Research Profile

Susan Joyce

Biography

Dr Susan Joyce  (H index=44, >5500 citations) graduated with a B.Sc (joint hons) from Maynooth University in Biology and Mathematics and a research PhD in host-microbe interactions. She was awarded a Marie Curie Fellowship to examine cis and trans acting factors affecting mRNA synthesis and  gene expression at the Ecole Normal Superieure, Paris which included a stint at the Max Planck Institute, Berlin. Before returning to UCC, Dr Joyce was a postdoctoral scientist at Trinity College Dublin and at the Univerity of Bath, UK. 
Susan Joyce (BSc, PhD, CM, PGCE) is Faculty at UCC and a PI in the UCC Food Institute and an investigator in APC Microbiome Ireland Health. Her research interests revolve around metabolism and altered human, host and microbial metabolic pathways, with food,  that can influence health and disease. She leads a metabolomics focused research group in diverse areas of host response through small molecule analysis (MS applications), cellular systems, gene expression and signalling readout, clinical interphase, microbial associations in terms of strain isolation, functional and phenotypic characterization including their metabolites and genetics,  Areas currently  under investigation include (1)  metabolomic approach to identify novel biomarkers of microbial  dietary ingredients in fermentation  and (2) metabolomic signatures in deciphering health and ageing (3) specific microbial enzyme inhibition and applications to alter metabolomic signatures towards healthy weight gain.  Susan is a recipient of DAFM funding. She is a partner in the FP7 project SOPHIA, with a focus on obesity. She represents her School and APC Microbiome Ireland in the Joint Programming Initiative (JPI) CABALA for health, where she is a partner. She has published over 90  publications including publications in leading journals including Angewande chemie.  PNAS, GUT, J Hepatol and Nature Comms. She regularly serves as a reviewer for international grant awards and for international journals and she is serving as an associate editor Frontiers in Nutrition and Editorial Board of Liver Research. She is actively involved in undergraduate and postgraduate teaching and research, and delivers a range of lectures in genetics, and in advanced metabolism at all BSc levels, and to school of medicine students. She is co-director of MRes in Biochemistry and Cell Biology AY21-22, Director of MRes in Biochemistry and Biosciences commencing AY22.  She is vice-chair of the Irish Mass Spectrometry Society (IMSS).  Her full publication list is available at: http://orcid.org/0000-0003-4771-3123 and at https://scholar.google.com/citations?hl=en&user=6KpVtU0AAAAJ

Research Interests

My research focuses on elucidating the genetic and biochemical basis of host-microbe interactions, their regulation and outcomes.

RESEARCH GROUP OVERVIEW: The Gut and its microbiota ( in health and disease) is shaped by diet, environment and gut microbial changes as well as by host genetics.  The influence of these combined factors contributes to processes including gut development and homeostasis, immune function and local and systemic signalling in defining health outcomes.

My group dissects how these different and combined factors can impact health, disease and longevity. The group has focused on microbial host-metabolite and dietary modification that impact the host  (including drug uptake, adiposity, circadian rhythm, immune functions) with a particular emphasis on signalling processes to identity key areas for therapeutic approaches.  We apply targeted and untargeted metabolomic approaches, animal models, cell systems and bacterial molecular and cellular biology to address our questions.

We investigate and pursue:
  • Mechanistic understanding of food enrichment for specific classes of microbes and their fitness to function
  • Understanding of the alternative lifestyles of microbes in the gut, what makes a commensal become a pathobiont?
  • How microbial metabolism of diet and host produced factors reprogramme cell and metabolic processes
  • The interactions between food-microbes and their hosts towards disease and in maintaining health
  • Simply defining health, in the context of microbial functions and modification of metabolites to influence cell signalling processes
  • Drugs and bugs - re-potentiating mechanisms



Research Grants

 ProjectFunding
Body
Start DateEnd DateAward
BSH inhibition for animal husbandry optimization (BIAHOP)Irish Research Council01-SEP-2231-AUG-24€99,513.00
OMITHorizon 202009-NOV-2008-NOV-22€196,591.00
HEACOVID1901-APR-2131-JUL-21€5,933.00
HEACOVID1901-APR-2131-JUL-21€16,875.00
HEACOVID1901-APR-2131-AUG-21€11,298.00
SOPHIA “Stratification of Obese Phenotypes to Optimize Future Obesity Therapy”Horizon 202001-JUN-2031-MAY-25€20,000.00
HEACOVID1901-DEC-2030-APR-21€17,117.00
Redressing the Impact of Industrialization on Gut Microbiome Composition and Function (Microbe Restore)Science Foundation of Ireland01-NOV-2031-OCT-25€205,000.00
APC4 12/RC/2273_P2 Spoke 4 Microbe Dialogue: Aim 4.2bScience Foundation of Ireland01-JUN-1931-MAY-25€515,278.00
APC4_12/RC/2273_P2 - TP Pepsico - Susan JoyceSFI Industry01-JUL-1931-AUG-21€155,865.00
SFI 12-RC-2273_P2 IND Pepsico TP"Fermented Oat Dairy Project" Dr Susan Joyce [X]SFI Industry01-JUN-1931-MAR-20€61,113.00
An Analysis of the Role of Eraly Gut Colonizers, E-coli and Bacteroides, In Bile Acid Metabolism.Irish Research Council01-SEP-1931-JAN-24€105,333.00
Improved animal husbandry through inhibition of microbial bile salt hydrolase (NAGpro)Department of Agriculture Fisheries & Forestry (DAFF)01-NOV-1831-MAY-22€301,874.00
Fermented Oat Dairy ProductSFI Industry01-NOV-1831-MAY-19€11,037.00
The effect of PepsiCo prebiotic in cases of mild to moderate hypercholesterolemiaIndustry01-SEP-1831-MAY-19€95,890.00
Unravelling the metabolic etiology of inflammatory bowel disease (IBD) via lipidome, metabolome and microbiome multivariate analysisMiscellaneous05-NOV-1831-OCT-21€72,800.00
Lily Research ScholarshipIrish Funded Research01-OCT-1710-JUN-22€111,080.00
ERA HDHL-ERA-Net on Biomarkers for Nutrition and Health.Science Foundation of Ireland01-JAN-1731-DEC-20€249,600.00
Science Foundation Ireland; Infrastructure Category D, Opportunistic Funds; R17475 is the main projectScience Foundation of Ireland01-JAN-1730-JUN-19€30,828.00
The microbiome in the context of IBD01-OCT-1601-MAR-22€93,000.00
Janssen contribution to a targeted project part funded by SFI under 12/RC/2273 (APC3 Research Centre)SFI Industry15-FEB-1601-JUL-17€144,461.00
Microbiota and Colorectal Cancer -Cause or consequence01-OCT-1501-OCT-19€93,000.00
Bacterial Bile Salt hydrolase: from selection to impact on host metabolism and microbiota01-OCT-1530-SEP-19€151,000.00
Exploring clues from the changing phenotype of Crohns DiseaseHealth Research Board01-OCT-1330-SEP-16
APC Microbiome Institute Spoke 4A Host Microbe DialogueScience Foundation Ireland01-JUN-1331-MAY-19

