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4. Roisin Kelly

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Biography

Dr. Roisin Kelly-Laubscher is a Lecturer in Pharmacology & Therapeutics at University College Cork, Ireland. Her Ph.D. research focused on arterial hemodynamics, the arterial endothelium, and the endothelial glycocalyx. In 2006, she started a postdoctoral position at the Hatter Institute for Cardiovascular Research at the University of Cape Town (UCT) where she worked under the guidance of Prof. Lionel H Opie and Prof. Sandrine Lecour. From August 2009- Feb 2018, she was appointed to an academic post at UCT. While there her research focused on the role of ethanolamine and the endothelial glycocalyx in cardioprotection. More recently, in conjunction with her colleague Dr. Orla Barry, who specializes in Cancer Pharmacology, she has begun to focus on cardioprotection in drug-induced cardiotoxicity.‍

Research Interests

• Cardioprotection
• Drug-Induced cardiotoxicity
• Endothelial glycocalyx

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2020)	'Ethanolamine: A Potential Promoiety with Additional Effects in the Brain' Gwanyanya A;Godsmark CN;Kelly-Laubscher R; (2020) 'Ethanolamine: A Potential Promoiety with Additional Effects in the Brain'. CNS & neurological disorders drug targets, [DOI] [Details]
	(2020)	'The effect of sphingosine-1-phosphate on the endothelial glycocalyx during ischemia-reperfusion injury in the isolated rat heart' Araibi, H;van der Merwe, E;Gwanyanya, A;Kelly-Laubscher, R (2020) 'The effect of sphingosine-1-phosphate on the endothelial glycocalyx during ischemia-reperfusion injury in the isolated rat heart'. Microcirculation, [DOI] [Details]
	(2017)	'Beneficial Effects of Magnesium Treatment on Heart Rate Variability and Cardiac Ventricular Function in Diabetic Rats' Amoni M and Kelly-Laubscher R and Blackhurst D and Gwanyanya A (2017) 'Beneficial Effects of Magnesium Treatment on Heart Rate Variability and Cardiac Ventricular Function in Diabetic Rats'. Journal Of Cardiovascular Pharmacology And Therapeutics, [DOI] [Details]
	(2017)	'Cardioprotective and Anti-arrhythmic Effects of Magnesium Pretreatment Against Ischaemia/Reperfusion Injury in Isoprenaline-Induced Hypertrophic Rat Heart' Amoni M and Kelly-Laubscher R and Petersen M and Gwanyanya A (2017) 'Cardioprotective and Anti-arrhythmic Effects of Magnesium Pretreatment Against Ischaemia/Reperfusion Injury in Isoprenaline-Induced Hypertrophic Rat Heart'. Cardiovascular Toxicology, [DOI] [Details]
	(2017)	'The potential of student narratives to enhance quality in higher education' Claire Hamshire and Rachel Forsyth and Amani Bell and Matthew Benton and Roisin Kelly-Laubscher and Moragh Paxton and `Ema Wolfgramm-Foliaki (2017) 'The potential of student narratives to enhance quality in higher education'. Quality in Higher Education, :1-15   [DOI] [Details]
	(2017)	'Supporting the teaching of the visual literacies in the earth and life sciences in higher education' Moragh Paxton and Vera Frith and Roisin Kelly-Laubscher and Natashia Muna and Mathilde van der Merwe (2017) 'Supporting the teaching of the visual literacies in the earth and life sciences in higher education'. Higher Education Research and Development, :1-16   [DOI] [Details]
	(2017)	'Using the research article as a model for teaching laboratory report writing provides opportunities for development of genre awareness and adoption of new literacy practices' Roisin F. Kelly-Laubscher and Natashia Muna and Mathilde van der Merwe (2017) 'Using the research article as a model for teaching laboratory report writing provides opportunities for development of genre awareness and adoption of new literacy practices'. English for Specific Purposes, 48 :1-16   [DOI] [Details]
	(2016)	'Differences in Curriculum Structure between High School and University Biology: The Implications for Epistemological Access' Roisin Kelly-Laubscher (2016) 'Differences in Curriculum Structure between High School and University Biology: The Implications for Epistemological Access'. Journal of Biological Education,   [DOI] [Details]
	(2016)	'First-year medical students\textquotesingle naïve beliefs about respiratory physiology' Elmi Badenhorst and Silvia Mamede and Amaal Abrahams and Kishor Bugarith and Jacqui Friedling and Geney Gunston and Roisin Kelly-Laubscher and Henk G. Schmidt (2016) 'First-year medical students\textquotesingle naïve beliefs about respiratory physiology'. Advances in Physiology Education, 40 (3):342-348   [DOI] [Details]
