University College Cork

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4. Susan Joyce

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Biography

Dr Susan Joyce graduated with a B.Sc (joint hons) from NUI Maynooth in Biology and Mathematics and a research PhD in host-microbe interactions. She was awarded a Marie Curie Fellowship to examine cis and trans acting factors affecting mRNA synthesis and microbial gene expression at the Ecole Normal Superieure, Paris which included a stint at the Max Planck Institute, Berlin. Before returning to UCC, Dr Joyce was a postdoctoral scientist at Trinity College Dublin and the Univerity of Bath, UK. Dr Joyces’ main interest is in microbial genetic and biochemical systems that alter eukaryotic host reponse. Susan is currently a Lecturer in the School of Biochemistry and Cell Biology and a funded Investigator in the APC Microbiome Ireland as part of the Spoke 4 Host- Microbe Dialogue.‍

Research Interests

    I am interested in the genetic and biochemical basis of host-microbe interactions, their regulation and outcomes. RESEARCH GROUP OVERVIEW: Gut microbial changes are shaped by many factors, including genetics, diet and environmental factors.  They are recognised as influential in gut development and homeostasis, immune function and local and systemic signalling. There is redundancy for function within the gut microbiome so that “altered function or loss of function” can lead to changes in host signalling favouring different health outcomes.  The lab is interested in microbial functions that can impact health and longevity.  The group has focused on microbial host-metabolite modification systems (for bile acids and more recently fatty acids) and the resulting impact on host signalling processes to influence host processes in health and in disease status. A layered research approach has identified key roles for microbial bile acid metabolism function, strains have been isolated to alter or diversify the bile acid pool and in doing so, local and systemic cell signalling.  Knock on effects include circadian rhythm changes, altered metabolism, immunity, hormonal and developmental adjustments.  A simplified approach (cloning, overexpression, mutational analysis) has assigned specificity of function to different classes and types of bile metabolizing microbial enzymes so as to match microbial activity to disease state deficits.  The use of cell lines and models has revealed impact. We have examined these collective microbial-metabolite-signalling changes over time, in the context of obesity, NAFLD, CVD, CRC in model systems and for their translation and relevance for humans -in the case of CRC and IBDs.  In the lab, we examine gut-specific and systemic impacting microbial functions through a range of different means including molecular genetics, protein expression analysis, targeted and untargeted metabolic analysis of cell, microbial and host material and on the microbiota themselves.                                                                 

Research Grants

	Project	Funding Body	Start Date	End Date	Award
	ERA HDHL-ERA-Net on Biomarkers for Nutrition and Health.	Science Foundation of Ireland	01-JAN-17	31-DEC-19	€249,600.00
	Exploring clues from the changing phenotype of Crohns Disease	Health Research Board	01-OCT-13	30-SEP-16
	Science Foundation Ireland; Infrastructure Category D, Opportunistic Funds; R17475 is the main project	Science Foundation of Ireland	01-JAN-17	30-JUN-19	€30,828.00
	Improved animal husbandry through inhibition of microbial bile salt hydrolase (NAGpro)	Department of Agriculture Fisheries & Forestry (DAFF)	01-MAY-18	30-APR-21	-€301,874.00
	The effect of PepsiCo prebiotic in cases of mild to moderate hypercholesterolemia	Industry	01-SEP-18	28-FEB-19	€95,890.00
	Lily Research Scholarship	Irish Funded Research	01-OCT-17	30-SEP-21	€111,080.00
	Unravelling the metabolic etiology of inflammatory bowel disease (IBD) via lipidome, metabolome and microbiome multivariate analysis	Miscellaneous	05-NOV-18	04-NOV-20	€72,800.00
	APC Microbiome Institute Spoke 4A Host Microbe Dialogue	Science Foundation Ireland	01-JUN-13	31-MAY-19
	Janssen contribution to a targeted project part funded by SFI under 12/RC/2273 (APC3 Research Centre)	SFI Industry	15-FEB-16	01-JUL-17	€144,461.00

