Biography

EDUCATION:
1997 - Ph.D. (Biochemistry and Immunology), Moscow State University, Russia. Thesis title: "Diagnostics of C. trachomatis by PCR and evaluation of the parameters of the immune and interferon status in urogenital chlamydiosis".
1992 - M.Sc. (Biology), Moscow State University, Russia. Thesis title: "Development of the procedure of diagnostics of herpes simplex virus and chlamydiosis in clinical samples using DNA-hybridization and PCR".

EMPLOYMENT:
2023-present: Technical Officer, iEd Hub and School of Pharmacy, UCC
2022-2023: Technical Officer, School of Biochemistry and Cell Biology, UCC
2013-2022: Research Support Officer, Laboratory of Biophysical Analysis, School of Biochemistry and Cell Biology, UCC
2008–2013: Senior Postdoctoral Researcher, Laboratory of Biophysical Analysis, Biochemistry Department, UCC
2006–2008: Postdoctoral Researcher, Laboratory of Biophysical Analysis, Biochemistry Department, UCC
2004–2006: Postdoctoral Researcher, Mol. Cell. Biol. Laboratory, Biochemistry Department, University College Cork (UCC), Cork, Ireland
2003–2004: Postdoctoral Researcher, Institute of Physiology, Otto-von-Guericke University, Magdeburg, Germany
1996–2003: Postdoctoral Researcher, Research Centre for Obstetrics, Gynaecology and Perinatology, Moscow, Russia

Research Interests

- Monoclonal antibody production, purification and characterisation
- Cell-based antibody potency assays
- Mitochondrial function
- Cell metabolism and bioenergetics in normoxia and hypoxia
- Calcium signalling
- Cancer cell metabolism, effects of oncometabolites of mitochondrial function and epigenetics Ischemia, - HIF signalling, HIF-independent responses to hypoxia and metabolic stress (APMK, translation remodelling)
- Development of phosphorescence-based techniques for O2 imaging in cells, spheroids and living tissues
- Monitoring and modelling of cell oxygenation and O2 gradients in (patho)-physiological conditions
- Confocal and 2-photon fluorescent microscopy, live cell / tissue imaging

Book Chapters

  Year Publication
(2018) 'CHAPTER 11: Imaging of Tissue Oxygen Ex vivo'
Zhdanov A.;Papkovsky D. (2018) 'CHAPTER 11: Imaging of Tissue Oxygen Ex vivo' In: Quenched-phosphorescence Detection of Molecular Oxygen: Applications in Life Sciences. London: The Royal Society of Chemistry. [DOI] [Details]
(2015) 'Cell Energy Budget Platform for Assessment of Cell Metabolism'
Papkovsky DB and Zhdanov AV (2015) 'Cell Energy Budget Platform for Assessment of Cell Metabolism' In: Mitochondrial Medicine, Methods in Molecular Biology. Springer New York: Springer New York. [ Publisher's Version] [Details]
(2012) 'O2 Analysis on a Fluorescence Spectrometer or Plate Reader'
Zhdanov AV, Hynes J, Dmitriev RI and Papkovsky DB (2012) 'O2 Analysis on a Fluorescence Spectrometer or Plate Reader' In: Phosphorescent Oxygen-Sensitive Probes. Basel, Switzerland: Springer Basel. [Details]
(2012) 'O2 Imaging in Biological Specimens'
Fercher A, Zhdanov AV and Papkovsky DB (2012) 'O2 Imaging in Biological Specimens' In: Phosphorescent Oxygen-Sensitive Probes. Basel, Switzerland: Springer Basel. [Details]
(2010) 'Imaging of Cellular Oxygen and Analysis of Metabolic Responses of Mammalian Cells'
Fercher A, O’Riordan TC, Zhdanov AV, Dmitriev RI and Papkovsky DB (2010) 'Imaging of Cellular Oxygen and Analysis of Metabolic Responses of Mammalian Cells' In: Dmitri B. Papkovsky (eds). Live Cell Imaging. New York, USA: Humana Press. [Details]