	(2015)	'Lack of cardioprotection by single-dose magnesium prophylaxis on isoprenaline-induced myocardial infarction in adult Wistar rats: cardiovascular topics' Garson, Christie and Kelly-Laubscher, Roisin and Blackhurst, Dee and Gwanyanya, Asfree (2015) 'Lack of cardioprotection by single-dose magnesium prophylaxis on isoprenaline-induced myocardial infarction in adult Wistar rats: cardiovascular topics'. Cardiovascular Journal of Africa, 26 (6):242-249 [Details]
	(2015)	'Cellular targets of inhalational anaesthetic-and opioid receptor agonist-induced cardioprotection' Gwanyanya, Asfree and Kelly-Laubscher, Roisin (2015) 'Cellular targets of inhalational anaesthetic-and opioid receptor agonist-induced cardioprotection'. Journal of African Association of Physiological Sciences, 3 (1):1-8 [Details]
	(2014)	'Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3: cardiovascular topic' Kelly-Laubscher, Roisin F and King, Jonathan C and Hacking, Damian and Somers, Sarin and Hastie, Samantha and Stewart, Tessa and Imamdin, Aqeela and Maarman, Gerald and Pedretti, Sarah and Lecour, Sandrine (2014) 'Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3: cardiovascular topic'. Cardiovascular Journal of Africa, 25 (3):118-123 [Details]
	(2013)	'Detrimental effects of acute hyperglycaemia on the rat heart' Mapanga, Rudo F and Joseph, Danzil and Symington, Burger and Garson, K-L and Kimar, Charlene and Kelly-Laubscher, Roisin and Essop, M Faadiel (2013) 'Detrimental effects of acute hyperglycaemia on the rat heart'. Acta Physiologica, 210 (3):546-564 [Details]
	(2012)	'Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction' Mapanga, Rudo F and Rajamani, Uthra and Dlamini, Nonkululeko and Zungu-Edmondson, Makhosazane and Kelly-Laubscher, Roisin and Shafiullah, Mohammed and Wahab, Athiq and Hasan, Mohamed Y and Fahim, Mohamed A and Rondeau, Philippe and others (2012) 'Oleanolic acid: a novel cardioprotective agent that blunts hyperglycemia-induced contractile dysfunction'. Plos One, 7 (10) [Details]
	(2012)	'The effects of acute ethanolamine administration on isoprenaline-induced myocardial infarction in adult Wistar rats' Garson, Christie and Gwanyanya, Asfree and Bugarith, Kishor and Kelly-Laubscher, Roisin (2012) 'The effects of acute ethanolamine administration on isoprenaline-induced myocardial infarction in adult Wistar rats'. South African Heart Journal, 9 (3) [Details]
	(2011)	'The effect of arterial wall shear stress on the incremental elasticity of a conduit artery' Roisin Kelly and Henry Michael Snow (2011) 'The effect of arterial wall shear stress on the incremental elasticity of a conduit artery'. Acta Physiologica,   [Details]
	(2010)	'Ethanolamine is a novel STAT-3 dependent cardioprotective agent' Kelly, Roisin F and Lamont, Kim T and Somers, Sarin and Hacking, Damian and Lacerda, Lydia and Thomas, Paul and Opie, Lionel H and Lecour, Sandrine (2010) 'Ethanolamine is a novel STAT-3 dependent cardioprotective agent'. Basic Research in Cardiology, 105 (6):763-770 [Details]
	(2008)	'Dilatation In The Femoral Vascular Bed Does Not Cause Retrograde Relaxation of The Iliac Artery In The Anaesthetized Pig' Markos, F, Ruane-O'Hora, T, Snow, HM, Kelly, R, Wainwright, C, Skene, K, Drake-Holland, AJ, Noble, MIM; (2008) 'Dilatation In The Femoral Vascular Bed Does Not Cause Retrograde Relaxation of The Iliac Artery In The Anaesthetized Pig'. Acta Physiologica, 194 (3):207-213 [DOI] [Details]
	(2007)	'Characteristics of the response of the iliac artery to wall shear stress in the anaesthetized pig' Kelly, RF and Snow, HM (2007) 'Characteristics of the response of the iliac artery to wall shear stress in the anaesthetized pig'. The Journal of Physiology, 582 (2):731-743 [Details]
	(2006)	'Differential inhibition by hyperglycaemia of shear stress- but not acetylcholine-mediated dilatation in the iliac artery of the anaesthetized pig' Kelly, R,Ruane-O'Hora, T,Noble, MIM,Drake-Holland, AJ,Snow, HM; (2006) 'Differential inhibition by hyperglycaemia of shear stress- but not acetylcholine-mediated dilatation in the iliac artery of the anaesthetized pig'. Journal of Physiology-London, 573 :133-145 [DOI] [Details]