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Publications

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Peer Reviewed Journals

	Year	Publication
	(2018)	'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis' Laserna-Mendieta, EJ;Clooney, AG;Carretero-Gomez, JF;Moran, C;Sheehan, D;Nolan, JA;Hill, C;Gahan, CGM;Joyce, SA;Shanahan, F;Claesson, MJ (2018) 'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'. Journal Of Crohns & Colitis, 12 :204-216 [DOI] [Details]
	(2017)	'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism' Golubeva, Anna V.,Joyce, Susan A.,Moloney, Gerard,Burokas, Aurelijus,Sherwin, Eoin,Arboleya, Silvia,Flynn, Ian,Khochanskiy, Dmitry,Moya-Pérez, Angela,Peterson, Veronica,Rea, Kieran,Murphy, Kiera,Makarova, Olga,Buravkov, Sergey,Hyland, Niall P.,Stanton, Catherine,Clarke, Gerard,Gahan, Cormac G. M.,Dinan, Timothy G.,Cryan, John F. (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. EBioMedicine, 24 :166-178   [DOI] [CORA Link] [Details]
	(2016)	'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk' Govindarajan, Kalaimathi,MacSharry, John,Casey, Patrick G.,Shanahan, Fergus,Joyce, Susan A.,Gahan, Cormac G. M. (2016) 'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'. PLoS ONE, 11 (12)   [DOI] [CORA Link] [Details]
	(2016)	'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome' Pereira-Fantini PM, Bines JE, Lapthorne S, Fouhy F, Scurr M, Cotter PD, Gahan CG, Joyce SA. (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Italian Journal of Gastroenterology and Hepatology, [DOI] [Details]
	(2016)	'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health' Joyce SA, Gahan CG. (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Food Science and Technology International, 7 (7):313-333 [DOI] [Details]
	(1994)	'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes' Joyce, Susan A.; Burnell, Ann M.; Powers, Thomas O. (1994) 'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'. Journal of Nematology, 26 (3):260-270   [CORA Link] [Details]
	(2018)	'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein' Enright EF;Govindarajan K;Darrer R;MacSharry J;Joyce SA;Gahan CGM; (2018) 'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'. Molecular Pharmaceutics, [DOI] [Details]
	(2018)	'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism' Enright, E.F. and Griffin, B.T. and Gahan, C.G.M. and Joyce, S.A. (2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'. Pharmacological Research, 133 :170-186   [DOI] [Details]
	(2018)	'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection' Brown, JRM;Flemer, B;Joyce, SA;Zulquernain, A;Sheehan, D;Shanahan, F;O'Toole, PW (2018) 'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'. BMC Gastroenterology, 18 [DOI] [Details]
	(2017)	'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism' Golubeva AV;Joyce SA;Moloney G;Burokas A;Sherwin E;Arboleya S;Flynn I;Khochanskiy D;Moya-Pérez A;Peterson V;Rea K;Murphy K;Makarova O;Buravkov S;Hyland NP;Stanton C;Clarke G;Gahan CGM;Dinan TG;Cryan JF; (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. Ebiomedicine, 24 [DOI] [Details]
	(2017)	'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota' Joyce SA;Gahan CG; (2017) 'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'. Journal of Digestive Diseases, 35 (3) [DOI] [Details]
	(2017)	'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens' Langer, Angela; Moldovan, Adriana; Harmath, Christian; Joyce, Susan A.; Clarke, David J.; Heermann, Ralf (2017) 'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'. Plos One, 12 (4):1-23 [DOI] [CORA Link] [Details]
	(2017)	'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression' Nilaweera, KN;Cabrera-Rubio, R;Speakman, JR;O'Connor, PM;McAuliffe, A;Guinane, CM;Lawton, EM;Crispie, F;Aguilera, M;Stanley, M;Boscaini, S;Joyce, S;Melgar, S;Cryan, JF;Cotter, PD (2017) 'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'. American Journal of Physiology (Endocrinology and Metabolism), 313 :1-11 [DOI] [Details]