Peer Reviewed Journals

  Year Publication
(2025) 'Optical sensor-based systems for the analysis of cell metabolism and bioenergetics'
Liang Li and Alexander V. Zhdanov and Dmitri B. Papkovsky (2025) 'Optical sensor-based systems for the analysis of cell metabolism and bioenergetics'. Sensors And Actuators B: Chemical, 429 [ Publisher's Version] [DOI] [Details]
(2023) 'Analysis of tumour oxygenation in model animals on a phosphorescence lifetime based macro-imager'
Zhdanov AV;Sen R;Devoy C;Li L;Tangney M;Papkovsky DB; (2023) 'Analysis of tumour oxygenation in model animals on a phosphorescence lifetime based macro-imager'. Scientific Reports, 13 (1) [DOI] [Details]
(2023) 'Fluorescence Lifetime Macro Imager for Biomedical Applications'
Sen R;Zhdanov AV;Devoy C;Tangney M;Hirvonen LM;Nomerotski A;Papkovsky DB; (2023) 'Fluorescence Lifetime Macro Imager for Biomedical Applications'. Journal of visualized experiments : JoVE, (194) [DOI] [Details]
(2023) 'Combining the oxygen sensor based respirometry and 16S rRNA amplicon sequencing for the analysis of microbiota in commercial mince products'
Elisseeva S;Bastiaanssen TFS;Santovito E;Zhdanov AV;Cryan JF;Kerry JP;Papkovsky DB; (2023) 'Combining the oxygen sensor based respirometry and 16S rRNA amplicon sequencing for the analysis of microbiota in commercial mince products'. Meat Science, 205 [DOI] [Details]
(2022) 'Advanced multimodal solid-state optochemical pH and dual pH/O2 sensors for cell analysis'
Liang Li and Alexander V. Zhdanov and Dmitri B. Papkovsky (2022) 'Advanced multimodal solid-state optochemical pH and dual pH/O2 sensors for cell analysis'. Sensors And Actuators B: Chemical, 371 [ Publisher's Version] [DOI] [Details]
(2022) 'Heterosubstituted Derivatives of PtPFPP for O2 Sensing and Cell Analysis: Structure-Activity Relationships'
Zanetti, C;Gaspar, RD;Zhdanov, AV;Maguire, NM;Joyce, SA;Collins, SG;Maguire, AR;Papkovsky, DB (2022) 'Heterosubstituted Derivatives of PtPFPP for O2 Sensing and Cell Analysis: Structure-Activity Relationships'. Bioconjugate Chemistry, [DOI] [Details]
(2022) 'Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells'
Uchenunu, O;Zhdanov, AV;Hutton, P;Jovanovic, P;Wang, Y;Andreev, DE;Hulea, L;Papadopoli, DJ;Avizonis, D;Baranov, PV;Pollak, MN;Papkovsky, DB;Topisirovic, I (2022) 'Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells'. Febs Open Bio, 12 :959-982 [DOI] [Details]
(2022) 'Phosphorescence lifetime measurements with sensor materials: Comparison of the four different detection platforms'
Rajannya Sen and Liang Li and Alexander V. Zhdanov and Rafael D.L. Gaspar and Dmitri B. Papkovsky (2022) 'Phosphorescence lifetime measurements with sensor materials: Comparison of the four different detection platforms'. Sensors And Actuators B: Chemical, 371 [ Publisher's Version] [DOI] [Details]
(2022) 'Advanced multi-modal, multi-analyte optochemical sensing platform for cell analysis'
Alexander V. Zhdanov and Liang Li and Panpan Yang and Alena O. Shkirdova and Shuze Tang and Dmitri V. Yashunsky and Gelii V. Ponomarev and Ilya A. Zamilatskov and Dmitri B. Papkovsky (2022) 'Advanced multi-modal, multi-analyte optochemical sensing platform for cell analysis'. Sensors And Actuators B: Chemical, 355 [ Publisher's Version] [DOI] [Details]
(2022) 'Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis'
Zhdanov AV;Golubeva AV;Yordanova MM;Andreev DE;Ventura-Silva AP;Schellekens H;Baranov PV;Cryan JF;Papkovsky DB; (2022) 'Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis'. Cellular and Molecular Life Sciences, 79 (8) [DOI] [Details]
