What goes around comes around: Novel pharmacological targets in the gut-brain axis

Camila González-Arancibia; Jorge Escobar-Luna; Camila Barrera-Bugueño; Camilo Díaz-Zepeda; María P. González-Toro; Loreto Olavarría-Ramírez; Francesca Zanelli-Massai; Martin Gotteland; Javier A. Bravo; Marcela Julio-Pieper

doi:10.1177/1756283X16630718

What goes around comes around: Novel pharmacological targets in the gut-brain axis

Camila González-Arancibia
, Jorge Escobar-Luna
, Camila Barrera-Bugueño
, Camilo Díaz-Zepeda
, María P. González-Toro
, Loreto Olavarría-Ramírez
, Francesca Zanelli-Massai
, Martin Gotteland
, Javier A. Bravo
, Marcela Julio-Pieper

Pontificia Universidad Católica de Valparaíso
Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

Abstract

The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

Original language	English
Pages (from-to)	339-353
Number of pages	15
Journal	Therapeutic Advances in Gastroenterology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1177/1756283X16630718
Publication status	Published - 2016
Externally published	Yes

Keywords

enteric nervous system
gut-brain axis
interleukin 22
intestinal microbiota
serotonin
vagus nerve

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10.1177/1756283X16630718

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González-Arancibia, C., Escobar-Luna, J., Barrera-Bugueño, C., Díaz-Zepeda, C., González-Toro, M. P., Olavarría-Ramírez, L., Zanelli-Massai, F., Gotteland, M., Bravo, J. A., & Julio-Pieper, M. (2016). What goes around comes around: Novel pharmacological targets in the gut-brain axis. Therapeutic Advances in Gastroenterology, 9(3), 339-353. https://doi.org/10.1177/1756283X16630718

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title = "What goes around comes around: Novel pharmacological targets in the gut-brain axis",

abstract = "The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.",

keywords = "enteric nervous system, gut-brain axis, interleukin 22, intestinal microbiota, serotonin, vagus nerve",

author = "Camila Gonz{\'a}lez-Arancibia and Jorge Escobar-Luna and Camila Barrera-Bugue{\~n}o and Camilo D{\'i}az-Zepeda and Gonz{\'a}lez-Toro, \{Mar{\'i}a P.\} and Loreto Olavarr{\'i}a-Ram{\'i}rez and Francesca Zanelli-Massai and Martin Gotteland and Bravo, \{Javier A.\} and Marcela Julio-Pieper",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

doi = "10.1177/1756283X16630718",

language = "English",

volume = "9",

pages = "339--353",

journal = "Therapeutic Advances in Gastroenterology",

issn = "1756-283X",

publisher = "SAGE Publications Ltd",

number = "3",

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González-Arancibia, C, Escobar-Luna, J, Barrera-Bugueño, C, Díaz-Zepeda, C, González-Toro, MP, Olavarría-Ramírez, L, Zanelli-Massai, F, Gotteland, M, Bravo, JA & Julio-Pieper, M 2016, 'What goes around comes around: Novel pharmacological targets in the gut-brain axis', Therapeutic Advances in Gastroenterology, vol. 9, no. 3, pp. 339-353. https://doi.org/10.1177/1756283X16630718

TY - JOUR

T1 - What goes around comes around

T2 - Novel pharmacological targets in the gut-brain axis

AU - González-Arancibia, Camila

AU - Escobar-Luna, Jorge

AU - Barrera-Bugueño, Camila

AU - Díaz-Zepeda, Camilo

AU - González-Toro, María P.

AU - Olavarría-Ramírez, Loreto

AU - Zanelli-Massai, Francesca

AU - Gotteland, Martin

AU - Bravo, Javier A.

AU - Julio-Pieper, Marcela

PY - 2016

Y1 - 2016

N2 - The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

AB - The gut and the brain communicate bidirectionally through anatomic and humoral pathways, establishing what is known as the gut-brain axis. Therefore, interventions affecting one system will impact on the other, giving the opportunity to investigate and develop future therapeutic strategies that target both systems. Alterations in the gut-brain axis may arise as a consequence of changes in microbiota composition (dysbiosis), modifications in intestinal barrier function, impairment of enteric nervous system, unbalanced local immune response and exaggerated responses to stress, to mention a few. In this review we analyze and discuss several novel pharmacological targets within the gut-brain axis, with potential applications to improve intestinal and mental health.

KW - enteric nervous system

KW - gut-brain axis

KW - interleukin 22

KW - intestinal microbiota

KW - serotonin

KW - vagus nerve

UR - https://www.scopus.com/pages/publications/84963762016

U2 - 10.1177/1756283X16630718

DO - 10.1177/1756283X16630718

M3 - Review article

AN - SCOPUS:84963762016

SN - 1756-283X

VL - 9

SP - 339

EP - 353

JO - Therapeutic Advances in Gastroenterology

JF - Therapeutic Advances in Gastroenterology

IS - 3

ER -

What goes around comes around: Novel pharmacological targets in the gut-brain axis

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Keywords

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