	(2017)	'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome' Pereira-Fantini, Prue M.; Lapthorne, Susan; Gahan, Cormac G. M.; Joyce, Susan A.; Charles, Jenny; Fuller, Peter J.; Bines, Julie E. (2017) 'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'. Cellular And Molecular Gastroenterology And Hepatology, 4 (1):65-74 [DOI] [CORA Link] [Details]
	(2017)	'Interactions between gut bacteria and bile in health and disease' Long SL;Gahan CGM;Joyce SA; (2017) 'Interactions between gut bacteria and bile in health and disease'. Molecular aspects of medicine, 56 [DOI] [Details]
	(2016)	'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health' Joyce SA;Gahan CG; (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Annual Review Of Food Science And Technology, Vol 1, 7 [DOI] [Details]
	(2016)	'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome' Pereira-Fantini PM;Bines JE;Lapthorne S;Fouhy F;Scurr M;Cotter PD;Gahan CG;Joyce SA; (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Journal of gastroenterology and hepatology, [DOI] [Details]
	(2016)	'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk' Govindarajan, Kalaimathi; MacSharry, John; Casey, Patrick G.; Shanahan, Fergus; Joyce, Susan A.; Gahan, Cormac G. M. (2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'. Plos One, 11 (1212):e0167319-1-e0167319-13 [DOI] [CORA Link] [Details]
	(2016)	'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome' Enright EF;Gahan CG;Joyce SA;Griffin BT; (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. The Yale journal of biology and medicine, 89 (3) [Details]
	(2016)	'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms' Dowd GC;Bahey-El-Din M;Casey PG;Joyce SA;Hill C;Gahan CG; (2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'. Human Vaccines & Immunotherapeutics, [DOI] [Details]
	(2016)	'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome' Enright, E.F., ,Gahan, C.G.M.,Joyce, S.A.,Griffin, B.T. (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. Yale Journal Of Biology And Medicine, 89 :375-382 [CORA Link] [Details]
	(2016)	'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach' Nolan JA, Kinsella M, Hill C, Joyce SA, Gahan CG. (2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'. Current Microbiology, [DOI] [Details]
	(2016)	'Disease-associated changes in bile acid profiles and links to altered gut microbiota' S.A Joyce and C.G. Gahan (2016) 'Disease-associated changes in bile acid profiles and links to altered gut microbiota'. Digestive Diseases, [DOI] [Details]
	(2014)	'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition' Renier, S;Chagnot, C;Deschamps, J;Caccia, N;Szlavik, J;Joyce, SA;Popowska, M;Hill, C;Knochel, S;Briandet, R;Hebraud, M;Desvaux, M (2014) 'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'. Environmental Microbiology, 16 :1176-1192 [DOI] [Details]
	(2014)	'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut' Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CG (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 (20):7421-7426 [DOI] [Details]
	(2014)	'Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease' Pereira-Fantini PM, Lapthorne S, Joyce SA, Dellios NL, Wilson G, Fouhy F, Thomas SL, Scurr M, Hill C, Gahan CG, Cotter PD, Fuller PJ, Hardikar W, Bines JE (2014) 'Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of hepatology, [DOI] [Details]
	(2014)	'The gut microbiota and the metabolic health of the host' Joyce SA, Gahan CG (2014) 'The gut microbiota and the metabolic health of the host'. Current opinion in gastroenterology, 30 (2):120-127 [DOI] [Details]
	(2013)	'A Mariner Transposon-Based Signature-Tagged Mutagenesis System for the Analysis of Oral Infection by Listeria monocytogenes' Cummins, J,Casey, PG,Joyce, SA,Gahan, CGM (2013) 'A Mariner Transposon-Based Signature-Tagged Mutagenesis System for the Analysis of Oral Infection by Listeria monocytogenes'. Plos One, 8 [DOI] [Details]
	(2012)	'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes' McLaughlin, HP;Xiao, QB;Rea, RB;Pi, HL;Casey, PG;Darby, T;Charbit, A;Sleator, RD;Joyce, SA;Cowart, RE;Hill, C;Klebba, PE;Gahan, CGM (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. Plos One, 7 [DOI] [Details]
