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4. Susan Joyce

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Biography

Susan Joyce (BSc, PhD, CM, PGCE) is Faculty at UCC and a PI in the UCC Food Institute and an investigator in APC Microbiome Ireland Health. Her research interests revolve around metabolism and altered human, host and microbial metabolic pathways, with food,  that can influence health and disease. She leads a metabolomics focused research group in diverse areas of host response through small molecule analysis (MS applications), cellular systems, gene expression and signalling readout, clinical interphase, microbial associations in terms of strain isolation, functional and phenotypic characterization including their metabolites and genetics,  Areas currently  under investigation include (1) the use of a metabolomic approach to identify novel biomarkers of microbial  dietary ingredients in fermentation  and (2) the use of metabolomic signatures in deciphering health and ageing (3) specific microbial enzyme inhibition and applications to alter metabolomic signatures towards healthy weight gain.  Susan is a recipient of DAFM funding. She is a partner in the FP7 project SOPHIA, with a focus on obesity. She represents her School and APC Microbiome Ireland in the Joint Programming Initiative (JPI) CABALA for health, where she is a partner. She has published over 90  publications including publications in leading journals including Ange Wat chimie.  PNAS, GUT, J Hepatol and Nature Comms. She regularly serves as a reviewer for international grant awards and for international journals and she is serving as an associate editor Frontiers in Nutrition and editorial Board of Liver research. She is actively involved in undergraduate teaching and delivers a range of lectures in genetics, and in advanced metabolism at all BSc levels and to Medical students. She is secretary of the Irish Mass Spectrometry Society (IMSS).  Her full publication list is available at: http://orcid.org/0000-0003-4771-3123 and at https://scholar.google.com/citations?hl=en&user=6KpVtU0AAAAJ

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Research Interests

I am interested in the genetic and biochemical basis of host-microbe interactions, their regulation and outcomes. RESEARCH GROUP OVERVIEW: Gut  (and in certain disease states systemic health) is shaped by diet, environment and gut microbial changes as well as by host genetics.  The influence of these combined factors contributes to processes including gut development and homeostasis, immune function and local and systemic signalling in defining health outcomes.   My group dissects how these different and combined factors can impact health, disease and longevity. The group has focused on microbial host-metabolite and dietary modification that impact the host  (including drug uptake, adiposity, circadian rhythm, immune functions) with a particular emphasis on signalling processes to identity key areas for therapeutic approaches.  We apply targeted and untargeted metabolomic approaches, animal models, cell systems and bacterial molecular and cellular biology to address our questions.

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	ERA HDHL-ERA-Net on Biomarkers for Nutrition and Health.	Science Foundation of Ireland	01-JAN-17	31-DEC-20	€249,600.00
		HEACOVID19	01-APR-21	31-JUL-21	€5,933.00
		HEACOVID19	01-APR-21	31-JUL-21	€16,875.00
	SOPHIA “Stratification of Obese Phenotypes to Optimize Future Obesity Therapy”	Horizon 2020	01-JUN-20	31-MAY-25	€20,000.00
	Redressing the Impact of Industrialization on Gut Microbiome Composition and Function (Microbe Restore)	Science Foundation of Ireland	01-NOV-20	31-OCT-25	€205,000.00
		HEACOVID19	01-APR-21	31-AUG-21	€11,298.00
		HEACOVID19	01-DEC-20	30-APR-21	€17,117.00
	APC4 12/RC/2273_P2 Spoke 4 Microbe Dialogue: Aim 4.2b	Science Foundation of Ireland	01-JUN-19	31-MAY-25	€515,278.00
	APC4_12/RC/2273_P2 - TP Pepsico - Susan Joyce	SFI Industry	01-JUL-19	31-AUG-21	€155,865.00
	SFI 12-RC-2273_P2 IND Pepsico TP"Fermented Oat Dairy Project" Dr Susan Joyce [X]	SFI Industry	01-JUN-19	31-MAR-20	€61,113.00
	Fermented Oat Dairy Product	SFI Industry	01-NOV-18	31-MAY-19	€11,037.00
	An Analysis of the Role of Eraly Gut Colonizers, E-coli and Bacteroides, In Bile Acid Metabolism.	Irish Research Council	01-SEP-19	31-AUG-23	€105,333.00
	Exploring clues from the changing phenotype of Crohns Disease	Health Research Board	01-OCT-13	30-SEP-16
	Science Foundation Ireland; Infrastructure Category D, Opportunistic Funds; R17475 is the main project	Science Foundation of Ireland	01-JAN-17	30-JUN-19	€30,828.00
	Improved animal husbandry through inhibition of microbial bile salt hydrolase (NAGpro)	Department of Agriculture Fisheries & Forestry (DAFF)	01-NOV-18	31-OCT-21	€301,874.00
	The effect of PepsiCo prebiotic in cases of mild to moderate hypercholesterolemia	Industry	01-SEP-18	31-MAY-19	€95,890.00
	Lily Research Scholarship	Irish Funded Research	01-OCT-17	30-SEP-21	€111,080.00
	Unravelling the metabolic etiology of inflammatory bowel disease (IBD) via lipidome, metabolome and microbiome multivariate analysis	Miscellaneous	05-NOV-18	31-OCT-21	€72,800.00
	APC Microbiome Institute Spoke 4A Host Microbe Dialogue	Science Foundation Ireland	01-JUN-13	31-MAY-19
	Janssen contribution to a targeted project part funded by SFI under 12/RC/2273 (APC3 Research Centre)	SFI Industry	15-FEB-16	01-JUL-17	€144,461.00