Contract Researchers

 Researcher NameProjectRoleFunding Body
2022- Current Dr Sourav Roy ChoudhuryAPC 4 Theme 4Academic Sponsor
2021-current Mr Darragh Mattimoe2 sequential projects: Industry & APC theme 4Academic SponsorIndustry Sponsor
2021- 2021 Dr Amed KabirIndustry - 9 month projectAcademic SponsorIndustry Sponsor
2019- current Dr Karim Hayoun2 sequential projects: DAFM- NAG Pro & IRC commencing 2022Academic SponsorDepartment of Agriculture, Fisheries & Food (DAFF)
2019-2021 Dr Anirudh Jaisimha2 sequential Projects: APC theme 4 & Cabala for health JPI: SFI-EUPostdoctoral ResearcherScience Foundation Ireland
2018-current Dr Eileen Ryan2 sequential Projects: IBD-ome APEX Fellow to 2021 & MCRA Fellow "OMIT" from 2021Postdoctoral ResearcherEuropean Commission
2015-2021 Mr Alvaro Lopez GallardoAPC 3 Spoke 4Academic Sponsor

Publications

Abstract

 YearPublication
(2017)Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism.
Golubeva, A;Joyce, S;Moloney, G;Burokas, A;Sherwin, A;Arboleya, S;Murphy, K;Hyland, N;Stanton, C;Clarke, G;Gahan, C;Dinan, T;Cryan, J (2017) Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. HOBOKEN: Abstract [Details]
(2015)Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model.
Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fouhy, F;Scurr, M;Cotter, PD;Gahan, CG;Bines, JE (2015) Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model. HOBOKEN: Abstract [Details]
(2015)Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease.
Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fuller, PJ;Bines, JE (2015) Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease. HOBOKEN: Abstract [Details]

Encyclopedia Entries

 YearPublication
Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.
Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression. . Encyclopedia Entries. [DOI] [Details]