(2021) 'Cell Energy Budget Platform for Multiparametric Assessment of Cell and Tissue Metabolism'
Papkovsky DB;Zhdanov AV; (2021) 'Cell Energy Budget Platform for Multiparametric Assessment of Cell and Tissue Metabolism'. Methods in molecular biology (Clifton, N.J.), 2276 [DOI] [Details]
(2021) 'Multi-Spectral Clinical Prototype for Fluorophore Detection'
Grygoryev, Konstantin and Lu, Huihui and Li, Celina L. and Zhdanov, Alexander V. and Burke, Ray and Andersson-Engels, Stefan (2021) 'Multi-Spectral Clinical Prototype for Fluorophore Detection'. Frontiers in Physics, 9 [ Publisher's Version] [DOI] [Details]
(2021) 'The gut microbiome influences the bioavailability of olanzapine in rats'
Cussotto, Sofia; Walsh, Jacinta; Golubeva, Anna V.; Zhdanov, Alexander V.; Strain, Conall R.; Fouhy, Fiona; Stanton, Catherine; Dinan, Timothy G.; Hyland, Niall P.; Clarke, Gerard; Cryan, John F.; Griffin, Brendan T. (2021) 'The gut microbiome influences the bioavailability of olanzapine in rats'. Ebiomedicine, 66 [DOI] [Full Text] [Details]
(2020) 'Mapping O-2 concentration in ex-vivo tissue samples on a fast PLIM macro-imager'
Sen, R;Zhdanov, AV;Bastiaanssen, TFS;Hirvonen, LM;Svihra, P;Fitzgerald, P;Cryan, JF;Andersson-Engels, S;Nomerotski, A;Papkovsky, DB (2020) 'Mapping O-2 concentration in ex-vivo tissue samples on a fast PLIM macro-imager'. Scientific Reports, 10 [DOI] [Details]
(2020) 'New luminescence lifetime macro-imager based on a Tpx3Cam optical camera'
Sen R.;Hirvonen L.;Zhdanov A.;Svihra P.;Andersson-Engels S.;Nomerotski A.;Papkovsky D. (2020) 'New luminescence lifetime macro-imager based on a Tpx3Cam optical camera'. Biomedical optics express, 11 (1):77-88 [DOI] [Details]
(2020) 'Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context'
Benitez-Cantos, Maria S.; Yordanova, Martina M.; O'Connor, Patrick B. F.; Zhdanov, Alexander V.; Kovalchuk, Sergey I.; Papkovsky, Dmitri B.; Andreev, Dmitry E.; Baranov, Pavel V. (2020) 'Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context'. Genome Research, 30 (7):974-984 [DOI] [Full Text] [Details]
(2020) 'Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF'
Loughran, G;Zhdanov, AV;Mikhaylova, MS;Rozov, FN;Datskevich, PN;Kovalchuk, SI;Serebryakova, MV;Kiniry, SJ;Michel, AM;O'Connor, PBF;Papkovsky, DB;Atkins, JF;Baranov, PV;Shatsky, IN;Andreev, DE (2020) 'Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF'. Proceedings of The National Academy of Sciences of The United States of America, 117 :24936-24946 [DOI] [Details]
(2020) 'The use of optical oxygen sensing and respirometry to quantify the effects of antimicrobials on common food spoilage bacteria and food samples'
Elisseeva S.;Kelly C.;Cruz-Romero M.;Zhdanov A.V.;Kerry J.P.;Papkovsky D.B. (2020) 'The use of optical oxygen sensing and respirometry to quantify the effects of antimicrobials on common food spoilage bacteria and food samples'. Sensors and Actuators, B: Chemical, 322 [DOI] [Details]
(2020) 'Characterization of planar phosphorescence based oxygen sensors on a TCSPC-PLIM macro-imager'
Sen R.;Zhdanov A.V.;Hirvonen L.M.;Svihra P.;Andersson-Engels S.;Nomerotski A.;Papkovsky D.B. (2020) 'Characterization of planar phosphorescence based oxygen sensors on a TCSPC-PLIM macro-imager'. Sensors and Actuators, B: Chemical, 321 [DOI] [Details]
(2020) 'Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells'
