Vagus nerve stimulation for the management of immune-mediated inflammatory diseases

Jessica Tarn; Ines Figueiredo Pinto; Wan Fai Ng

doi:10.1016/B978-0-12-816996-4.00026-5

Vagus nerve stimulation for the management of immune-mediated inflammatory diseases

Jessica Tarn
, Ines Figueiredo Pinto
, Wan Fai Ng

HRB Clinical Research Facility

Newcastle University
Hospital Curry Cabral
Polytechnic Institute of Lisbon
Egas Moniz School of Health & Science
Newcastle upon Tyne Hospitals NHS Foundation Trust

Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review

Abstract

The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.

Original language	English
Title of host publication	Vagus Nerve Stimulation
Publisher	Elsevier
Pages	275-286
Number of pages	12
ISBN (Electronic)	9780128169964
ISBN (Print)	9780128169971
DOIs	https://doi.org/10.1016/B978-0-12-816996-4.00026-5
Publication status	Published - 1 Jan 2024

Keywords

immune-mediated inflammatory disease
neuroimmune modulation
Vagus nerve

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10.1016/B978-0-12-816996-4.00026-5

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abstract = "The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.",

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AU - Ng, Wan Fai

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N2 - The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.

AB - The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.

KW - immune-mediated inflammatory disease

KW - neuroimmune modulation

KW - Vagus nerve

UR - https://www.scopus.com/pages/publications/85212892444

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DO - 10.1016/B978-0-12-816996-4.00026-5

M3 - Chapter

AN - SCOPUS:85212892444

SN - 9780128169971

SP - 275

EP - 286

BT - Vagus Nerve Stimulation

PB - Elsevier

ER -

Vagus nerve stimulation for the management of immune-mediated inflammatory diseases

Abstract

Keywords

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