	(2012)	'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes' McLaughlin, Heather P.,Xiao, Qiaobin,Rea, Rosemarie B.,Pi, Hualiang,Casey, Pat G.,Darby, Trevor,Charbit, Alain,Sleator, Roy D.,Joyce, Susan A.,Cowart, Richard E.,Hill, Colin,Klebba, Phillip E.,Gahan, Cormac G. M. (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. PLoS ONE, 7 (2)   [DOI] [CORA Link] [Details]
	(2010)	'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment' Jones, Robert T.,Sanchez-Contreras, Maria,Vlisidou, Isabella,Amos, Matthew R.,Yang, Guowei,Muñoz-Berbel, Xavier,Upadhyay, Abhishek,Potter, Ursula J.,Joyce, Susan A.,Ciche, Todd A.,Jenkins, A. Toby A.,Bagby, Stefan,ffrench-Constant, Richard H.,Waterfield, Nicholas R. (2010) 'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'. BMC Microbiology, 10 (1)   [DOI] [CORA Link] [Details]
	(2010)	'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01' Watson, Robert J.,Millichap, Peter,Joyce, Susan A.,Reynolds, Stuart,Clarke, David J. (2010) 'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'. BMC Microbiology, 10 (1)   [DOI] [CORA Link] [Details]
	(2010)	'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens' Easom, Catherine A.; Joyce, Susan A.; Clarke, David J. (2010) 'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'. BMC Microbiology, 10 (1)   [DOI] [CORA Link] [Details]
	(2006)	'Nematode Symbiont for Photorhabdus asymbiotica' Gerrard, John; Joyce, Susan; Clarke, David; ffrench-Constant, Richard; Nimmo, Graeme; Looke, David, F. M.; Feil, Edward; Pearce, Lucy; Waterfield, Nick (2006) 'Nematode Symbiont for Photorhabdus asymbiotica'. Emerging Infectious Disease Journal, 12 (10):1562-1564   [DOI] [CORA Link] [Details]
	(2014)	'.The gut microbiota and the metabolic health of the host' Joyce SA, Gahan CG (2014) '.The gut microbiota and the metabolic health of the host'. Curr Opin Gastroenterolcurr Opin Gastroenterol, 30 (2):120-127 [DOI] [Details]
	(2010)	'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus' Eleftherianos, I;Joyce, S;Ffrench-Constant, RH;Clarke, DJ;Reynolds, SE (2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'. Journal Of Parasitology, 137 :1695-1706 [DOI] [Details]
	(2010)	'TelA Contributes to the Innate Resistance of Listeria monocytogenes to Nisin and Other Cell Wall-Acting Antibiotics' Collins, B;Joyce, S;Hill, C;Cotter, PD;Ross, RP (2010) 'TelA Contributes to the Innate Resistance of Listeria monocytogenes to Nisin and Other Cell Wall-Acting Antibiotics'. Antimicrobial Agents and Chemotherapy, 54 :4658-4663 [DOI] [Details]
	(2014)	'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk' Susan A. Joyce, Fergus Shanahan, Colin Hill, Cormac G.M. (2014) 'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'. Gut microbes, 5 (5):669-674 [DOI] [Details]
	(2014)	'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut' Joyce, S. A.,MacSharry, J.,Casey, P. G.,Kinsella, M.,Murphy, E. F.,Shanahan, F.,Hill, C.,Gahan, C. G. (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Acadamy of Sciences, 111 (20):7421-7426 [Details]
	(2014)	'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease' Pereira-Fantini, Prue M and Lapthorne, Susan and Joyce, Susan A and Dellios, Nicole L and Wilson, Guineva and Fouhy, Fiona and Thomas, Sarah L and Scurr, Michelle and Hill, Colin and Gahan, Cormac GM and others (2014) 'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of Hepatology, [Details]
	(2013)	'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome' PM Pereira-Fantini, S Lapthorne, SA Joyce, NL Dellios, G Wilson, F Fouhy, Colin Hill, Cormac G. M. Gahan, Paul D. Cotter, Peter J. Fuller, Winita Hardikar, Julie E. Bines (2013) 'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'. European Journal of Gastroenterology & Hepatology, 28 :14-15 [Details]
	(2013)	'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection' J. Cummins, P. G. Casey , S. A. Joyce, and C. G.M. Gahan (2013) 'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'. Plos One, 12 (8) [CORA Link] [Details]
	(2013)	'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation' S. Renier, C. Chagnot, J. DeschampS, N. Caccia, J. Szlavik, S. A. Joyce, M. Popowska, C. Hill S. Knochel, R. Briandet, M.Hebart and M. Deesvaux (2013) 'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'. Environmental Microbiology, 16 (4):1176-1192 [DOI] [Details]