Kamel, K;O'Brien, CJ;Zhdanov, AV;Papkovsky, DB;Clark, AF;Stamer, D;Irnaten, M (2020) 'Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells'. Investigative Ophthalmology & Visual Science, 61 [DOI] [Details]
(2019) 'Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling'
Torres-Fuentes, C;Golubeva, AV;Zhdanov, AV;Wallace, S;Arboleya, S;Papkovsky, DB;El Aidy, S;Ross, P;Roy, BL;Stanton, C;Dinan, TG;Cryan, JF;Schellekens, H (2019) 'Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling'. The Faseb Journal, 33 :13546-13559 [DOI] [Details]
(2018) 'Nanoparticle‐Based Fluoroionophore for Analysis of Potassium Ion Dynamics in 3D Tissue Models and In Vivo'
Bernhard J. Müller, Alexander V. Zhdanov, Sergey M. Borisov, Tara Foley, Irina A. Okkelman, Vassiliy Tsytsarev, Qinggong Tang, Reha S. Erzurumlu, Yu Chen, Haijiang Zhang, Claudio Toncelli, Ingo Klimant, Dmitri B. Papkovsky, Ruslan I. Dmitriev (2018) 'Nanoparticle‐Based Fluoroionophore for Analysis of Potassium Ion Dynamics in 3D Tissue Models and In Vivo'. Advanced Functional Materials, [DOI] [Details]
(2018) 'Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma'
Irnaten, M;Zhdanov, A;Brennan, D;Crotty, T;Clark, A;Papkovsky, D;O'Brien, C (2018) 'Activation of the NFAT-Calcium Signaling Pathway in Human Lamina Cribrosa Cells in Glaucoma'. Investigative Ophthalmology & Visual Science, 59 :831-842 [DOI] [Details]
(2016) 'Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection'
Pircalabioru, G;Aviello, G;Kubica, M;Zhdanov, A;Paclet, MH;Brennan, L;Hertzberger, R;Papkovsky, D;Bourke, B;Knaus, UG (2016) 'Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection'. Cell Host &Amp; Microbe, 19 :651-663 [DOI] [Details]
(2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'
Golubeva, A. V. and Crampton, S. and Desbonnet, L. and Edge, D. and O'Sullivan, O. and Lomasney, K. W. and Zhdanov, A. V. and Crispie, F. and Moloney, R. D. and Borre, Y. E. and Cotter, P. D. and Hyland, N. P. and O'Halloran, K. D. and Dinan, T. G. and O'Keeffe, G. W. and Cryan, J. F. (2015) 'Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood'. Psychoneuroendocrinology, 60 :58-74 [ Publisher's Version] [DOI] [Details]
(2010) 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells'
Fercher A.;O'Riordan T.;Zhdanov A.;Dmitriev R.;Papkovsky D. (2010) 'Imaging of cellular oxygen and analysis of metabolic responses of mammalian cells'. Methods in molecular biology (Clifton, N.J.), 591 :257-273 [Details]
(2010) 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides. Anal Biochem'
Dmitriev, R. I.,Zhdanov, A. V.,Ponomarev, G. V.,Yashunski, D. V.,Papkovsky, D. B.; (2010) 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides. Anal Biochem'. Anal Biochem, 398 (1):24-33 [ Publisher's Version] [Details]
(2018) 'AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation'
Yordanova, Martina M.; Loughran, Gary; Zhdanov, Alexander V.; Mariotti, Marco; Kiniry, Stephen J.; O’Connor, Patrick B. F.; Andreev, Dmitry E.; Tzani, Ioanna; Saffert, Paul; Michel, Audrey M.; Gladyshev, Vadim N.; Papkovsky, Dmitry B.; Atkins, John F.; Baranov, Pavel V. (2018) 'AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation'. Nature, 553 :356-360 [DOI] [Full Text] [Details]
(2017) 'Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV'
Zhdanov, AV;Andreev, DE;Baranov, PV;Papkovsky, DB (2017) 'Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV'. Free Radical Biology & Medicine, 106 :184-195 [DOI] [Details]
(2017) 'Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells'
