard Lyon 1
Hôpital de la Croix-Rousse
CHU de Rennes
RENARCI
Paracelsus Private Medical University
Cancer Cluster Salzburg
AGMT
University of Szeged
Pavol Jozef Šafárik University
Centro Hospitalar Universitário de São João
Medical University of Łódź
Hospital Universitario Virgen Macarena
Charles University
Attikon University Hospital
Hacettepe University
National Institute for Health and Care Research
Universite Claude Bernard Lyon 1

Research output: Contribution to journal › Letter › peer-review

Original language	English
Article number	106120
Journal	Journal of Infection
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.jinf.2024.106120
Publication status	Published - Mar 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jinf.2024.106120

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Hites, M., Lapique, E. L., Massonnaud, C. R., Belhadi, D., Jamard, S., Goehringer, F., Danion, F., Reignier, J., de Castro, N., Garot, D., Lacombe, K., Tolsma, V., Faure, E., Malvy, D., Staub, T., Courjon, J., Cazenave-Roblot, F., Dyrhol Riise, A. M., Leturnier, P., ... Ader, F. (2024). Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial. Journal of Infection, 88(3), Article 106120. https://doi.org/10.1016/j.jinf.2024.106120

@article{7ebd377e7faa49a2bd2d2cd9211515ac,

title = "Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial",

author = "Maya Hites and Lapique, \{Eva Larranaga\} and Massonnaud, \{Cl{\'e}ment R.\} and Drifa Belhadi and Simon Jamard and Fran{\c c}ois Goehringer and Fran{\c c}ois Danion and Jean Reignier and \{de Castro\}, Nathalie and Denis Garot and Karine Lacombe and Violaine Tolsma and Emmanuel Faure and Denis Malvy and Th{\'e}r{\`e}se Staub and Johan Courjon and France Cazenave-Roblot and \{Dyrhol Riise\}, \{Anne Ma\} and Paul Leturnier and Guillaume Martin-Blondel and Claire Roger and Karolina Akinosoglou and Moing, \{Vincent Le\} and Lionel Piroth and Pierre Sellier and Xavier Lescure and Marius Tr{\o}seid and Philippe Clevenbergh and Olav Dalgard and S{\'e}bastien Gallien and Marie Gousseff and Paul Loubet and Fanny Vardon-Bounes and Clotilde Vis{\'e}e and Leila Belkhir and {\'E}lisabeth Botelho-Nevers and Andr{\'e} Cabi{\'e} and Anastasia Kotanidou and Fanny Lanternier and Elisabeth Rouveix-Nordon and Susana Silva and Guillaume Thiery and Pascal Poignard and Guislaine Carcelain and Alpha Diallo and No{\'e}mie Mercier and Vida Terzic and Maude Bouscambert-Duchamp and Alexandre Gaymard and Trabaud, \{Mary Anne\} and Gr{\'e}gory Destras and Laurence Josset and Nicolas Billard and Han, \{Thi Hong Lien\} and J{\'e}r{\'e}mie Guedj and Sandrine Couffin-Cadiergues and Aline Dechanet and Christelle Delmas and H{\'e}l{\`e}ne Esperou and Claire Fougerou-Leurent and Mestre, \{Soizic Le\} and Anabelle M{\'e}tois and Marion Noret and Isabelle Bally and Sebasti{\'a}n Dergan-Dylon and Sarah Tubiana and Ouifiya Kalif and Nathalie Bergaud and Benjamin Leveau and Joe Eustace and Richard Greil and Edit Hajdu and Monika Halanova and Paiva, \{Jose Artur\} and Anna Piekarska and \{Rodriguez Ba{\~n}o\}, Jesus and Kristian Tonby and Milan Troj{\'a}nek and Sotirios Tsiodras and Serhat Unal and Charles Burdet and Dominique Costagliola and Yazdan Yazdanpanah and Nathan Peiffer-Smadja and France Mentr{\'e} and Florence Ader",