	(2012)	'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting' Cronin, M.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J. B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'. Plos One, 7 (11)   [CORA Link] [Details]
	(2011)	'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile' Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
	(2010)	'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus' Eleftherianos, I,Joyce, S,Ffrench-Constant, RH,Clarke, DJ,Reynolds, SE; (2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'. Parasitology, 137 :1695-1706 [DOI] [Details]
	(2010)	'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics' Collins, B. and Joyce, S. and Hill, C. and Cotter, P.D. and Ross, R.P. (2010) 'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'. Antimicrobial agents and chemotherapy, 54 (11):4658-4663 [Details]
	(2009)	'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)' Plichta, K. L., Joyce, S. A., Clarke, D. J., Waterfield, N. and Stock, S. P. ; (2009) 'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'. Journal of Helminthology, 16 :1-12 [Details]
	(2008)	'Bacterial biosynthesis of a multipotent stilbene' Joyce, S. A.,Brachmann, A. O.,Glazer, I.,Lango, L.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2008) 'Bacterial biosynthesis of a multipotent stilbene'. Angew Chem Int Ed Engl, 47 (10):1942-5 [Details]
	(2007)	'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens' Brachmann, A. O.,Joyce, S. A.,Jenke-Kodama, H.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2007) 'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'. Chembiochem, 8 (14):1721-8 [Details]
	(2007)	'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition' Eleftherianos, Ioannis; Boundy, Sam; Joyce, Susan A.; Aslam, Shazia; Marshall, James W.; Cox, Russell J.; Simpson, Thomas J.; Clarke, David J.; ffrench-Constant, Richard H.; Reynolds, Stuart E. (2007) 'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'. Proceedings of The National Acadamy of Sciences, 104 (7):2419-24   [DOI] [Details]
	(2006)	'The regulation of pathogenicity and mutualism in Photorhabdus' Joyce, S. A.,Watson, R. J.,Clarke, D. J.; (2006) 'The regulation of pathogenicity and mutualism in Photorhabdus'. Curr Opin Microbiol, 9 (2):127-32 [Details]
	(2005)	'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis' Watson, R. J.,Joyce, S. A.,Spencer, G. V.,Clarke, D. J.; (2005) 'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'. Mol Microbiol, 56 (3):763-73 [Details]
	(2003)	'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen' ffrench-Constant R, Waterfield N, Daborn P, Joyce S, Bennett H, Au C, Dowling A, Boundy S,Reynolds S, Clarke D. (2003) 'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'. Fems Microbiology Letts, [Details]
	(2003)	'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation' Joyce, S. A.,Clarke, D. J.; (2003) 'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'. Mol Microbiol, 47 (5):1445-57 [Details]
	(2002)	'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli' Joyce SA, Dorman CJ. (2002) 'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'. Molecular Microbiology, 45 (4):1107-1117 [Details]
	(2002)	'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12' Clarke, D. J.,Joyce, S. A.,Toutain, C. M.,Jacq, A.,Holland, I. B.; (2002) 'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'. J Bacteriol, 184 (4):1204-8 [Details]
	(2000)	'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome' Beletskii A, Grigoriev A, Joyce S, Bhagwat AS. (2000) 'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'. Journal of Molecular Biology, 300 :1057-1065 [Details]
	(1999)	'5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation' Joyce, S. A. and Dreyfus M.D (1999) '5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'. Journal of Molecular Biology, 282 :241-254 [Details]
	(1999)	'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo' Lopez PJ, Marchand I, Joyce SA, Dreyfus M (1999) 'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'. Molecular Microbiology, 33 :188-199 [Details]