Lyons, Amy; Coleman, Michael; Riis, Sarah; Favre, Cedric; O'Flanagan, Ciara H.; Zhdanov, Alexander V.; Papkovsky, Dmitri B.; Hursting, Stephen D.; O'Connor, Rosemary (2017) 'Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells'. Journal of Biological Chemistry, 292 (41):16983-16998 [ Publisher's Version] [DOI] [Full Text] [Details]
(2016) 'Phosphorescence based O 2 sensors–Essential tools for monitoring cell and tissue oxygenation and its impact on metabolism'
Dmitri B. Papkovsky, Alexander V. Zhdanov (2016) 'Phosphorescence based O 2 sensors–Essential tools for monitoring cell and tissue oxygenation and its impact on metabolism'. Free Radical Biology & Medicine, 101 :202-210 [DOI] [Details]
(2016) 'Quantitative analysis of mucosal oxygenation using ex vivo imaging of healthy and inflamed mammalian colon tissue'
Alexander V Zhdanov, Irina A Okkelman, Anna V Golubeva, Barbara Doerr, Niall P Hyland, Silvia Melgar, Fergus Shanahan, John F Cryan, Dmitri B Papkovsky (2016) 'Quantitative analysis of mucosal oxygenation using ex vivo imaging of healthy and inflamed mammalian colon tissue'. Cellular and molecular life sciences : CMLS, :1-11 [DOI] [Details]
(2016) 'Cellular ROS Imaging with Hydro-Cy3 Dye is Strongly Influenced by Mitochondrial Membrane Potential'
Alexander V Zhdanov, Gabriella Aviello, Ulla G Knaus, Dmitri B Papkovsky (2016) 'Cellular ROS Imaging with Hydro-Cy3 Dye is Strongly Influenced by Mitochondrial Membrane Potential'. Biochimica Et Biophysica Acta-General Subjects, [DOI] [Details]
(2015) 'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling'
Zhdanov AV, Waters AHC, Golubeva AV and Papkovsky DB. (2015) 'Differential contribution of key metabolic substrates and cellular oxygen in HIF signalling'. Experimental Cell Research, 330 (1):13-28 [ Publisher's Version] [Details]
(2015) 'Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles'
Dmitriev RI, Borisov SM, Kondrashina AV, Pakan JMP, Anilkumar U, Prehn JHM, Zhdanov, AV, McDermott KW, Klimant I, Papkovsky DB. (2015) 'Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles'. Cellular and Molecular Life Sciences, 72 :367-381 [ Publisher's Version] [DOI] [Details]
(2015) 'Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes'
Andreev DE, O’Connor PBF, Zhdanov AV, Dmitriev RI, Shatsky IN, Papkovsky BD and Baranov PV (2015) 'Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes'. Genome Biology, 16 [ Publisher's Version] [DOI] [Details]
(2015) 'A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression'
Zhdanov AV, Okkelman IA, Collins FWJ, Melgar S, Papkovsky BD (2015) 'A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression'. BBA Biochimica et Biophysica Acta, 1847 (10):1254-1266 [Details]
(2014) 'Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry'
Zhdanov AV;Dmitriev RI;Hynes J;Papkovsky DB; (2014) 'Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry'. Methods In Enzymology, 542 [DOI] [Details]
(2014) 'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling'
Zhdanov AV, Waters AHC, Golubeva AV, Dmitriev RI and Papkovsky DB (2014) 'Availability of the key metabolic substrates dictates the respiratory response of cancer cells to the mitochondrial uncoupling'. BBA Biochimica et Biophysica Acta, 1837 (1):51-62 [Details]
(2014) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'
Fogarty FM, O'Keeffe J, Zhdanov A, Papkovsky D, Ayllon V and O'Connor R (2014) 'HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H+ ATPase'. Oncogene, 33 :4653-4663 [DOI] [Details]
(2014) 'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors'