Contract Researchers

	Researcher Name	Project	Role	Funding Body
	Darragh Mattimoe	Industry	Academic Sponsor	Industry Sponsor
	Dr Amed Kabir	Industry	Academic Sponsor	Industry Sponsor
	Dr Karim Hayoun	DAFM- NAG Pro	Academic Sponsor	Department of Agriculture, Fisheries & Food (DAFF)
	Dr Anirudh Jaisimha	Cabala SFI-JPI EU	Postdoctoral Researcher	European Commission
	Dr Eileen Ryan	IBD-ome APEX Fellow	Postdoctoral Researcher	European Commission

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Publications

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Abstract

	Year	Publication
	(2017)	Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. Golubeva, A;Joyce, S;Moloney, G;Burokas, A;Sherwin, A;Arboleya, S;Murphy, K;Hyland, N;Stanton, C;Clarke, G;Gahan, C;Dinan, T;Cryan, J (2017) Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. HOBOKEN: Abstract [Details]
	(2015)	Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model. Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fouhy, F;Scurr, M;Cotter, PD;Gahan, CG;Bines, JE (2015) Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model. HOBOKEN: Abstract [Details]
	(2015)	Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease. Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fuller, PJ;Bines, JE (2015) Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease. HOBOKEN: Abstract [Details]

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Encyclopedia Entries

	Year	Publication
		Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression. Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression. . Encyclopedia Entries. [DOI] [Details]

