Biography

Dr Susan Joyce  (H index=47, >8000 citations, 112+ articles) graduated with a B.Sc (joint hons) from Maynooth University in Biology and Mathematics and a research PhD in host-microbe interactions. She was awarded a Marie Curie Fellowship to examine cis and trans acting factors affecting mRNA synthesis and  gene expression at the Ecole Normal Superieure, Paris which included a stint at the Max Planck Institute, Berlin. Before coming to UCC, Dr Joyce was a postdoctoral scientist at the University of Bath, UK (Leverhulme, BBSRC funded) and at Trinity College Dublin. 

Susan Joyce (BSc, PhD, CM, PGCE) is Senior Lecturer at UCC, SEFS and a PI in the UCC Food Institute and an investigator at APC Microbiome Ireland. Her research interests revolve around metabolism and altered human, host and microbial metabolic pathways, with food, that can influence health and disease. She leads a metabolomics focused research group, with expertise in diverse areas of host response through small molecule analysis (MS applications), cellular systems, gene expression and signalling readout, clinical interphase, microbial associations in terms of strain isolation, functional and phenotypic characterization including their metabolites and genetics.  Areas currently under investigation include (1)  metabolomic approach to identify novel biomarkers of microbial  dietary ingredients in fermentation  and (2) metabolomic signatures in deciphering health and ageing (3) specific microbial enzyme inhibition and applications to alter metabolomic signatures towards healthy weight gain.  Susan is a recipient of DAFM and SFI funding. She is a partner in the FP7 project SOPHIA, with a focus on obesity. She was part of the first US/NI/Ireland  i Joint Programming Initiative (JPI) CABALA for health partner in 16 years. She has published over 112 articles including publications in leading journals including Angewande Chemie.  PNAS, GUT, J Hepatol, Cell and Nature Comms. She regularly serves as a reviewer for international and national grant awards and for international journals and she is serving as an associate editor Frontiers in Nutrition and Editorial Board of Liver Research.

She is actively involved in biochemistry undergraduate and postgraduate teaching and research, and has deliveed a range of lectures in advanced metabolism at all BSc levels and to accredited professional degrees including Pharmacy, Dentistry,  Medical and medicine and health students. She host a series of postgraduate interactive workshops with postgraduate students on strategy (next steps), scientific writing (the blank page) and approaches to award and grant writing.  She was (student) nominated for the Presidents Prize for Excellence in Teaching (Dec 2022) and she was Research Team nominated and awarded an Irish Research Council Ally award for mentorship (Dec 2021).  She is Director of MRes in Biochemistry and Cell Biology from 2021- 2025, which, post stakeholder engagement, is now remodeled and recommenced as MRes in Biochemistry and Biosciences, in AY2021, it was a finalist for OPEX (operational excellence) awards at third level.  She served as  Chair of her School Research committee, Vice Chair of the Research Committee College of SEFS (2020-2024), Vice-Chair of the Irish Mass Spectrometry Society (IMSS) to 2020-2024.  Her full publication list is available at: http://orcid.org/0000-0003-4771-3123 and at https://scholar.google.com/citations?hl=en&user=6KpVtU0AAAAJ




Research Interests

My research focuses on elucidating the genetic and biochemical basis of host-microbe interactions, their regulation and outcomes.

RESEARCH GROUP OVERVIEW: The Gut and its microbiota ( in health and disease) is shaped by diet, environment and gut microbial changes as well as by host genetics.  The influence of these combined factors contributes to processes including gut development and homeostasis, immune function and local and systemic signalling in defining health outcomes.

My group dissects how these different and combined factors can impact health, disease and longevity. The group has focused on microbial host-metabolite and dietary modification that impact the host  (including drug uptake, adiposity, circadian rhythm, immune functions) with a particular emphasis on signalling processes to identity key areas for therapeutic approaches.  We apply targeted and untargeted metabolomic approaches, animal models, cell systems and bacterial molecular and cellular biology to address our questions.