Peer Reviewed Journals

 YearPublication
(2022)'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication'
Joyce, Susan A.;O'Malley, Dervla (2022) 'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication'. Journal of Physiology-London, [DOI] [Full Text] [Details]
(2021)'Dietary Fibre Modulates the Gut Microbiota'
Cronin P;Joyce SA;O'Toole PW;O'Connor EM; (2021) 'Dietary Fibre Modulates the Gut Microbiota'. Nutrients, 13 (5) [DOI] [Details]
(2021)'Concentrations of Fecal Bile Acids in Participants with Functional Gut Disorders and Healthy Controls'
James SC;Fraser K;Young W;Heenan PE;Gearry RB;Keenan JI;Talley NJ;Joyce SA;McNabb WC;Roy NC; (2021) 'Concentrations of Fecal Bile Acids in Participants with Functional Gut Disorders and Healthy Controls'. Metabolites, 11 (9) [DOI] [Details]
(2021)'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli'
Duysburgh C;Van den Abbeele P;Kamil A;Fleige L;De Chavez PJ;Chu Y;Barton W;O'Sullivan O;Cotter PD;Quilter K;Joyce SA;Murphy M;DunnGalvin G;Dinan TG;Marzorati M; (2021) 'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli'. Pathogens (Basel, Switzerland), 10 (2) [DOI] [Details]
(2020)'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer'
Keane, Jonathan M.; Joyce, Susan A.; Gahan, Cormac G. M.; Hyland, Niall P.; Houston, Aileen (2020) 'Microbial metabolites as molecular mediators of host-microbe symbiosis in colorectal cancer'. Results And Problems In Cell Differentiation, 69 [DOI] [Full Text] [Details]
(2020)'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions'
Enright E.F.;Joyce S.A.;Gahan C.G.M.;Taylor L.S. (2020) 'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions'. European Journal Of Pharmaceutics And Biopharmaceutics, 153 :68-83 [DOI] [Details]
(2020)'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities'
Prete, Roberta; Long, Sarah L.; Joyce, Susan A.; Corsetti, Aldo (2020) 'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities'. Fems Microbiology Letters, [DOI] [Full Text] [Details]
(2020)'Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer'
Keane J.M.;Joyce S.A.;Gahan C.G.M.;Hyland N.P.;Houston A. (2020) 'Microbial Metabolites as Molecular Mediators of Host-Microbe Symbiosis in Colorectal Cancer'. Results And Problems In Cell Differentiation, 69 :581-603 [DOI] [Full Text] [Details]
(2020)'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease'
Ryan F.J.;Ahern A.M.;Fitzgerald R.S.;Laserna-Mendieta E.J.;Power E.M.;Clooney A.G.;O’Donoghue K.W.;McMurdie P.J.;Iwai S.;Crits-Christoph A.;Sheehan D.;Moran C.;Flemer B.;Zomer A.L.;Fanning A.;O’Callaghan J.;Walton J.;Temko A.;Stack W.;Jackson L.;Joyce S.A.;Melgar S.;DeSantis T.Z.;Bell J.T.;Shanahan F.;Claesson M.J. (2020) 'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease'. Nature Communications, 11 (1) [DOI] [Full Text] [Details]
(2020)'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system'
Geng W.;Long S.L.;Chang Y.J.;Saxton A.M.;Joyce S.A.;Lin J. (2020) 'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
(2020)'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin'
Prete R.;Long S.;Gallardo A.;Gahan C.;Corsetti A.;Joyce S. (2020) 'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
(2019)'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection'
Mullish B.;McDonald J.;Pechlivanis A.;Allegretti J.;Kao D.;Barker G.;Kapila D.;Petrof E.;Joyce S.;Gahan C.;Glegola-Madejska I.;Williams H.;Holmes E.;Clarke T.;Thursz M.;Marchesi J. (2019) 'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection'. Gut, [DOI] [Full Text] [Details]
(2019)'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome'
O’Donovan S.;Crowley E.;Brown J.;O’Sullivan O.;O’Leary O.;Timmons S.;Nolan Y.;Clarke D.;Hyland N.;Joyce S.;Sullivan A.;O'Neill C. (2019) 'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome'. Neurogastroenterology and Motility, [DOI] [Details]
(2019)'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome'
Susan A. Joyce, Alison Kamil, Lisa Fleige and Cormac G. M. Gahan (2019) 'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome'. Frontiers in Nutrition, 6 [DOI] [Details]
(2019)'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'
Ryan, PM;Stolte, EH;London, LEE;Wells, JM;Long, SL;Joyce, SA;Gahan, CGM;Fitzgerald, GF;Ross, RP;Caplice, NM;Stanton, C (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC Microbiology, 19 [DOI] [Details]
(2018)'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'
Enright EF;Govindarajan K;Darrer R;MacSharry J;Joyce SA;Gahan CGM; (2018) 'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'. Molecular Pharmaceutics, [DOI] [Details]
(2018)'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'
Laserna-Mendieta, EJ;Clooney, AG;Carretero-Gomez, JF;Moran, C;Sheehan, D;Nolan, JA;Hill, C;Gahan, CGM;Joyce, SA;Shanahan, F;Claesson, MJ (2018) 'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'. Journal Of Crohns & Colitis, 12 :204-216 [DOI] [Details]
(2018)'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'
Brown, JRM;Flemer, B;Joyce, SA;Zulquernain, A;Sheehan, D;Shanahan, F;O'Toole, PW (2018) 'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'. BMC Gastroenterology, 18 [DOI] [Details]
(2018)'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'
Enright, E.F. and Griffin, B.T. and Gahan, C.G.M. and Joyce, S.A. (2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'. Pharmacological Research, 133 :170-186   [DOI] [Details]
(2017)'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'
Golubeva AV;Joyce SA;Moloney G;Burokas A;Sherwin E;Arboleya S;Flynn I;Khochanskiy D;Moya-Pérez A;Peterson V;Rea K;Murphy K;Makarova O;Buravkov S;Hyland NP;Stanton C;Clarke G;Gahan CGM;Dinan TG;Cryan JF; (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. Ebiomedicine, 24 [DOI] [Details]
(2017)'Pathophysiologic gut hormone and bile acid signalling after oesophagectomy: implications for appetite, postprandial hypoglycaemia and nutritional status in survivorship'
Elliott, J.A., Murphy, C.F., Docherty, N.G., Doyle, S.L., Gallardo, A.L., Gahan, C., Joyce, S., Ravi, N., Reynolds, J.V. and le Roux, C.W. (2017) 'Pathophysiologic gut hormone and bile acid signalling after oesophagectomy: implications for appetite, postprandial hypoglycaemia and nutritional status in survivorship'. International Journal Of Surgery, s (S91):91-91 [Details]
(2017)'Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., 2017. Mechansims Underpinning Successful Faecal Microbiota Transplantation (FMT) for Recurrent Clostridium Difficile Infection'
Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., (2017) 'Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., 2017. Mechansims Underpinning Successful Faecal Microbiota Transplantation (FMT) for Recurrent Clostridium Difficile Infection'. BMC Gastroenterology, 152 (5) [Details]
(2017)'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'
Langer, Angela; Moldovan, Adriana; Harmath, Christian; Joyce, Susan A.; Clarke, David J.; Heermann, Ralf (2017) 'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'. Plos One, 12 (4):1-23 [DOI] [Full Text] [Details]
(2017)'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'
Joyce SA;Gahan CG; (2017) 'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'. Journal of Digestive Diseases, 35 (3) [DOI] [Details]
(2017)'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'
Golubeva, Anna V.,Joyce, Susan A.,Moloney, Gerard,Burokas, Aurelijus,Sherwin, Eoin,Arboleya, Silvia,Flynn, Ian,Khochanskiy, Dmitry,Moya-Pérez, Angela,Peterson, Veronica,Rea, Kieran,Murphy, Kiera,Makarova, Olga,Buravkov, Sergey,Hyland, Niall P.,Stanton, Catherine,Clarke, Gerard,Gahan, Cormac G. M.,Dinan, Timothy G.,Cryan, John F. (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. EBioMedicine, 24 :166-178   [DOI] [Full Text] [Details]
(2017)'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'
Pereira-Fantini, Prue M.; Lapthorne, Susan; Gahan, Cormac G. M.; Joyce, Susan A.; Charles, Jenny; Fuller, Peter J.; Bines, Julie E. (2017) 'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'. Cellular And Molecular Gastroenterology And Hepatology, 4 (1):65-74 [DOI] [Full Text] [Details]
(2017)'Interactions between gut bacteria and bile in health and disease'
Long SL;Gahan CGM;Joyce SA; (2017) 'Interactions between gut bacteria and bile in health and disease'. Molecular aspects of medicine, 56 [DOI] [Details]
(2017)'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'
Nilaweera, KN;Cabrera-Rubio, R;Speakman, JR;O'Connor, PM;McAuliffe, A;Guinane, CM;Lawton, EM;Crispie, F;Aguilera, M;Stanley, M;Boscaini, S;Joyce, S;Melgar, S;Cryan, JF;Cotter, PD (2017) 'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'. American Journal of Physiology (Endocrinology and Metabolism), 313 :1-11 [DOI] [Details]
(2016)'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'
Dowd GC;Bahey-El-Din M;Casey PG;Joyce SA;Hill C;Gahan CG; (2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'. Human Vaccines & Immunotherapeutics, [DOI] [Details]
(2016)'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'
Enright EF;Gahan CG;Joyce SA;Griffin BT; (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. The Yale journal of biology and medicine, 89 (3) [Details]
(2016)'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'
Joyce SA, Gahan CG. (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Food Science and Technology International, 7 (7):313-333 [DOI] [Details]
(2016)'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'
Joyce SA;Gahan CG; (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Annual Review Of Food Science And Technology, Vol 1, 7 [DOI] [Details]
(2016)'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'
Govindarajan, Kalaimathi; MacSharry, John; Casey, Patrick G.; Shanahan, Fergus; Joyce, Susan A.; Gahan, Cormac G. M. (2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'. Plos One, 11 (1212):e0167319-1-e0167319-13 [DOI] [Full Text] [Details]
