TY - CHAP
T1 - Vagus nerve stimulation for the management of immune-mediated inflammatory diseases
AU - Tarn, Jessica
AU - Pinto, Ines Figueiredo
AU - Ng, Wan Fai
N1 - Publisher Copyright:
© 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.
AB - The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic-pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.
KW - immune-mediated inflammatory disease
KW - neuroimmune modulation
KW - Vagus nerve
UR - https://www.scopus.com/pages/publications/85212892444
U2 - 10.1016/B978-0-12-816996-4.00026-5
DO - 10.1016/B978-0-12-816996-4.00026-5
M3 - Chapter
AN - SCOPUS:85212892444
SN - 9780128169971
SP - 275
EP - 286
BT - Vagus Nerve Stimulation
PB - Elsevier
ER -