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Peer Reviewed Journals

	Year	Publication
	(2021)	'Dietary Fibre Modulates the Gut Microbiota' Cronin P;Joyce SA;O'Toole PW;O'Connor EM; (2021) 'Dietary Fibre Modulates the Gut Microbiota'. Nutrients, 13 (5) [DOI] [Details]
	(2021)	'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli' Duysburgh C;Van den Abbeele P;Kamil A;Fleige L;De Chavez PJ;Chu Y;Barton W;O'Sullivan O;Cotter PD;Quilter K;Joyce SA;Murphy M;DunnGalvin G;Dinan TG;Marzorati M; (2021) 'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli'. Pathogens (Basel, Switzerland), 10 (2) [DOI] [Details]
	(2020)	'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer' Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen (2020) 'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer'. Results And Problems In Cell Differentiation, 69 [DOI] [Full Text] [Details]
	(2020)	'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions' Enright E.F.;Joyce S.A.;Gahan C.G.M.;Taylor L.S. (2020) 'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions'. European Journal Of Pharmaceutics And Biopharmaceutics, 153 :68-83 [DOI] [Details]
	(2020)	'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities' Prete, Roberta; Long, Sarah L.; Joyce, Susan A.; Corsetti, Aldo (2020) 'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities'. Fems Microbiology Letters, [DOI] [Full Text] [Details]
	(2020)	'Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer' Keane J.M.;Joyce S.A.;Gahan C.G.M.;Hyland N.P.;Houston A. (2020) 'Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer'. Results And Problems In Cell Differentiation, 69 :581-603 [DOI] [Full Text] [Details]
	(2020)	'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease' Ryan F.J.;Ahern A.M.;Fitzgerald R.S.;Laserna-Mendieta E.J.;Power E.M.;Clooney A.G.;O’Donoghue K.W.;McMurdie P.J.;Iwai S.;Crits-Christoph A.;Sheehan D.;Moran C.;Flemer B.;Zomer A.L.;Fanning A.;O’Callaghan J.;Walton J.;Temko A.;Stack W.;Jackson L.;Joyce S.A.;Melgar S.;DeSantis T.Z.;Bell J.T.;Shanahan F.;Claesson M.J. (2020) 'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease'. Nature Communications, 11 (1) [DOI] [Full Text] [Details]
	(2020)	'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system' Geng W.;Long S.L.;Chang Y.J.;Saxton A.M.;Joyce S.A.;Lin J. (2020) 'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
	(2020)	'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin' Prete R.;Long S.;Gallardo A.;Gahan C.;Corsetti A.;Joyce S. (2020) 'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
	(2019)	'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection' Mullish B.;McDonald J.;Pechlivanis A.;Allegretti J.;Kao D.;Barker G.;Kapila D.;Petrof E.;Joyce S.;Gahan C.;Glegola-Madejska I.;Williams H.;Holmes E.;Clarke T.;Thursz M.;Marchesi J. (2019) 'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection'. Gut, [DOI] [Full Text] [Details]
	(2019)	'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome' O’Donovan S.;Crowley E.;Brown J.;O’Sullivan O.;O’Leary O.;Timmons S.;Nolan Y.;Clarke D.;Hyland N.;Joyce S.;Sullivan A.;O'Neill C. (2019) 'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome'. Neurogastroenterology and Motility, [DOI] [Details]
	(2019)	'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome' Susan A. Joyce, Alison Kamil, Lisa Fleige and Cormac G. M. Gahan (2019) 'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome'. Frontiers in Nutrition, 6 [DOI] [Details]
	(2019)	'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe' Ryan, PM;Stolte, EH;London, LEE;Wells, JM;Long, SL;Joyce, SA;Gahan, CGM;Fitzgerald, GF;Ross, RP;Caplice, NM;Stanton, C (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC Microbiology, 19 [DOI] [Details]
	(2018)	'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein' Enright EF;Govindarajan K;Darrer R;MacSharry J;Joyce SA;Gahan CGM; (2018) 'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'. Molecular Pharmaceutics, [DOI] [Details]
	(2018)	'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis' Laserna-Mendieta, EJ;Clooney, AG;Carretero-Gomez, JF;Moran, C;Sheehan, D;Nolan, JA;Hill, C;Gahan, CGM;Joyce, SA;Shanahan, F;Claesson, MJ (2018) 'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'. Journal Of Crohns & Colitis, 12 :204-216 [DOI] [Details]
	(2018)	'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection' Brown, JRM;Flemer, B;Joyce, SA;Zulquernain, A;Sheehan, D;Shanahan, F;O'Toole, PW (2018) 'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'. BMC Gastroenterology, 18 [DOI] [Details]
	(2018)	'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism' Enright, E.F. and Griffin, B.T. and Gahan, C.G.M. and Joyce, S.A. (2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'. Pharmacological Research, 133 :170-186   [DOI] [Details]
	(2017)	'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism' Golubeva AV;Joyce SA;Moloney G;Burokas A;Sherwin E;Arboleya S;Flynn I;Khochanskiy D;Moya-Pérez A;Peterson V;Rea K;Murphy K;Makarova O;Buravkov S;Hyland NP;Stanton C;Clarke G;Gahan CGM;Dinan TG;Cryan JF; (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. Ebiomedicine, 24 [DOI] [Details]
	(2017)	'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens' Langer, Angela; Moldovan, Adriana; Harmath, Christian; Joyce, Susan A.; Clarke, David J.; Heermann, Ralf (2017) 'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'. Plos One, 12 (4):1-23 [DOI] [Full Text] [Details]
	(2017)	'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota' Joyce SA;Gahan CG; (2017) 'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'. Journal of Digestive Diseases, 35 (3) [DOI] [Details]
	(2017)	'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism' Golubeva, Anna V.,Joyce, Susan A.,Moloney, Gerard,Burokas, Aurelijus,Sherwin, Eoin,Arboleya, Silvia,Flynn, Ian,Khochanskiy, Dmitry,Moya-Pérez, Angela,Peterson, Veronica,Rea, Kieran,Murphy, Kiera,Makarova, Olga,Buravkov, Sergey,Hyland, Niall P.,Stanton, Catherine,Clarke, Gerard,Gahan, Cormac G. M.,Dinan, Timothy G.,Cryan, John F. (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. EBioMedicine, 24 :166-178   [DOI] [Full Text] [Details]