Golubeva AV, Zhdanov AV, Mallel G, Dinan TG and Cryan JF. (2014) 'The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors'. Physiol Repphysiol Rep, 2 (33) [ Publisher's Version] [Details]
(2014) 'Small molecule phosphorescent probes for O2 imaging in 3D tissue models'
Dmitriev RI, Kondrashina AV, Koren K, Klimant I, Zhdanov AV, Pakan JMP, McDermott KW and Papkovsky DB (2014) 'Small molecule phosphorescent probes for O2 imaging in 3D tissue models'. Biomaterials Science, 2 :853-866 [Details]
(2013) 'Imaging of neurosphere oxygenation with phosphorescent probes'
Dmitriev RI, Zhdanov AV, Nolan YM and Papkovsky DB (2013) 'Imaging of neurosphere oxygenation with phosphorescent probes'. Biomaterials, 34 :9307-9317 [Details]
(2013) 'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells'
Zhdanov AV, Dmitriev RI, Golubeva AV, Gavrilova SA, Papkovsky DB (2013) 'Chronic hypoxia leads to a glycolytic phenotype and suppressed HIF-2 signaling in PC12 cells'. BBA Biochimica et Biophysica Acta, 1830 (6):3553-3569 [ Publisher's Version] [Details]
(2012) 'Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling'
Zhdanov AV, Dmitriev RI, Papkovsky DB (2012) 'Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling'. Bioscience reports, 32 (6):587-595 [DOI] [Details]
(2012) 'A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities'
Kondrashina AV, Dmitriev RI, Borisov SM, Klimant I, O'Brien I, Nolan YM, Zhdanov AV, Papkovsky DB (2012) 'A Phosphorescent Nanoparticle-Based Probe for Sensing and Imaging of (Intra)Cellular Oxygen in Multiple Detection Modalities'. Advanced Functional Materials, 22 (23):4931-4939 [Details]
(2012) 'Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-Sensitive Probes'
Dmitriev RI, Zhdanov AV, Jasionek G and Papkovsky DB (2012) 'Assessment of Cellular Oxygen Gradients with a Panel of Phosphorescent Oxygen-Sensitive Probes'. Analytical Chemistry, 84 (6):2930-2938 [Details]
(2011) 'Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria'
Zhdanov AV, Dmitriev RI, Papkovsky DB (2011) 'Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria'. Cellular and molecular life sciences : CMLS, 68 (5):903-917 [ Publisher's Version] [Details]
(2011) 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform'
Zhdanov AV, Favre C, O'Flaherty L, Adam J, O'Connor R, Pollard PJ, Papkovsky DB (2011) 'Comparative bioenergetic assessment of transformed cells using a cell energy budget platform'. Integrative biology : quantitative biosciences from nano to macro, 3 (11):1135-1142 [DOI] [Details]
(2011) 'Intracellular O2 Sensing Probe Based on Cell-Penetrating Phosphorescent Nanoparticles'
Fercher A, Borisov SM, Zhdanov AV, Klimant I and Papkovsky DB (2011) 'Intracellular O2 Sensing Probe Based on Cell-Penetrating Phosphorescent Nanoparticles'. ACS Nano, 5 (7):5499-5508 [Details]
(2010) 'Bactenecin 7 peptide fragment as a tool for intracellular delivery of a phosphorescent oxygen sensor'
Dmitriev RI, Ropiak HM, Yashunsky DV, Ponomarev GV, Zhdanov AV and Papkovsky DB (2010) 'Bactenecin 7 peptide fragment as a tool for intracellular delivery of a phosphorescent oxygen sensor'. Febs Journal, 277 (22):4651-4661 [Details]
(2010) 'Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism'
O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung Y-L, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ and Pollard PJ (2010) 'Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism'. Human Molecular Genetics, 19 (19):3844-3851 [Details]