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Abstract

	Year	Publication
	(2017)	Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. Golubeva, A;Joyce, S;Moloney, G;Burokas, A;Sherwin, A;Arboleya, S;Murphy, K;Hyland, N;Stanton, C;Clarke, G;Gahan, C;Dinan, T;Cryan, J (2017) Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. HOBOKEN: Abstract [Details]

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Professional Activities

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Honours and Awards

	Year	Title	Awarding Body
	2013	APC Person of the Year	Alimentary Pharmabiotic Centre

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Professional Associations

	Association	Function	From / To
	Biochemical Society	Member	/
	Metabolomics Society	Interaction	29-JAN-17 /
	Society for General Microbiology	Member	/

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Patents

	Patent Number	Title	Granted
	11194PC00 EPO	METHODS OF REGULATING WEIGHT GAIN	12-JUN-14

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Committees

	Committee	Function	From / To
	Graduate Committee	School Graduate student and program	2017 /
	Teaching Review Commitee	assessment	/

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Languages

	Language	Reading	Writing	Speaking
	French	Functional	Functional	Functional

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Outreach Activities

	Description
	Education and Outreach Committee member APC Microbiome Institute

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Journal Activities

	Journal	Role	To / From
	Scientific Reports	Referee	-
	Journal Of Receptors And Signal Transduction	Referee	-
	Bmc Genomics	Referee	-
	Future Microbiology	Referee	-
	Infection And Immunity	Referee	-
	Journal Of Functional Foods	Referee	-
	Journal Of Applied Microbiology	Referee	-
	Letters In Applied Microbiology	Referee	-
	Plos One	Referee	-

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Teaching Activities

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Teaching Interests

Microbe -Host interactions Microbial metabolites - Molecular biology and biochemistry of  Metabolism‍

Recent Postgraduates

	Graduation Year	Student Name	Institution	Degree Type	Thesis Title
	2012	Ciara Morgan	UCC	MSc
	2012	Catherine Easom	UCC	PHD
	2013	Aoife Redmond	UCC	MSc
	2014	Sinead Griffin	UCC	MSc
	2014	Stephen Butler	UCC	MSc
	2015	Sarah Conroy	UCC	MSc
	2017	Maurice Stanley	UCC	MSc	Diet effects in genetic and chemical models of IBD
	2018	Ashling Clifford	UCC	MSc	Cloning and expression of bile altering enzymes

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Current Postgraduate Students

	Student	Degree Type
	Keane Jonathan Michael	Doctoral Degree
	Long Sarah-Louise Phyllis	Doctoral Degree
	Killian Christina Jane	Doctoral Degree

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Modules Taught

	Term (ID))	Title	Link	Subject
	2019	Gastrointestinal, Nutritional & Metabolic Bio	MH1040	Gastrointestinal, Nutritional & Metabolic Bio
	2019	Advanced Metabolism in Health, Disease and Cancer	BC3002	Advanced Metabolism in Health, Disease and Cancer
	2019	Advanced Metabolism in Health, Disease and Cancer	BC4016	Advanced Metabolism in Health, Disease and Cancer
	2019	Foundations of Medicine 4 - Gastrointestinal, Nutritional and Metabolic Biology	FM1040	Foundations of Medicine 4 - Gastrointestinal, Nutritional and Metabolic Biology

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Research Information

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Internal Collaborators

	Name	Institute	Country
	Dr David Clarke	School of Microbiology	IRELAND
	Dr Marcus Claesson	UCC
	Dr Cora O'Neill	UCC
	Dr Niall Hyland	UCC
	Dr David Clarke	UCC
	Dr Silvia Melgar	APC Microbiome Institute
	Dr Aileen Houston	CUH/ UCC
	Dr Cormac Gahan	UCC

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External Collaborators

	Name	Organisation / Institute	Country
	Prof. Jun Lin	University of Knoxville	U.S.A.
	Dr Prue Pereira	Murdochs Childrens Research Institute	AUSTRALIA