	(2017)	'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome' Pereira-Fantini, Prue M.; Lapthorne, Susan; Gahan, Cormac G. M.; Joyce, Susan A.; Charles, Jenny; Fuller, Peter J.; Bines, Julie E. (2017) 'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'. Cellular And Molecular Gastroenterology And Hepatology, 4 (1):65-74 [DOI] [Full Text] [Details]
	(2017)	'Interactions between gut bacteria and bile in health and disease' Long SL;Gahan CGM;Joyce SA; (2017) 'Interactions between gut bacteria and bile in health and disease'. Molecular aspects of medicine, 56 [DOI] [Details]
	(2017)	'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression' Nilaweera, KN;Cabrera-Rubio, R;Speakman, JR;O'Connor, PM;McAuliffe, A;Guinane, CM;Lawton, EM;Crispie, F;Aguilera, M;Stanley, M;Boscaini, S;Joyce, S;Melgar, S;Cryan, JF;Cotter, PD (2017) 'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'. American Journal of Physiology (Endocrinology and Metabolism), 313 :1-11 [DOI] [Details]
	(2016)	'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms' Dowd GC;Bahey-El-Din M;Casey PG;Joyce SA;Hill C;Gahan CG; (2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'. Human Vaccines & Immunotherapeutics, [DOI] [Details]
	(2016)	'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome' Enright EF;Gahan CG;Joyce SA;Griffin BT; (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. The Yale journal of biology and medicine, 89 (3) [Details]
	(2016)	'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health' Joyce SA, Gahan CG. (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Food Science and Technology International, 7 (7):313-333 [DOI] [Details]
	(2016)	'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health' Joyce SA;Gahan CG; (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Annual Review Of Food Science And Technology, Vol 1, 7 [DOI] [Details]
	(2016)	'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk' Govindarajan, Kalaimathi; MacSharry, John; Casey, Patrick G.; Shanahan, Fergus; Joyce, Susan A.; Gahan, Cormac G. M. (2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'. Plos One, 11 (1212):e0167319-1-e0167319-13 [DOI] [Full Text] [Details]
	(2016)	'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome' Pereira-Fantini PM, Bines JE, Lapthorne S, Fouhy F, Scurr M, Cotter PD, Gahan CG, Joyce SA. (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Italian Journal of Gastroenterology and Hepatology, [DOI] [Details]
	(2016)	'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk' Govindarajan, Kalaimathi,MacSharry, John,Casey, Patrick G.,Shanahan, Fergus,Joyce, Susan A.,Gahan, Cormac G. M. (2016) 'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'. PLoS ONE, 11 (12)   [DOI] [Full Text] [Details]
	(2016)	'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach' Nolan JA, Kinsella M, Hill C, Joyce SA, Gahan CG. (2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'. Current Microbiology, [DOI] [Details]
	(2016)	'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome' Pereira-Fantini PM;Bines JE;Lapthorne S;Fouhy F;Scurr M;Cotter PD;Gahan CG;Joyce SA; (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Journal of gastroenterology and hepatology, [DOI] [Details]
	(2016)	'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome' Enright, E.F., ,Gahan, C.G.M.,Joyce, S.A.,Griffin, B.T. (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. Yale Journal Of Biology And Medicine, 89 :375-382 [Full Text] [Details]
	(2016)	'Disease-associated changes in bile acid profiles and links to altered gut microbiota' S.A Joyce and C.G. Gahan (2016) 'Disease-associated changes in bile acid profiles and links to altered gut microbiota'. Digestive Diseases, [DOI] [Details]
	(2014)	'The gut microbiota and the metabolic health of the host' Joyce SA, Gahan CG (2014) 'The gut microbiota and the metabolic health of the host'. Current opinion in gastroenterology, 30 (2):120-127 [DOI] [Details]
	(2014)	'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition' Renier, S;Chagnot, C;Deschamps, J;Caccia, N;Szlavik, J;Joyce, SA;Popowska, M;Hill, C;Knochel, S;Briandet, R;Hebraud, M;Desvaux, M (2014) 'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'. Environmental Microbiology, 16 :1176-1192 [DOI] [Details]
	(2014)	'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease' Pereira-Fantini, PM,Lapthorne, S,Joyce, SA,Dellios, NL,Wilson, G,Fouhy, F,Thomas, SL,Scurr, M,Hill, C,Gahan, CGM,Cotter, PD,Fuller, PJ,Hardikar, W,Bines, JE (2014) 'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of hepatology, 61 :1115-1125 [DOI] [Details]
	(2014)	'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut' Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CG (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 (20):7421-7426 [DOI] [Details]
	(2014)	'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk' Susan A. Joyce, Fergus Shanahan, Colin Hill, Cormac G.M. (2014) 'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'. Gut microbes, 5 (5):669-674 [DOI] [Details]
	(2013)	'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation' S. Renier, C. Chagnot, J. DeschampS, N. Caccia, J. Szlavik, S. A. Joyce, M. Popowska, C. Hill S. Knochel, R. Briandet, M.Hebart and M. Deesvaux (2013) 'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'. Environmental Microbiology, 16 (4):1176-1192 [DOI] [Details]
	(2013)	'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection' J. Cummins, P. G. Casey , S. A. Joyce, and C. G.M. Gahan (2013) 'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'. Plos One, 12 (8) [Full Text] [Details]
	(2013)	'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome' PM Pereira-Fantini, S Lapthorne, SA Joyce, NL Dellios, G Wilson, F Fouhy, Colin Hill, Cormac G. M. Gahan, Paul D. Cotter, Peter J. Fuller, Winita Hardikar, Julie E. Bines (2013) 'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'. European Journal of Gastroenterology & Hepatology, 28 :14-15 [Details]