(2010) 'Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique'
Zhdanov AV, Ogurtsov VI, Taylor CT, Papkovsky DB. (2010) 'Monitoring of cell oxygenation and responses to metabolic stimulation by intracellular oxygen sensing technique'. Integrative Biology, 2 (9):443-451 [Details]
(2010) 'Mitochondrial Toxicity of Microcystin-LR on Cultured Cells: Application to the Analysis of Contaminated Water Samples'
Jasionek G, Zhdanov A, Davenport J, Bláha L and Papkovsky DB (2010) 'Mitochondrial Toxicity of Microcystin-LR on Cultured Cells: Application to the Analysis of Contaminated Water Samples'. Environmental Science & Technology, 44 (7):2535-2541 [DOI] [Details]
(2010) 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells'
Favre C, Zhdanov A, Leahy M, Papkovsky D, O'Connor R; (2010) 'Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells'. Oncogene, 29 (27):3964-3976 [DOI] [Details]
(2010) 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides'
Dmitriev RI, Zhdanov AV, Ponomarev GV, Yashunski DV and Papkovsky, DB (2010) 'Intracellular oxygen-sensitive phosphorescent probes based on cell-penetrating peptides'. Analytical Biochemistry, 398 (1):24-33 [ Publisher's Version] [Details]
(2010) 'Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange'
Zhdanov AV, Ward MW, Taylor CT, Souslova EA, Chudakov DM, Prehn JHM and Papkovsky DB (2010) 'Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange'. BBA Biochimica et Biophysica Acta, 1797 (9):1627-1637 [ Publisher's Version] [Details]
(2009) 'In vitro analysis of cell metabolism using a long-decay pH-sensitive lanthanide probe and extracellular acidification assay'
Hynes J, O’Riordan TC, Zhdanov AV, Uray G, Will Y and Papkovsky DB (2009) 'In vitro analysis of cell metabolism using a long-decay pH-sensitive lanthanide probe and extracellular acidification assay'. Analytical Biochemistry, 390 (1):21-28 [ Publisher's Version] [Details]
(2009) 'PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'
O'Hagan KA, Cocchiglia S, Zhdanov AV, Tambuwala MM, Cummins EP, Monfared M, Agbor TA, Garvey JF, Papkovsky DB, Taylor CT, Allan BB (2009) 'PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'. Proceedings of the National Academy of Sciences, 106 (7):2188-2193 [Details]
(2008) 'Dynamics of intracellular oxygen in PC12 cells upon stimulation of neurotransmission'
Zhdanov AV, Ward MW, Prehn JHM and Papkovsky db (2008) 'Dynamics of intracellular oxygen in PC12 cells upon stimulation of neurotransmission'. Journal of Biological Chemistry, 283 (9):5650-5661 [Details]
(2007) 'Analysis of Intracellular Oxygen and Metabolic Responses of Mammalian Cells by Time-Resolved Fluorometry'
O'Riordan TC, Zhdanov AV, Ponomarev GV, Papkovsky DB (2007) 'Analysis of Intracellular Oxygen and Metabolic Responses of Mammalian Cells by Time-Resolved Fluorometry'. Analytical Chemistry, 79 (24):9414-9419 [ Publisher's Version] [Details]
(2007) 'Rab11-FIP3 Is Critical for the Structural Integrity of the Endosomal Recycling Compartment'
Horgan CP, Oleksy A, Zhdanov AV, Lall PY, White IJ, Khan AR, Futter CE, McCaffrey JG and McCaffrey MW (2007) 'Rab11-FIP3 Is Critical for the Structural Integrity of the Endosomal Recycling Compartment'. Traffic (Copenhagen, Denmark), 8 (4):414-430 [Details]
(2004) 'Neuronal Functions of the Novel Serine/Threonine Kinase Ndr2'
Stork O, Zhdanov A, Kudersky A, Yoshikawa T, Obata K, Pape H-C (2004) 'Neuronal Functions of the Novel Serine/Threonine Kinase Ndr2'. Journal of Biological Chemistry, 279 (44):45773-45781 [Details]

