Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine

Raymond G. Kelly; Kenneth Nally; Fergus Shanahan; Joe O'Connell

doi:10.1111/j.1749-6632.2002.tb04700.x

Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine

Raymond G. Kelly
, Kenneth Nally
, Fergus Shanahan
, Joe O'Connell

University College Cork

Research output: Contribution to journal › Article › peer-review

Abstract

Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adeno-carcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.

Original language	English
Pages (from-to)	555-558
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	973
DOIs	https://doi.org/10.1111/j.1749-6632.2002.tb04700.x
Publication status	Published - 2002

Keywords

Colon
Epithelial cells
N-Acetyl-L-cysteine (NAC)
Type I insulin-like growth factor receptor (IGF-IR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1749-6632.2002.tb04700.x

Cite this

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title = "Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine",

abstract = "Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adeno-carcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.",

keywords = "Colon, Epithelial cells, N-Acetyl-L-cysteine (NAC), Type I insulin-like growth factor receptor (IGF-IR)",

author = "Kelly, \{Raymond G.\} and Kenneth Nally and Fergus Shanahan and Joe O'Connell",

year = "2002",

doi = "10.1111/j.1749-6632.2002.tb04700.x",

language = "English",

volume = "973",

pages = "555--558",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "John Wiley and Sons Inc",

}

Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine. / Kelly, Raymond G.; Nally, Kenneth; Shanahan, Fergus et al.
In: Annals of the New York Academy of Sciences, Vol. 973, 2002, p. 555-558.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine

AU - Kelly, Raymond G.

AU - Nally, Kenneth

AU - Shanahan, Fergus

AU - O'Connell, Joe

PY - 2002

Y1 - 2002

N2 - Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adeno-carcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.

AB - Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-1R on three colorectal adeno-carcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.

KW - Colon

KW - Epithelial cells

KW - N-Acetyl-L-cysteine (NAC)

KW - Type I insulin-like growth factor receptor (IGF-IR)

UR - https://www.scopus.com/pages/publications/0036961941

U2 - 10.1111/j.1749-6632.2002.tb04700.x

DO - 10.1111/j.1749-6632.2002.tb04700.x

M3 - Article

C2 - 12485928

AN - SCOPUS:0036961941

SN - 0077-8923

VL - 973

SP - 555

EP - 558

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine

Abstract

Keywords

UN SDGs

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