	(2012)	'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes' McLaughlin, Heather P.,Xiao, Qiaobin,Rea, Rosemarie B.,Pi, Hualiang,Casey, Pat G.,Darby, Trevor,Charbit, Alain,Sleator, Roy D.,Joyce, Susan A.,Cowart, Richard E.,Hill, Colin,Klebba, Phillip E.,Gahan, Cormac G. M. (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. PLoS ONE, 7 (2)   [DOI] [Full Text] [Details]
	(2012)	'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting' Cronin, M.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J. B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'. Plos One, 7 (11)   [Full Text] [Details]
	(2011)	'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens' Joyce S.;Lango L.;Clarke D. (2011) 'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens'. Advances In Applied Microbiology, 76 :1-25 [DOI] [Details]
	(2011)	'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile' Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
	(2010)	'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics' Collins, B. and Joyce, S. and Hill, C. and Cotter, P.D. and Ross, R.P. (2010) 'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'. Antimicrobial agents and chemotherapy, 54 (11):4658-4663 [Details]
	(2010)	'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus' Eleftherianos, I,Joyce, S,Ffrench-Constant, RH,Clarke, DJ,Reynolds, SE; (2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'. Parasitology, 137 :1695-1706 [DOI] [Details]
	(2010)	'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01' Watson, Robert J.,Millichap, Peter,Joyce, Susan A.,Reynolds, Stuart,Clarke, David J. (2010) 'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
	(2010)	'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens' Easom, Catherine A.; Joyce, Susan A.; Clarke, David J. (2010) 'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
	(2010)	'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment' Jones, Robert T.,Sanchez-Contreras, Maria,Vlisidou, Isabella,Amos, Matthew R.,Yang, Guowei,Muñoz-Berbel, Xavier,Upadhyay, Abhishek,Potter, Ursula J.,Joyce, Susan A.,Ciche, Todd A.,Jenkins, A. Toby A.,Bagby, Stefan,ffrench-Constant, Richard H.,Waterfield, Nicholas R. (2010) 'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
	(2009)	'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)' Plichta, K. L., Joyce, S. A., Clarke, D. J., Waterfield, N. and Stock, S. P. ; (2009) 'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'. Journal of Helminthology, 16 :1-12 [Details]
	(2008)	'Bacterial biosynthesis of a multipotent stilbene' Joyce, S. A.,Brachmann, A. O.,Glazer, I.,Lango, L.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2008) 'Bacterial biosynthesis of a multipotent stilbene'. Angew Chem Int Ed Engl, 47 (10):1942-5 [Details]
	(2007)	'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition' Eleftherianos, Ioannis; Boundy, Sam; Joyce, Susan A.; Aslam, Shazia; Marshall, James W.; Cox, Russell J.; Simpson, Thomas J.; Clarke, David J.; ffrench-Constant, Richard H.; Reynolds, Stuart E. (2007) 'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'. Proceedings of The National Acadamy of Sciences, 104 (7):2419-24   [DOI] [Details]
	(2007)	'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens' Brachmann, A. O.,Joyce, S. A.,Jenke-Kodama, H.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2007) 'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'. Chembiochem, 8 (14):1721-8 [Details]
	(2006)	'Nematode Symbiont for Photorhabdus asymbiotica' Gerrard, John; Joyce, Susan; Clarke, David; ffrench-Constant, Richard; Nimmo, Graeme; Looke, David, F. M.; Feil, Edward; Pearce, Lucy; Waterfield, Nick (2006) 'Nematode Symbiont for Photorhabdus asymbiotica'. Emerging Infectious Disease Journal, 12 (10):1562-1564   [DOI] [Full Text] [Details]
	(2006)	'The regulation of pathogenicity and mutualism in Photorhabdus' Joyce, S. A.,Watson, R. J.,Clarke, D. J.; (2006) 'The regulation of pathogenicity and mutualism in Photorhabdus'. Curr Opin Microbiol, 9 (2):127-32 [Details]
	(2005)	'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis' Watson, R. J.,Joyce, S. A.,Spencer, G. V.,Clarke, D. J.; (2005) 'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'. Mol Microbiol, 56 (3):763-73 [Details]
	(2003)	'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation' Joyce, S. A.,Clarke, D. J.; (2003) 'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'. Mol Microbiol, 47 (5):1445-57 [Details]
	(2003)	'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen' ffrench-Constant R, Waterfield N, Daborn P, Joyce S, Bennett H, Au C, Dowling A, Boundy S,Reynolds S, Clarke D. (2003) 'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'. Fems Microbiology Letts, [Details]
	(2002)	'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli' Joyce SA, Dorman CJ. (2002) 'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'. Molecular Microbiology, 45 (4):1107-1117 [Details]
	(2002)	'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12' Clarke, D. J.,Joyce, S. A.,Toutain, C. M.,Jacq, A.,Holland, I. B.; (2002) 'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'. J Bacteriol, 184 (4):1204-8 [Details]
	(2000)	'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome' Beletskii A, Grigoriev A, Joyce S, Bhagwat AS. (2000) 'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'. Journal of Molecular Biology, 300 :1057-1065 [Details]
	(1999)	'5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation' Joyce, S. A. and Dreyfus M.D (1999) '5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'. Journal of Molecular Biology, 282 :241-254 [Details]
	(1999)	'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo' Lopez PJ, Marchand I, Joyce SA, Dreyfus M (1999) 'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'. Molecular Microbiology, 33 :188-199 [Details]
	(1994)	'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes' Joyce, Susan A.; Burnell, Ann M.; Powers, Thomas O. (1994) 'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'. Journal of Nematology, 26 (3):260-270   [Full Text] [Details]