(2016)'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'
Pereira-Fantini PM, Bines JE, Lapthorne S, Fouhy F, Scurr M, Cotter PD, Gahan CG, Joyce SA. (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Italian Journal of Gastroenterology and Hepatology, [DOI] [Details]
(2016)'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'
Govindarajan, Kalaimathi,MacSharry, John,Casey, Patrick G.,Shanahan, Fergus,Joyce, Susan A.,Gahan, Cormac G. M. (2016) 'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'. PLoS ONE, 11 (12)   [DOI] [Full Text] [Details]
(2016)'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'
Nolan JA, Kinsella M, Hill C, Joyce SA, Gahan CG. (2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'. Current Microbiology, [DOI] [Details]
(2016)'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'
Pereira-Fantini PM;Bines JE;Lapthorne S;Fouhy F;Scurr M;Cotter PD;Gahan CG;Joyce SA; (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Journal of gastroenterology and hepatology, [DOI] [Details]
(2016)'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'
Enright, E.F., ,Gahan, C.G.M.,Joyce, S.A.,Griffin, B.T. (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. Yale Journal Of Biology And Medicine, 89 :375-382 [Full Text] [Details]
(2016)'Disease-associated changes in bile acid profiles and links to altered gut microbiota'
S.A Joyce and C.G. Gahan (2016) 'Disease-associated changes in bile acid profiles and links to altered gut microbiota'. Digestive Diseases, [DOI] [Details]
(2014)'The gut microbiota and the metabolic health of the host'
Joyce SA, Gahan CG (2014) 'The gut microbiota and the metabolic health of the host'. Current opinion in gastroenterology, 30 (2):120-127 [DOI] [Details]
(2014)'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'
Renier, S;Chagnot, C;Deschamps, J;Caccia, N;Szlavik, J;Joyce, SA;Popowska, M;Hill, C;Knochel, S;Briandet, R;Hebraud, M;Desvaux, M (2014) 'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'. Environmental Microbiology, 16 :1176-1192 [DOI] [Details]
(2014)'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'
Pereira-Fantini, PM,Lapthorne, S,Joyce, SA,Dellios, NL,Wilson, G,Fouhy, F,Thomas, SL,Scurr, M,Hill, C,Gahan, CGM,Cotter, PD,Fuller, PJ,Hardikar, W,Bines, JE (2014) 'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of hepatology, 61 :1115-1125 [DOI] [Details]
(2014)'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'
Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CG (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 (20):7421-7426 [DOI] [Details]
(2014)'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'
Susan A. Joyce, Fergus Shanahan, Colin Hill, Cormac G.M. (2014) 'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'. Gut microbes, 5 (5):669-674 [DOI] [Details]
(2013)'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'
S. Renier, C. Chagnot, J. DeschampS, N. Caccia, J. Szlavik, S. A. Joyce, M. Popowska, C. Hill S. Knochel, R. Briandet, M.Hebart and M. Deesvaux (2013) 'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'. Environmental Microbiology, 16 (4):1176-1192 [DOI] [Details]
(2013)'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'
J. Cummins, P. G. Casey , S. A. Joyce, and C. G.M. Gahan (2013) 'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'. Plos One, 12 (8) [Full Text] [Details]
(2013)'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'
PM Pereira-Fantini, S Lapthorne, SA Joyce, NL Dellios, G Wilson, F Fouhy, Colin Hill, Cormac G. M. Gahan, Paul D. Cotter, Peter J. Fuller, Winita Hardikar, Julie E. Bines (2013) 'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'. European Journal of Gastroenterology & Hepatology, 28 :14-15 [Details]
(2012)'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'
McLaughlin, Heather P.,Xiao, Qiaobin,Rea, Rosemarie B.,Pi, Hualiang,Casey, Pat G.,Darby, Trevor,Charbit, Alain,Sleator, Roy D.,Joyce, Susan A.,Cowart, Richard E.,Hill, Colin,Klebba, Phillip E.,Gahan, Cormac G. M. (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. PLoS ONE, 7 (2)   [DOI] [Full Text] [Details]
(2012)'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'
Cronin, M.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J. B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'. Plos One, 7 (11)   [Full Text] [Details]
(2011)'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens'
Joyce S.;Lango L.;Clarke D. (2011) 'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens'. Advances In Applied Microbiology, 76 :1-25 [DOI] [Details]
(2011)'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'
Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
(2010)'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'
Collins, B. and Joyce, S. and Hill, C. and Cotter, P.D. and Ross, R.P. (2010) 'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'. Antimicrobial agents and chemotherapy, 54 (11):4658-4663 [Details]
(2010)'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'
Eleftherianos, I,Joyce, S,Ffrench-Constant, RH,Clarke, DJ,Reynolds, SE; (2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'. Parasitology, 137 :1695-1706 [DOI] [Details]
(2010)'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'
Watson, Robert J.,Millichap, Peter,Joyce, Susan A.,Reynolds, Stuart,Clarke, David J. (2010) 'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
(2010)'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'
Easom, Catherine A.; Joyce, Susan A.; Clarke, David J. (2010) 'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
(2010)'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'
Jones, Robert T.,Sanchez-Contreras, Maria,Vlisidou, Isabella,Amos, Matthew R.,Yang, Guowei,Muñoz-Berbel, Xavier,Upadhyay, Abhishek,Potter, Ursula J.,Joyce, Susan A.,Ciche, Todd A.,Jenkins, A. Toby A.,Bagby, Stefan,ffrench-Constant, Richard H.,Waterfield, Nicholas R. (2010) 'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'. BMC Microbiology, 10 (1)   [DOI] [Full Text] [Details]
(2009)'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'
Plichta, K. L., Joyce, S. A., Clarke, D. J., Waterfield, N. and Stock, S. P. ; (2009) 'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'. Journal of Helminthology, 16 :1-12 [Details]
(2008)'Bacterial biosynthesis of a multipotent stilbene'
Joyce, S. A.,Brachmann, A. O.,Glazer, I.,Lango, L.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2008) 'Bacterial biosynthesis of a multipotent stilbene'. Angew Chem Int Ed Engl, 47 (10):1942-5 [Details]
(2007)'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'
Eleftherianos, Ioannis; Boundy, Sam; Joyce, Susan A.; Aslam, Shazia; Marshall, James W.; Cox, Russell J.; Simpson, Thomas J.; Clarke, David J.; ffrench-Constant, Richard H.; Reynolds, Stuart E. (2007) 'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'. Proceedings of The National Acadamy of Sciences, 104 (7):2419-24   [DOI] [Details]
(2007)'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'
Brachmann, A. O.,Joyce, S. A.,Jenke-Kodama, H.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2007) 'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'. Chembiochem, 8 (14):1721-8 [Details]
(2006)'Nematode Symbiont for Photorhabdus asymbiotica'
Gerrard, John; Joyce, Susan; Clarke, David; ffrench-Constant, Richard; Nimmo, Graeme; Looke, David, F. M.; Feil, Edward; Pearce, Lucy; Waterfield, Nick (2006) 'Nematode Symbiont for Photorhabdus asymbiotica'. Emerging Infectious Disease Journal, 12 (10):1562-1564   [DOI] [Full Text] [Details]
(2006)'The regulation of pathogenicity and mutualism in Photorhabdus'
Joyce, S. A.,Watson, R. J.,Clarke, D. J.; (2006) 'The regulation of pathogenicity and mutualism in Photorhabdus'. Curr Opin Microbiol, 9 (2):127-32 [Details]
(2005)'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'
Watson, R. J.,Joyce, S. A.,Spencer, G. V.,Clarke, D. J.; (2005) 'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'. Mol Microbiol, 56 (3):763-73 [Details]
(2003)'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'
Joyce, S. A.,Clarke, D. J.; (2003) 'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'. Mol Microbiol, 47 (5):1445-57 [Details]
(2003)'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'
ffrench-Constant R, Waterfield N, Daborn P, Joyce S, Bennett H, Au C, Dowling A, Boundy S,Reynolds S, Clarke D. (2003) 'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'. Fems Microbiology Letts, [Details]
(2002)'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'
Joyce SA, Dorman CJ. (2002) 'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'. Molecular Microbiology, 45 (4):1107-1117 [Details]
(2002)'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'
Clarke, D. J.,Joyce, S. A.,Toutain, C. M.,Jacq, A.,Holland, I. B.; (2002) 'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'. J Bacteriol, 184 (4):1204-8 [Details]
(2000)'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'
Beletskii A, Grigoriev A, Joyce S, Bhagwat AS. (2000) 'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'. Journal of Molecular Biology, 300 :1057-1065 [Details]
(1999)'5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'
Joyce, S. A. and Dreyfus M.D (1999) '5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'. Journal of Molecular Biology, 282 :241-254 [Details]
(1999)'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'
Lopez PJ, Marchand I, Joyce SA, Dreyfus M (1999) 'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'. Molecular Microbiology, 33 :188-199 [Details]
(1994)'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'
Joyce, Susan A.; Burnell, Ann M.; Powers, Thomas O. (1994) 'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'. Journal of Nematology, 26 (3):260-270   [Full Text] [Details]

