Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Simon L. Barry; Emer Lynch; Philip Bredin; Sebastian McWilliams; Julie McCarthy; Orla O’Mahony; Linda Feeley; Killian Nugent; Patrick Sheahan; Deirdre O’Hanlon; David O’Reilly; Seamus O’Reilly

doi:10.3390/onco4040030

Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Simon L. Barry
, Emer Lynch
, Philip Bredin
, Sebastian McWilliams
, Julie McCarthy
, Orla O’Mahony
, Linda Feeley
, Killian Nugent
, Patrick Sheahan
, Deirdre O’Hanlon
, David O’Reilly
, Seamus O’Reilly

School of Medicine

Cork University Hospital
South Infirmary Victoria University Hospital
Beaumont Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.

Original language	English
Pages (from-to)	427-438
Number of pages	12
Journal	Onco
Volume	4
Issue number	4
DOIs	https://doi.org/10.3390/onco4040030
Publication status	Published - Jan 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anaplastic thyroid cancer
Astrobiology
Biology
Cancer
Guideline
Internal medicine
Materials science
Medicine
Metallurgy
Oncology
Pathology
Perforation
Punching
Refractory (planetary science)
Targeted therapy
Thyroid
Thyroid cancer

Access to Document

10.3390/onco4040030

Cite this

@article{b95005a152334b179c19b73e23b8f581,

title = "Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas",

abstract = "Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.",

keywords = "Anaplastic thyroid cancer, Astrobiology, Biology, Cancer, Guideline, Internal medicine, Materials science, Medicine, Metallurgy, Oncology, Pathology, Perforation, Punching, Refractory (planetary science), Targeted therapy, Thyroid, Thyroid cancer",

author = "Barry, \{Simon L.\} and Emer Lynch and Philip Bredin and Sebastian McWilliams and Julie McCarthy and Orla O{\textquoteright}Mahony and Linda Feeley and Killian Nugent and Patrick Sheahan and Deirdre O{\textquoteright}Hanlon and David O{\textquoteright}Reilly and Seamus O{\textquoteright}Reilly",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = jan,

doi = "10.3390/onco4040030",

language = "English",

volume = "4",

pages = "427--438",

journal = "Onco",

issn = "2673-7523",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

TY - JOUR

T1 - Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

AU - Barry, Simon L.

AU - Lynch, Emer

AU - Bredin, Philip

AU - McWilliams, Sebastian

AU - McCarthy, Julie

AU - O’Mahony, Orla

AU - Feeley, Linda

AU - Nugent, Killian

AU - Sheahan, Patrick

AU - O’Hanlon, Deirdre

AU - O’Reilly, David

AU - O’Reilly, Seamus

PY - 2024/1

Y1 - 2024/1

N2 - Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.

AB - Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.

KW - Anaplastic thyroid cancer

KW - Astrobiology

KW - Biology

KW - Cancer

KW - Guideline

KW - Internal medicine

KW - Materials science

KW - Medicine

KW - Metallurgy

KW - Oncology

KW - Pathology

KW - Perforation

KW - Punching

KW - Refractory (planetary science)

KW - Targeted therapy

KW - Thyroid

KW - Thyroid cancer

UR - https://www.mendeley.com/catalogue/083ebf12-f758-30c3-a38b-3e84229552da/

U2 - 10.3390/onco4040030

DO - 10.3390/onco4040030

M3 - Article

SN - 2673-7523

VL - 4

SP - 427

EP - 438

JO - Onco

JF - Onco

IS - 4

ER -

Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Abstract

UN SDGs

Keywords

Access to Document

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Research from Cork University Hospital Yields New Study Findings on Thyroid Cancer (Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas)

Cite this

Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Press/Media

Research from Cork University Hospital Yields New Study Findings on Thyroid Cancer (Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas)

Cite this