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Note

	Year	Publication
	(2008)	Photorhabdus: Shedding light on. Joyce S.;Clarke D. (2008) Photorhabdus: Shedding light on. Note [Details]

‍

Reviews

	Year	Publication
	(2016)	The impact of the gut microbiota on drug metabolism and clinical outcome. Enright E.;Gahan C.;Joyce S.;Griffin B. (2016) The impact of the gut microbiota on drug metabolism and clinical outcome. Reviews [Details]

‍

Professional Activities

‍

Professional Associations

	Association	Function	From / To
	COST Action NutRedOx	Member	01-JUN-19 /
	COST Action EpiLipidNET	Member	01-JUN-21 /
	Interview Board /Panel for Teasgasc	Interview Board /Panel for Teasgasc	/
	Atlantia Clinical Studies Science Advisory role	Science Advisory role	/
	Irish Mass Spectrometry Society Committee	Secretary Committee/Management member	/
	Metabolomics Society	Interaction	29-JAN-17 /
	Biochemical Society	Member	01-JAN-00 /
	Society for General Microbiology	Member	01-JAN-00 /

‍

Patents

	Patent Number	Title	Granted
	11194PC00 EPO	METHODS OF REGULATING WEIGHT GAIN	12-JUN-14

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Disclosures

	Title	Inventor	Submitted
	Behaviour altering Microbia	with APC Microbiome Ireland