Professional Activities

Honours and Awards

 YearTitleAwarding Body
20212021 Irish Research Council Ally Award Irish Research Council
20182018 Aurura Participation Award from UCC UCC
20132013 APC Microbiome Ireland Research Person APC Microbiome Ireland

Professional Associations

 AssociationFunctionFrom / To
2022: IFUT Committee Member Committee Member07-JUN-22 /
2022: EU Horizon Europe Application Evaluator Evaluator10-JUN-22 /
2021: Irish Mass Spectrometry Society Vice Chair Vice Chair01-DEC-21 /
2021: Director MRes Programme Biochemistry and Biosciences Transition of Vice Director to Director01-OCT-21 /
2021: Member COST Action EpiLipidNET Member01-JUN-21 /
2019: Member of COST Action NutRedOx Member01-JUN-19 /
2018: Secretary of Irish Mass Spectrometry Society Committee Secretary Committee/Management member01-DEC-19 / 01-DEC-21
2017+: Invited and trained Interview Board /Panel for Teasgasc Interview Board /Panel Teasgasc01-MAY-19 /
2017+: Member of Metabolomics Society Interaction29-JAN-17 /
2014: IFUT Member Committee Member01-JAN-14 /
2014+: Atlantia Clinical Studies Science Advisory role Science Advisory role01-JAN-14 /
2000: Member of Biochemical Society Member01-JAN-00 /
2000: Member of Microbiology Society Member01-JAN-00 /

Patents

 Patent NumberTitleGranted
11194PC00 EPO2014: METHODS OF REGULATING WEIGHT GAIN 12-JUN-14

