Use of nonlinear upconverting nanoparticles provides increased spatial resolution in fluorescence diffuse imaging

Pontus Svenmarker; Can T. Xu; Stefan Andersson-Engels

doi:10.1364/OL.35.002789

Use of nonlinear upconverting nanoparticles provides increased spatial resolution in fluorescence diffuse imaging

Pontus Svenmarker
, Can T. Xu
, Stefan Andersson-Engels

Lund University

Research output: Contribution to journal › Article › peer-review

Abstract

Fluorescence diffuse imaging (FDI) suffers from limited spatial resolution. In this Letter, we report a scanning imaging approach to increase the resolution of FDI using nonlinear fluorophores, The resolution of a linear fluorophore was compared with nonlinear upconverting nanoparticles (NaYF ₄:Yb³⁺/Tm³⁺) in a tissue phantom. A resolution improvement of a factor of 1.3 was found experimentally. Simulations suggested a maximum resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores is a promising method for increasing the spatial resolution in FDI.

Original language	English
Pages (from-to)	2789-2791
Number of pages	3
Journal	Optics Letters
Volume	35
Issue number	16
DOIs	https://doi.org/10.1364/OL.35.002789
Publication status	Published - 15 Aug 2010
Externally published	Yes

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abstract = "Fluorescence diffuse imaging (FDI) suffers from limited spatial resolution. In this Letter, we report a scanning imaging approach to increase the resolution of FDI using nonlinear fluorophores, The resolution of a linear fluorophore was compared with nonlinear upconverting nanoparticles (NaYF 4:Yb3+/Tm3+) in a tissue phantom. A resolution improvement of a factor of 1.3 was found experimentally. Simulations suggested a maximum resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores is a promising method for increasing the spatial resolution in FDI.",

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AU - Andersson-Engels, Stefan

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N2 - Fluorescence diffuse imaging (FDI) suffers from limited spatial resolution. In this Letter, we report a scanning imaging approach to increase the resolution of FDI using nonlinear fluorophores, The resolution of a linear fluorophore was compared with nonlinear upconverting nanoparticles (NaYF 4:Yb3+/Tm3+) in a tissue phantom. A resolution improvement of a factor of 1.3 was found experimentally. Simulations suggested a maximum resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores is a promising method for increasing the spatial resolution in FDI.

AB - Fluorescence diffuse imaging (FDI) suffers from limited spatial resolution. In this Letter, we report a scanning imaging approach to increase the resolution of FDI using nonlinear fluorophores, The resolution of a linear fluorophore was compared with nonlinear upconverting nanoparticles (NaYF 4:Yb3+/Tm3+) in a tissue phantom. A resolution improvement of a factor of 1.3 was found experimentally. Simulations suggested a maximum resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores is a promising method for increasing the spatial resolution in FDI.

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JO - Optics Letters

JF - Optics Letters

IS - 16

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Use of nonlinear upconverting nanoparticles provides increased spatial resolution in fluorescence diffuse imaging

Abstract

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