year = "2024",

month = mar,

doi = "10.1016/j.jinf.2024.106120",

language = "English",

volume = "88",

journal = "Journal of Infection",

issn = "0163-4453",

publisher = "W.B. Saunders Ltd",

number = "3",

}

Hites, M, Lapique, EL, Massonnaud, CR, Belhadi, D, Jamard, S, Goehringer, F, Danion, F, Reignier, J, de Castro, N, Garot, D, Lacombe, K, Tolsma, V, Faure, E, Malvy, D, Staub, T, Courjon, J, Cazenave-Roblot, F, Dyrhol Riise, AM, Leturnier, P, Martin-Blondel, G, Roger, C, Akinosoglou, K, Moing, VL, Piroth, L, Sellier, P, Lescure, X, Trøseid, M, Clevenbergh, P, Dalgard, O, Gallien, S, Gousseff, M, Loubet, P, Vardon-Bounes, F, Visée, C, Belkhir, L, Botelho-Nevers, É, Cabié, A, Kotanidou, A, Lanternier, F, Rouveix-Nordon, E, Silva, S, Thiery, G, Poignard, P, Carcelain, G, Diallo, A, Mercier, N, Terzic, V, Bouscambert-Duchamp, M, Gaymard, A, Trabaud, MA, Destras, G, Josset, L, Billard, N, Han, THL, Guedj, J, Couffin-Cadiergues, S, Dechanet, A, Delmas, C, Esperou, H, Fougerou-Leurent, C, Mestre, SL, Métois, A, Noret, M, Bally, I, Dergan-Dylon, S, Tubiana, S, Kalif, O, Bergaud, N, Leveau, B, Eustace, J, Greil, R, Hajdu, E, Halanova, M, Paiva, JA, Piekarska, A, Rodriguez Baño, J, Tonby, K, Trojánek, M, Tsiodras, S, Unal, S, Burdet, C, Costagliola, D, Yazdanpanah, Y, Peiffer-Smadja, N, Mentré, F & Ader, F 2024, 'Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial', Journal of Infection, vol. 88, no. 3, 106120. https://doi.org/10.1016/j.jinf.2024.106120

TY - JOUR

T1 - Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy)

T2 - A phase 3, randomized, double-blind, placebo-controlled trial

AU - Hites, Maya

AU - Lapique, Eva Larranaga

AU - Massonnaud, Clément R.

AU - Belhadi, Drifa

AU - Jamard, Simon

AU - Goehringer, François

AU - Danion, François

AU - Reignier, Jean

AU - de Castro, Nathalie

AU - Garot, Denis

AU - Lacombe, Karine

AU - Tolsma, Violaine

AU - Faure, Emmanuel

AU - Malvy, Denis

AU - Staub, Thérèse

AU - Courjon, Johan

AU - Cazenave-Roblot, France

AU - Dyrhol Riise, Anne Ma

AU - Leturnier, Paul

AU - Martin-Blondel, Guillaume

AU - Roger, Claire

AU - Akinosoglou, Karolina

AU - Moing, Vincent Le

AU - Piroth, Lionel

AU - Sellier, Pierre

AU - Lescure, Xavier

AU - Trøseid, Marius

AU - Clevenbergh, Philippe

AU - Dalgard, Olav

AU - Gallien, Sébastien

AU - Gousseff, Marie

AU - Loubet, Paul

AU - Vardon-Bounes, Fanny

AU - Visée, Clotilde

AU - Belkhir, Leila

AU - Botelho-Nevers, Élisabeth

AU - Cabié, André

AU - Kotanidou, Anastasia

AU - Lanternier, Fanny

AU - Rouveix-Nordon, Elisabeth

AU - Silva, Susana

AU - Thiery, Guillaume

AU - Poignard, Pascal

AU - Carcelain, Guislaine

AU - Diallo, Alpha

AU - Mercier, Noémie

AU - Terzic, Vida

AU - Bouscambert-Duchamp, Maude

AU - Gaymard, Alexandre

AU - Trabaud, Mary Anne

AU - Destras, Grégory

AU - Josset, Laurence

AU - Billard, Nicolas

AU - Han, Thi Hong Lien

AU - Guedj, Jérémie

AU - Couffin-Cadiergues, Sandrine

AU - Dechanet, Aline

AU - Delmas, Christelle

AU - Esperou, Hélène

AU - Fougerou-Leurent, Claire

AU - Mestre, Soizic Le

AU - Métois, Anabelle

AU - Noret, Marion

AU - Bally, Isabelle

AU - Dergan-Dylon, Sebastián

AU - Tubiana, Sarah

AU - Kalif, Ouifiya

AU - Bergaud, Nathalie

AU - Leveau, Benjamin

AU - Eustace, Joe

AU - Greil, Richard

AU - Hajdu, Edit

AU - Halanova, Monika

AU - Paiva, Jose Artur

AU - Piekarska, Anna

AU - Rodriguez Baño, Jesus

AU - Tonby, Kristian

AU - Trojánek, Milan

AU - Tsiodras, Sotirios

AU - Unal, Serhat

AU - Burdet, Charles

AU - Costagliola, Dominique

AU - Yazdanpanah, Yazdan

AU - Peiffer-Smadja, Nathan

AU - Mentré, France

AU - Ader, Florence

PY - 2024/3

Y1 - 2024/3

UR - https://www.scopus.com/pages/publications/85186493063

U2 - 10.1016/j.jinf.2024.106120

DO - 10.1016/j.jinf.2024.106120

M3 - Letter

C2 - 38367705

AN - SCOPUS:85186493063

SN - 0163-4453

VL - 88

JO - Journal of Infection

JF - Journal of Infection

IS - 3

M1 - 106120

ER -

Tixagevimab-cilgavimab (AZD7442) for the treatment of patients hospitalized with COVID-19 (DisCoVeRy): A phase 3, randomized, double-blind, placebo-controlled trial

UN SDGs

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