Disclosures

 TitleInventorSubmitted
2021: Behaviour altering Microbia (with Cryan group) with APC Microbiome Ireland

Committees

 CommitteeFunctionFrom / To
2022: Independent Chair For Thesis Defence of Dr Tim Fass Independent Chair2022 /
2022: APC Microbiome Ireland EDI Committee Member2022 /
2022: External Evaluator to Waterford IT PhD Programme scholarship awards Evaluator2022 /
2021: IMSS Annual Meeting Organizing Committee Committee member2021 /
2021: Internal Examiner Thesis Commitee Dr David Goulding Thesis Commitee David Goulding2021 /
2021: Panel for Grant assessment of Waterford IT Excellence Awards Committee member2021 / 2021
2021: School of Biochemistry and Cell Biology EDI Committee member WG Lead2021 /
2021: Grant reviewer for Agence Nationale de la Recherche Grant Reviewer2021 /
2021: Member of Green Campus Intiative: Lab assessment Participant2021 / 2021
2021: Organizing Committee for online APC Microbiome Ireland Annual conference Organizing committee2021 /
2020: School of Biochemistry and Cell Biology Athena Swan SAT Bronze Award: WG Leader Group Task leader2020 /
2020; 2021: Interview and selection Panel SEFS WiSTEM2D Interview and selection2020 /
2020: Independent Chair PhD examination Dr Orla Power Independent Chair2020 /
2020: External Examiner Institute Pasteur Dr Nathalie Bechon PhD Thesis Examiner2020 /
2020: Member of Research and Innovation Committee SEFS Member2020 /
2019: Chair and Member of School of Biochemistry and Cell Biology Research Committee -School and College Chair - School, Member -2019 /
2019-2021: Medicine & Health Degree Curriculum Committee Curriculum and Programme development2019 / 2021
2019, 20, 21 Reviewer for European Science Foundation Reviewer2019 /
2019-21: ANR French National Research Agency Grant Reviewer Grant reviewer2019 / 2021
2019: FWO Grant reviewer for Belgian public research funding organisation 2019 FWO Grant reviewer for Belgian public research funding organisation2019 /
2019: PhD thesis Examiner Dr Sreeram Udayan Internal Examination2019 /
2018: Member Graduate Studies Committee- School Level Committee member2018 /
2018-22: onwards Scientific Advisory Board Pavol Jozef Šafárik University in Slovakia Grants, Science advisory2018 /
2017: Reviewer for The Austrian Science Fund Grant reviewer2017 /
2016: In House Institute Pasteur Grant Reviewer Grant reviewer -intermittently2016 /
2015-21 Direct Entry Medicine Yr1& 2 Examinations, Marks and Standards Examination Board School of Medicine Information, co-ordination, Standards2015 / 2021
2015: School of Biochemistry and Cell Biology Teaching Review Commitee Report construction2015 /

Education

 YearInstitutionQualificationSubject
2020Cold Spring Harbour (Online) 2020 Certificate in ProteomicsProteomics
2020LAST Ireland 2020 LAST Ireland Individual Investigators LicenceAnimal ethics and applications
2011UCC 2011 PGCE Post graduate Certificate in Teaching for learning and UnderstandingPedogogy of Teaching
2011Waters Ltd 2011 Certificate Small Molecule Detection and AnalysisSmall Molecule Detection and Analysis
2011UCC 2011 Post Graduate Cert in EducationTeaching & Learning
2007Bath University 2007 Certificate in ManagementManagement
2008LAST Ireland 2008 Certificate - Animal studiesAnimal Handling and Regulations

Languages

 LanguageReadingWritingSpeaking
English FluentFluentFluent
French FluentFunctionalFluent

Outreach Activities

 Description

Research News report https://www.bbc.com/news/world-europe-27294763

Demonstration and talks on gut Health

Hosting TY students either individually or in groups annually. Hosted 2 students BT Young scientist (2019)

Post public seminar discussion lead :You tube: 253 views https://www.youtube.com/watch?v=CCiXcfti4Y4

04032021 Personal view as a female scientist https://apc.ucc.ie/international-womens-day/

2021 Career Journey presentation and discussion to Post Docs APC Microbiome Ireland

2021: Public On line Seminar Can we shape our microbiomes with food and viruses

Jan 2019 -News paper article: Research to lay public: https://www.farminglife.com/business/ps750k-funding-three-agri-food-research-projects-137587

Education and Outreach Committee member APC Microbiome Institute

2019 Cornstore Restaurant Limerick - Food for health

Cornstore restaurant Cork- Food for health 2018 Talks to general public on obesity and Microbiome research

2018 BBC4 Podcast Contributor: The second genome >6Million Downloads https://www.bbc.co.uk/programmes/b09yddx5

2018 Ambassador Aurora Leadership Programme for women

2016 Cork City Gaol - Public Information -Science week 2016

December 2015: Food for health https://www.irishtimes.com/news/science/keep-the-christmas-dinner-safe-from-merry-microbes-1.2457464

2015 Open Science Exhibition CIT

2014 RTE News: Gut microbes and Obesity https://www.rte.ie/news/2014/0506/615513-ucc-bacteria-obesity/

2014: Obesity and Gut bacteria https://www.irishexaminer.com/news/arid-20267601.html

World IBD Day Talk 2014 - talk and discussion with patients CUH

Journal Activities

 JournalRoleTo / From
Frontiers In Nutrition Member of Editorial Board24-APR-21 -
Area Member of Editorial Board17-DEC-20 -
Frontiers In Nutrition Referee24-APR-17 -
Scientific Reports Referee01-JAN-18 -
Journal Of Receptors And Signal Transduction Referee01-JAN-19 -
Bmc Genomics Referee01-JAN-19 -
Future Microbiology Referee01-JAN-19 -
Infection And Immunity Referee01-JAN-16 -
Journal Of Functional Foods Referee01-JUN-16 -
Journal Of Applied Microbiology Referee01-JAN-15 -
Letters In Applied Microbiology Referee01-JAN-15 -
Plos One Referee01-JAN-16 -

Other Activities

 Description

2014 on: +Investigator APC Microbiome Ireland: Funded research,  reporting, interaction and delivery on SFI funded activities within the center.  Discussion with science advisory board and brainstorming sessions thereafter.