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Conference Publications

	Year	Publication
	(2008)	International Society for Heart Research, Athens, 2008 Kelly, Roisin and King, Jonathan and Lecour, Sandrine (2008) Sphingosine-1-phosphate induced cardioprotection is mediated by STAT-3 International Society for Heart Research, Athens, 2008 , pp.740-741 [Details]
	(2007)	Royal Academy of Medicine in Ireland, Summer Meeting, Cork Ruane-O¿Hora T, Noble MIM, Kelly R, Drake-Holland AJ & Snow HM. ; (2007) Effect of Hyperglycaemia On The Endothelial Glycocalyx Royal Academy of Medicine in Ireland, Summer Meeting, Cork [Details]
	(2004)	Physiological Society Annual Meeting Kelly, R and Peim, A and Walz, A and others (2004) Reversal of digoxin cardiac toxicity by an Anticalin (Digical II) in the anaesthetized guinea pig Physiological Society Annual Meeting Cork, [Details]

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Published Reports

	Year	Publication
	(2012)	2nd South Africa–United Kingdom cardiovascular workshop. Kelly-Laubscher R and Burger G and Davies N and Engelbrecht A and Sliwa K and Lecour S and Strijdom H and Hausenloy D (2012) 2nd South Africa–United Kingdom cardiovascular workshop. Cardiovascular Journal of Africa, South Africa. [Details]

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Professional Activities

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Honours and Awards

	Year	Title	Awarding Body
	2015	Andries Brink-Kaye Award for the most outstanding scientific publication in the Cardiovascular Journal of Africa for 2014	Cardiovascular Journal of Africa
	2012	National Research Foundation Y Rating	National Research Foundation of South Africa

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Professional Associations

	Association	Function	From / To
	Physiological Society	Member	22-JAN-20 /
	European Society for Cardiology	Member	07-JUL-20 /

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Employment

	Employer	Position	From / To
	University of Cape Town	Senior Lecturer	01-JAN-16 / 28-DEC-18
	University of Cape Town	Lecturer	01-JUN-09 / 31-DEC-16
	Hatter Institute for Cardiovascular Research	Postdoctoral Fellow	01-JUN-06 / 30-JUN-09

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Education

	Year	Institution	Qualification	Subject
	2017	University of Cape Town	MEd	Higher Education Studies
	2006	University College Cork	PhD	Cardiovascular Physiology
	2003	University College Cork	BSc	Physiology

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Journal Activities

	Journal	Role	To / From
	Journal Of Cardiovascular Pharmacology	Referee	22-JUL-13 -
	Cardiovascular Journal Of Africa	Referee	19-OCT-15 -
	Pharmacological Research	Referee	23-OCT-19 -
	Fundamental & Clinical Pharmacology	Referee	11-MAR-20 -
	Molecular And Cellular Biochemistry	Referee	01-JAN-21 -

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Teaching Activities

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Recent Postgraduates

	Graduation Year	Student Name	Institution	Degree Type	Thesis Title
	2020	Marie O Dea	University College Cork		In-vitro short-term cytotoxicity induced by epigenetic drugs

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Research Information

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Internal Collaborators

	Name	Institute	Country
	Dr. Orla Barry	University College Cork	IRELAND

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External Collaborators

	Name	Organisation / Institute	Country
	Prof Sandrine Lecour	Hatter Institute for Cardiovascular Research	SOUTH AFRICA