‍

Committees

	Committee	Function	From / To
	2021 APC Microbiome Ireland Annual conference	Organizing committee	/
	2021 IMSS Annual Meeting Organizing Committee	Committee member	/
	Research Committee -School and College	Chair - School, Member - College	2020 /
	Graduate Studies Committee- School Level	Committee member	2019 /
	Athena Swan SAT	Group Task leader	2020 /
	Medicine & Health Degree Curriculum Committee	Curriculum and Programme development	2019 /
	Exam Board SOM	Information, co-ordination, Standards	2015 /
	Scientific Advisory Board Pavol Jozef Šafárik University in Slovakia	Grants, Science advisory	/
	Grant reviewer Agence Nationale de la Recherche	Grant Reviewer	2021 /
	Grant Reviewer European Science Foundation	Grant Reviewer	2020 /
	2019 FWO Grant reviewer for Belgian public research funding organisation	2019 FWO Grant reviewer for Belgian public research funding organisation	/
	Reviewer for • The Austrian Science Fund	Grant reviewer	2017 /
	In House Institute Pasteur Grant Reviewer	Grant reviewer -intermittently	2016 /
	Independent Chair PhD examination	Independent Chair	2020 /
	External Examiner Institute Pasteur PhD Thesis	Examiner	2020 /
	PhD thesis Examiner	Internal Examination	2019 /
	Teaching Review Commitee	Report construction	2015 /

‍

Education

	Year	Institution	Qualification	Subject
	2020	Cold Spring Harbour (Online)	Certificate in Proteomics	Proteomics
	2011	Waters Ltd	Certificate Small Molecule Detection and Analysis	Small Molecule Detection and Analysis
	2011	UCC	Post Graduate Cert in Education	Teaching & Learning
	2007	Bath University	Certificate in Management	Management
	2008	LAST Ireland	Certificate - Animal studies	Animal Handling and Regulations

‍

Languages

	Language	Reading	Writing	Speaking
	English	Fluent	Fluent	Fluent
	French	Fluent	Functional	Fluent

‍

Outreach Activities

	Description
	2018 BBC4 Podcast The second genome >6Million Downloads
	2021 Public On line Seminar Can we shape our microbiomes with food and viruses
	2021 Career Journey presentation and discussion to Post Docs APC Microbiome Ireland
	Jan 2019 -News paper article: Research to lay public: https://www.farminglife.com/business/ps750k-funding-three-agri-food-research-projects-137587
	2019 Cornstore Restaurant Limerick - Food for health
	Cornstore restaurant Cork- Food for health 2018 Talks to general public on obesity and Microbiome research
	2018 Ambassador Aurora Leadership Programme for women
	Cork City Gaol - Talks -Science week 2016
	December 2015: Food for health https://www.irishtimes.com/news/science/keep-the-christmas-dinner-safe-from-merry-microbes-1.2457464
	2014 RTE News: Gut microbes and Obesity https://www.rte.ie/news/2014/0506/615513-ucc-bacteria-obesity/
	2014: Obesity and Gut bacteria https://www.irishexaminer.com/news/arid-20267601.html
	World IBD Day Talk 2014 - talk and discussion with patients CUH
	Hosting TY students
	Demonstration and talks on gut Health
	Open Science Exhibition 2015 CIT
	Education and Outreach Committee member APC Microbiome Institute

‍

Journal Activities

	Journal	Role	To / From
	Frontiers In Nutrition	Editor	-
	Scientific Reports	Referee	-
	Journal Of Receptors And Signal Transduction	Referee	-
	Bmc Genomics	Referee	-
	Future Microbiology	Referee	-
	Infection And Immunity	Referee	-
	Journal Of Functional Foods	Referee	-
	Journal Of Applied Microbiology	Referee	-
	Letters In Applied Microbiology	Referee	-
	Plos One	Referee	-

‍

Other Activities

	Description
	Investigator APC Microbiome Ireland: Funded research,  reporting, interaction and delivery on SFI funded activities within the center
	Invited member of the Pharmabiotic Research Institute France – links industry to individuals and determines strategy in Europe for microbiome and gut health
	2019 Hosted Dalila Paladino Erasmus student
	Hosted Exchange PhD studentDr Roberta Prete – Italy – 18 months
	2018 Hosted Jinchi Jiang – China –12 months- registered with SEFS Chinese government Scholar
	2018 Hosted Erasmus student Silvia Palladinelli – Italy-6 months
	Microbiology Society microbiome research stakeholder Forum, including government ministers,  workshop in Dublin on 15th November 2016 in order to determine strategies in microbiome research for the future.