Viva Voce roles:
  • Chair for PhD Candidate Thesis Defense (Power & FASS)
  • Internal examiner for UCC PhD Defense (Udayan & Goulding)
  • External Examiner PhD thesis Defense (Bechon, Institute Pasteur, Paris)
  • Supervisor of 6 completed PhD students (+1 ex UCC)


Since 2018: Seminars: 17 invited presentation/seminars,  Posters:18 SAJ Invited speaker*/Keynote**:
  • Irish Mass Spectrometry Society Meeting 2022 Dublin Ireland; 2 posters
  • Probiotics, Prebiotics & New food -Symposium Rome ,Italy 13th September 2021*
  • Microbiology Society UK and Ireland 28th April 2021 ** Online
  • Irish Mass Spectrometry Meeting May 2021 – Dublin, Ireland,1 post doc presentation, 4 posters
  • University College Cork Medical Research and Technology conference November 2020*
  • Science Week Public forum 11th November 2020
  • 8th Microbiome Research and Development Industry Conference Online November 2020**
  • APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance, APC Microbiome Ireland : Post doctoral Talk Dr Anirudh Jaisimha
  • Irish Mass Spectrometry Meeting Dublin, Ireland May 2019* 3 posters
  • Infection and Immunity Microbiome Symposium Bristol April 2019**
  • Cost action Nutredox Conference October Luxemburg 2019*
  • The International Scientific Conference on Probiotics and Prebiotics 2018 Budapest$*
  • Keystone Symposium,  Canada 2018$**
  • World Congress in Gastroenterology Rome, Italy 2018$**
  • 7th International Human Microbiome Conference Kerry Ireland 2018$ – 10 Posters; 3rd prize of 300 posters
  • Falk Bile acids conference Dublin 2018$ -2 posters
  • Wellcome- Cambridge- Microbiome December$ 2018*


Conference Organization:

2022: Annual Irish Mass Spectrometry Society:  meeting May 2022 Organizing Committee

2021: Annual Irish Mass Spectrometry Society Meeting : On line meeting May 2021 Organizing Committee and Session Chair

2021: APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance: APC Microbiome Ireland Community & International Speakers: Committee


2018 Hosted Jinchi Jiang – China –12 months- registered with SEFS Chinese government Scholar

2019 Hosted Dalila Paladino Erasmus student


2017 Hosted Cheri Amana M.Ed placement
Cheri was seeking a host to finish her on line MEd whilst actively teaching.  Her teaching qualification was in the biological sciences. She performed her placement, in my group and successfully reported on the research she performed to gain her qualification

2018 Hosted Erasmus student Silvia Palladinelli – Italy-6 months


2017 on:  Annual attendance to SFI Summit
Exploring strategy, good science, interactive workshops and future initiatives

2017 Hosted Exchange PhD studentDr Roberta Prete – Italy – 18 months


2016 Invited member of the Pharmabiotic Research Institute France – links industry to individuals and determines strategy in Europe for microbiome and gut health

2016 Microbiology Society microbiome research stakeholder Forum, including government ministers,  workshop in Dublin on 15th November 2016 in order to determine strategies in microbiome research for the future.

Teaching Activities

Teaching Interests

I teach within the areas of my research interests: Human,  Cellular and Bacteria Metabolism. Signalling. Food-Microbe-Host interactions. Metabolites. Molecular biology and biochemistry of Metabolism.  Translational Health and Genetics.  Genetics and Gene regulation - human and microbial.

My formal teaching is aligned to different formats: Formal lectures; small group learning (tutorials/workshops/practicals); On line CANVAS recordings and supports (student centered learning tools and assessments (ebooks), simulated practicals (Labster); flipped classrooms; smaller group discussions or breakout rooms. 

Undergraduate modules currently taught (or in past 5 years or longer):

  • BC1024: (10 credit) Introduction to Biomolecules and Metabolic Pathways. 20 contact hours lectures/tutorials; A core module for Dentistry students.  A further 38 hours are delivered by 2 contributors. From AY21-22.  (Module Coordinator) and co-taught with:
  • BC1334: (10 credit) Biochemistry. 24 contact hours lectures/tutorials;A core module for Pharmacy students.  Further 24 hours are delivered by 1 contributor. From AY21-22 (Module Coordinator)
  • BC2024: (5 Credit) Molecular Biology and Gene Regulation in Health & Disease. 11 contact hours to BSc Medical and Health Sciences students Delivered in AY19,20
  • BC3002: (5 credit) Advanced metabolism in health disease and cancer. 24 contact hours. To Biomedical Science (professional degree) students. (Module Coordinator)  co-taught with:
  •  BC4016: (5 credit) Advanced metabolism in health disease and cancer. 24 contact hours. To Biochemistry  students (Module Coordinator) From AY15 to present (AY15+)
  • BC3012:   Literature Project: (Av. 4 students x15 contact hrs).  Core module for Biochemistry III AY16+
  • FM1040: (10 Credits) Foundations of Medicine: Gastrointestinal, Nutritional & Metabolic Biology Core module DEMI. 30 contact hours lectures/tutorials to Direct Entry Medicine professional degree students. It combines 3 disciplines: Anatomy, Physiology, Biochemistry (Module Coordinator)  Taught and co-ordinated from AY15 to AY20-21. Co-taught from AY18 with:
  • MH1040: (10 Credits)Foundations of Medicine: Gastrointestinal, Nutritional & Metabolic Biology Core module for MHBSc I. 30 contact hours lectures/tutorials  (Module Coordinator) AY18-20-21
  • MH1050: (5 Credits) Translational Medicine: Core module for MHBSc I. 4 contact hour lectures. 
  • BC4012: (15 Credit) Research Projects for FYP Biochemistry BSc Year 4: FYP Biochemistry BSc: 160 contact hours (40/student) for project design, supervision, interpretation, presentation. From 2015 –22, 25 students (3-4 /year) engaged for independent laboratory-based research projects (40 contact hours/ student)
  • MH4010: (20 Credits)Translational Medicine: Core module for MHBSc 4 engaged for independent laboratory-based research projects (60 contact hours/ student) Commenced AY21-22: 1 student