We investigate and pursue:
  • Mechanistic understanding of food enrichment for specific classes of microbes and their fitness to function
  • Understanding of the alternative lifestyles of microbes in the gut, what makes a commensal become a pathobiont?
  • How microbial metabolism of diet and host produced factors reprogramme cell and metabolic processes
  • The interactions between food-microbes and their hosts towards disease and in maintaining health
  • Simply defining health, in the context of microbial functions and modification of metabolites to influence cell signalling processes
  • Drugs and bugs - re-potentiating mechanisms



Research Grants

  Project Funding
Body 		Start Date End Date Award
Determining the biotherapeutic potential of missing Lachnospiraceae in inflammatory bowel diseases Science Foundation Ireland 02-JAN-23 01-JAN-27 €475,000.00
Science Foundation of Ireland 01-APR-24 28-MAR-28 €143,000.00
Fitbiota: “Examining the emergence of a fit gut microbiome in young adults and the potential impacts on gut health" Teagasc 01-APR-24 28-MAR-28 €110,000.00
Food and fermentation - metabolic and immune systems influences. Foreign Industry 01-JAN-23 31-MAR-25 €147,780.00
Metabolites in nutritional Signaling Industry Sponsor 02-JAN-23 01-JAN-25 €120,000.00
BSH inhibition for animal husbandry optimization (BIAHOP) Irish Research Council 01-SEP-22 06-NOV-24 €99,513.00
OMIT Horizon 2020 01-NOV-21 31-OCT-23 €196,591.00
HEA COVID Support Call 4 HEACOVID19 01-OCT-23 31-JAN-24 €6,167.00
HEA COVID Support Call 4 HEACOVID19 01-OCT-23 31-MAR-24 €6,168.00
HEACOVID19 01-APR-21 31-JUL-21 €5,933.00
HEACOVID19 01-APR-21 31-JUL-21 €16,875.00
HEACOVID19 01-APR-21 31-AUG-21 €11,298.00
SOPHIA “Stratification of Obese Phenotypes to Optimize Future Obesity Therapy” Horizon 2020 01-JUN-20 31-MAY-25 €20,000.00
HEACOVID19 01-DEC-20 30-APR-21 €17,117.00
Redressing the Impact of Industrialization on Gut Microbiome Composition and Function (Microbe Restore) Science Foundation of Ireland 01-NOV-20 31-OCT-25 €265,000.00
APC4 12/RC/2273_P2 Spoke 4 Microbe Dialogue: Aim 4.2b Science Foundation of Ireland 01-JUN-19 31-DEC-25 €451,743.00
APC4_12/RC/2273_P2 - TP Pepsico - Susan Joyce SFI Industry 01-JUL-19 31-AUG-21 €155,865.00
SFI 12-RC-2273_P2 IND Pepsico TP"Fermented Oat Dairy Project" Dr Susan Joyce [X] SFI Industry 01-JUN-19 31-MAR-20 €61,113.00
An Analysis of the Role of Eraly Gut Colonizers, E-coli and Bacteroides, In Bile Acid Metabolism. Irish Research Council 01-SEP-19 31-AUG-22 €105,333.00
Improved animal husbandry through inhibition of microbial bile salt hydrolase (NAGpro) Department of Agriculture Fisheries & Forestry (DAFF) 01-NOV-18 31-AUG-22 €301,874.00
Unravelling the metabolic etiology of inflammatory bowel disease (IBD) via lipidome, metabolome and microbiome multivariate analysis Miscellaneous 05-NOV-18 31-OCT-21 €72,800.00
Fermented Oat Dairy Product SFI Industry 01-NOV-18 31-MAY-19 €11,037.00
The effect of PepsiCo prebiotic in cases of mild to moderate hypercholesterolemia Industry 01-SEP-18 31-MAY-19 €95,890.00
Lily Research Scholarship Irish Funded Research 01-OCT-17 10-JUN-22 €111,080.00
ERA HDHL-ERA-Net on Biomarkers for Nutrition and Health. Science Foundation of Ireland 01-JAN-17 31-DEC-20 €249,600.00
Science Foundation Ireland; Infrastructure Category D, Opportunistic Funds; R17475 is the main project Science Foundation of Ireland 01-JAN-17 30-JUN-19 €30,828.00
The microbiome in the context of IBD 01-OCT-16 01-MAR-22 €93,000.00
Janssen contribution to a targeted project part funded by SFI under 12/RC/2273 (APC3 Research Centre) SFI Industry 15-FEB-16 01-JUL-17 €144,461.00
Microbiota and Colorectal Cancer -Cause or consequence 01-OCT-15 01-OCT-19 €93,000.00
Bacterial Bile Salt hydrolase: from selection to impact on host metabolism and microbiota 01-OCT-15 30-SEP-19 €151,000.00
APC Microbiome Institute Spoke 4A Host Microbe Dialogue Science Foundation Ireland 01-JUN-13 31-MAY-19
Exploring clues from the changing phenotype of Crohns Disease Health Research Board 01-OCT-13 30-SEP-16