Conference Publications

  Year Publication
(2017) ADVANCED ENVIRONMENTAL, CHEMICAL, AND BIOLOGICAL SENSING TECHNOLOGIES XIV
Papkovsky, DB;Zhdanov, AV (2017) Phosphorescence based oxygen sensors and probes for biomedical research ADVANCED ENVIRONMENTAL, CHEMICAL, AND BIOLOGICAL SENSING TECHNOLOGIES XIV [DOI] [Details]
(2011) ACS Nano
Fercher A.;Borisov S.;Zhdanov A.;Klimant I.;Papkovsky D. (2011) Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles ACS Nano , pp.5499-5508 [DOI] [Details]

Abstract

  Year Publication
(2019) Reduced Oxidative Phosphorylation and Increased Glycolysis (The Warburg Effect) in Glaucoma Lamina Cribrosa Cells.
Kamel, K;Irnaten, M;Zhdanov, A;Papkovsky, D;O'Brien, CJ (2019) Reduced Oxidative Phosphorylation and Increased Glycolysis (The Warburg Effect) in Glaucoma Lamina Cribrosa Cells. ROCKVILLE: Abstract [Details]
(2015) LOXL2 Expression in HCT116 Cells under Normoxia is Regulated by ROS and HIF Signaling.
Okkelman, I;Dmitriev, R;Zhdanov, A;Papkovsky, D (2015) LOXL2 Expression in HCT116 Cells under Normoxia is Regulated by ROS and HIF Signaling. BETHESDA: Abstract [Details]
(2013) Phosphorescent nanoparticle based probes for imaging and measurement of cellular oxygen.
Kondrashina, A;Dmitriev, R;Borisov, S;Klimant, I;Zhdanov, A;Papkovsky, D (2013) Phosphorescent nanoparticle based probes for imaging and measurement of cellular oxygen. BETHESDA: Abstract [Details]
(2012) Availability of key metabolic substrates determines metabolic responses, local oxygenation and HIF-2a stabilization in pheochromocytoma PC12 cells.
Zhdanov, A;Waters, A;Golubeva, A;Dmitriev, R;Papkovsky, D (2012) Availability of key metabolic substrates determines metabolic responses, local oxygenation and HIF-2a stabilization in pheochromocytoma PC12 cells. AMSTERDAM: Abstract [DOI] [Details]

Patents

  Patent Number Title Granted
2291651 Method of Toxicological Assessment 09-MAR-11
2012052068 Method and probe for monitoring oxygen status in live mammalian cells 27-APR-12

Conference Contributions

  Year Publication
(2014) 18th European Bioenergetics Conference,
A Zhdanov, F Collins, I Okkelman, D Papkovsky (2014) HIF-independent inhibition of mitochondrial function by DMOG: Immediate–early effects and long-term consequences. [Poster Presentation], 18th European Bioenergetics Conference, Lisbon, Portugal , 12-JUL-14 - 17-JUL-14. [Details]
(2013) Experimental Biology conference,
Kondrashina A, Dmitriev R, Borisov S, Klimant I, Zhdanov A, Papkovsky D (2013) FASEB JOURNAL. [Poster Presentation], Experimental Biology conference, Boston, USA . [Details]

Education

  Year Institution Qualification Subject
1997 Moscow State University PhD Diagnostics of C. trachomatis by PCR and evaluation of the parameters of the immune and interferon status in urogenital chlamydiosis
1992 Moscow State University M.Sc. Development of the procedure of diagnostics of herpes simplex virus and chlamydiosis in clinical samples using DNA-hybridization and PCR

Languages

  Language Reading Writing Speaking
English Fluent Fluent Fluent
Russian Fluent Fluent Fluent
German Basic Basic Basic

Internal Collaborators

  Name Institute Country
Dr. Pavel Baranov University College Cork IRELAND