Post-graduate modules currently taught: 
  • Director of MRes in Biochemistry and Biosciences (formerly MRes in Biochemistry and Cell Biology) 
  • PG6004: (5 Credits) Scientific Research Planning and Proposals to MRes and PhD students; 4 x 3hr(s) Interactive and assignment based Workshops (12 contact hours). (Module Coordinator) AY21+   


Research led teaching:
My group consists of 12 (9 core) scientists at different stages of development:
  • Current strategic, oversight and direction as main supervisor to 4 PhD students.
  • Currently engaged as main supervisor to 1 MSc (Bioinformatics) .
  • Supporting and co-directing (as co-supervisor) 3 PhD students (40-33%).
  • Directing, shaping and influencing the science and careers of 3 Post doctoral scientists
  • Directing and influencing the work and career of  1 Research Assistant

Other:
Responsible for initiating the School of Biochemistry and Cell Biology Summer Bursary scheme 2017-2019, now passed on to our School Teaching, Learning & Curriculum Committee.

IMPACT: More than 25 students have benefited from training, networking and opportunity in a professional research environment.  Many have now progressed to higher degrees (MSc, PhD) within or outside of UCC

In School roles to influence UG and PG teaching:
  • Chair of the Research Committee, delivering and advocating SEFS and UCC strategic policies and oversight to our School; encouraging awareness and interaction among our and the broader research community; supporting awareness of funding opportunities;  bringing together excellent science and scientists  through strategic planning, oversight (with colleagues) of our School seminar series.  
  • Support and input to shape policy and strategy as a member of Graduate Studies Committee
  • Strategised and developed EDI policy as a member & Working Group Leader of Athena Swan (SAT) Bronze award application 2019+; Currently engaged with the purpose of fulfilling action items supporting our school EDI policy
 SEFS Research & Innovation Committee Member:  Shaping and developing policy,

College Level roles to influence UG & PG Teaching:
  • Member of College Council; Input to strategy at College level
  • SEFS Research & Innovation Committee Member:  Shaping and developing policy, engaging to to implement College and UCC policy and commitments. Piloting new actions for New Connections and in support of strategic plans and objectives.
  • IFUT Committee member: engaging for the common good












Recent Postgraduates

 Graduation YearStudent NameInstitutionDegree TypeThesis Title
2022Keith O'Donoghue NUI (UCC)PHDCo-supervision: Towards a translational understanding of colonic bacteria in Crohn’s disease pathology
2021Shane O'Dwyer MSc UCCMScMain Supervisor: The microbiome in aging
2021David Cussens UCCMScMain Supervisor: C.elegans and the microbiome in aging
2020Jonathan Keane NUI (UCC)PHDMain Supervisor: Changes in the gut microbiota in CRC- cause or consequence
2020Ciara O'Donovan NUI (UCC)PHDCo-Supervisor 33% Elucidating the Microbiome of Irish Athletes
2020Elaine Enright NUI (UCC)PHDMain Supervisor: Gut microbiota mediated bile acid metabolism
2019Sam Walsh UCCMScMain Supervisor: MSc Aging in C.elegans - a microbial perspective
2019Peter Cronin UCCM.Sc. (with distinction)Main Supervisor: MRes Metabolism in CRC -
2019Sarah Louise Long UCCPHD DOCTOR OF PHYSICAL SCIENCESMain Supervisor: Bacterial Bile salt Hydrolase - from selection to impact
2018Ashling Clifford UCCMScMain Supervisor: Cloning and expression of bile altering enzymes
2017Maurice Stanley UCCMScMain Supervisor: MRes: Diet effects in genetic and chemical models of IBD
2015Sarah Conroy UCCMScMain Supervisor: Microbial alterations to host metabolites
2014Stephen Butler UCCMScMain Supervisor
2014Sinead Griffin UCCMScMain Supervisor: In vivo conversion of Bile acids
2013Aoife Redmond UCCMScMain Supervisor
2012Ciara Morgan UCCMScCo Supervisor
2012Catherine Easom UCCPHDCo Supervisor 50%

Current Postgraduate Students

 StudentDegree Type
Saiz Gonzalo Gonzalo Doctoral Degree
Wall Katie Danielle Doctoral Degree
Killian Christina Jane Doctoral Degree

Research Information

Internal Collaborators

 NameInstituteCountry
Dr David Clarke School of MicrobiologyIRELAND
Prof John Cryan UCCIRELAND
Prof Dmitri Papkovsky UCCIRELAND
Prof Jens Walter UCCIRELAND
Dr Dervla O'Malley UCCIRELAND
Dr Marcus Claesson UCC
Dr David Clarke UCC
Dr Silvia Melgar APC Microbiome Institute
Prof Nicole Roy New ZealandNEW ZEALAND

External Collaborators

 NameOrganisation / InstituteCountry
Dr Carel La Roux UCDIRELAND
Prof Paul Cotter Teagasc MooreparkIRELAND
Dr Eibhlis O'Connor University of LimerickIRELAND
Dr Kieran Tuohy FEMS Italy
Dr Julie Lovegrove University of Reading
Dr Orla O'Sullivan Teagasc, MooreparkIRELAND
Dr Irina Tikonova Queens University of BelfastUNITED KINGDOM
Prof. Jun Lin University of KnoxvilleU.S.A.
Dr Prue Pereira Murdochs Childrens Research InstituteAUSTRALIA

Contact details


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School of Biochemistry and Cell Biology

Scoil na Bithcheimice agus na Cillbhitheolaíochta

University College Cork, Western Road, Cork.

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