‍

Teaching Activities

‍

Teaching Interests

• Currently main supervisor to 4 PhD students.
• Main supervisor to 1 MSc.
• Co-supervisor to 3 PhD students.
• Direct the work of 2 Post doctoral scientists
• Direct the work of 2 senior RAs

‍

Recent Postgraduates

	Graduation Year	Student Name	Institution	Degree Type	Thesis Title
	2021	Shane O'Dwyer	UCC	MSc	The microbiome in aging
	2021	David Cussens	UCC	MSc	C.elegans and the microbiome in aging
	2020	Jonathan Keane	NUI (UCC)	PHD	Changes in the gut microbiota in CRC- cause or consequence
	2020	Ciara O'Donovan	NUI (UCC)	PHD
	2019	Sam Walsh	UCC	MSc	MSc Aging in C.elegans - a microbial perspective
	2020	Elaine Enright	NUI (UCC)	PHD	Gut microbiota mediated bile acid metabolism
	2019	Peter Cronin	UCC	M.Sc. (with distinction)	MRes Metabolism in CRC -
	2019	Sarah Louise Long	UCC	PHD DOCTOR OF PHYSICAL SCIENCES	Bacterial Bile salt Hydrolase - from selection to impact
	2018	Ashling Clifford	UCC	MSc	Cloning and expression of bile altering enzymes
	2017	Maurice Stanley	UCC	MSc	MRes: Diet effects in genetic and chemical models of IBD
	2015	Sarah Conroy	UCC	MSc
	2014	Stephen Butler	UCC	MSc
	2014	Sinead Griffin	UCC	MSc
	2013	Aoife Redmond	UCC	MSc
	2012	Ciara Morgan	UCC	MSc
	2012	Catherine Easom	UCC	PHD

‍

Current Postgraduate Students

	Student	Degree Type
	Killian Christina Jane	Doctoral Degree
	Saiz Gonzalo Gonzalo	Doctoral Degree
	Wall Katie Danielle	Doctoral Degree

‍

Modules Taught

	Term (ID))	Title	Link	Subject
	2022	Advanced Metabolism in Health, Disease and Cancer	BC3002	Advanced Metabolism in Health, Disease and Cancer
	2022	Molecular Biology and Gene Regulation in Health and Disease	BC2024	Molecular Biology and Gene Regulation in Health and Disease
	2022	Advanced Metabolism in Health, Disease and Cancer	BC4016	Advanced Metabolism in Health, Disease and Cancer
	2022	Foundations of Medicine 4 - Gastrointestinal, Nutritional and Metabolic Biology	FM1040	Foundations of Medicine 4 - Gastrointestinal, Nutritional and Metabolic Biology
	2022	Gastrointestinal, Nutritional and Metabolic Biology	MH1040	Gastrointestinal, Nutritional and Metabolic Biology

‍

Research Information

‍

Internal Collaborators

	Name	Institute	Country
	Dr David Clarke	School of Microbiology	IRELAND
	Prof John Cryan	UCC	IRELAND
	Prof Dmitri Papkovsky	UCC	IRELAND
	Prof Jens Walter	UCC	IRELAND
	Dr Dervla O'Malley	UCC	IRELAND
	Dr Marcus Claesson	UCC
	Dr Cora O'Neill	UCC
	Dr Niall Hyland	UCC
	Dr David Clarke	UCC
	Dr Silvia Melgar	APC Microbiome Institute
	Dr Aileen Houston	CUH/ UCC
	Prof Nicole Roy	New Zealand	NEW ZEALAND

‍

External Collaborators

	Name	Organisation / Institute	Country
	Dr Carel La Roux	UCD	IRELAND
	Prof Paul Cotter	Teagasc Moorepark	IRELAND
	Dr Eibhlis O'Connor	University of Limerick	IRELAND
	Dr Kieran Tuohy	FEMS Italy
	Dr Julie Lovegrove	University of Reading
	Dr Orla O'Sullivan	Teagasc, Moorepark	IRELAND
	Dr Irina Tikonova	Queens University of Belfast	UNITED KINGDOM
	Prof. Jun Lin	University of Knoxville	U.S.A.
	Dr Prue Pereira	Murdochs Childrens Research Institute	AUSTRALIA