Contract Researchers

  Researcher Name Project Role Funding Body
2018-2023 Dr Eileen Ryan 2 sequential Projects: IBD-ome APEX Fellow to 2021 & MCRA Fellow "OMIT" from 2021 Postdoctoral Researcher European Commission
Dr Karina Quilter Sept 2024 to current APC Research Assistant Science Foundation Ireland
2019- current Dr Karim Hayoun 2 sequential projects: DAFM- NAG Pro & IRC commencing 2022 Academic Sponsor Department of Agriculture, Fisheries & Food (DAFF)
2021- 2021: 2022-2023 Dr Amed Kabir Industry - 9 month project; 6 month Project Academic Sponsor Industry Sponsor
Mar -August 2022- Dr Sourav Roy Choudhury APC 4 Theme 4 Academic Sponsor Science Foundation Ireland
2021-Dec 2022 Mr Darragh Mattimoe 2 sequential projects: Industry & APC theme 4 Academic Sponsor Industry Sponsor
2015-2021 Mr Alvaro Lopez Gallardo APC 3 Spoke 4 Academic Sponsor
2019-2021 Dr Anirudh Jaisimha 2 sequential Projects: APC theme 4 & Cabala for health JPI: SFI-EU Postdoctoral Researcher Science Foundation Ireland

Abstract

  Year Publication
(2017) Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism.
Golubeva, A;Joyce, S;Moloney, G;Burokas, A;Sherwin, A;Arboleya, S;Murphy, K;Hyland, N;Stanton, C;Clarke, G;Gahan, C;Dinan, T;Cryan, J (2017) Microbiota-related changes in bile acid and serotonin metabolism are associated with gastrointestinal dysfunction in a mouse model of autism. HOBOKEN: Abstract [Details]
(2015) Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model.
Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fouhy, F;Scurr, M;Cotter, PD;Gahan, CG;Bines, JE (2015) Early and persistent disturbance of the bile acid-microbial axis in a piglet short bowel syndrome model. HOBOKEN: Abstract [Details]
(2015) Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease.
Pereira-Fantini, PM;Lapthorne, S;Joyce, SA;Fuller, PJ;Bines, JE (2015) Activation of nuclear bile acid receptor FXR alters bile acid metabolism but exacerbates liver damage in a piglet model of SBS-associated liver disease. HOBOKEN: Abstract [Details]

Other Journals

  Year Publication
(2022) 'Lipidomic analysis reveals differences in Bacteroides species driven largely by plasmalogens, glycerophosphoinositols and certain sphingolipids'
Ryan E.; Clarke, D.J.; Joyce S.A. (2022) 'Lipidomic analysis reveals differences in Bacteroides species driven largely by plasmalogens, glycerophosphoinositols and certain sphingolipids' Biorxiv : The Preprint Server For Biology, 1 (1) :1-12. [DOI] [Details]
(2022) 'Rational selection and Characterisation of bile acid (BA) metabolising species of infant origin'
Long S.L and Joyce SA (2022) 'Rational selection and Characterisation of bile acid (BA) metabolising species of infant origin' Biorxiv : The Preprint Server For Biology, 1 (1) :1-12. [ Publisher's Version] [DOI] [Details]

Encyclopedia Entries

  Year Publication
Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression.
Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression. . Encyclopedia Entries. [DOI] [Details]

Peer Reviewed Journals

  Year Publication
(2023) 'Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules'
Eileen Ryan; Susan A. Joyce; David J. Clarke (2023) 'Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules'. Microbiology Journal, [Details]
(2023) 'Characterisation of the mechanism of Bile Salt Hydrolase substrate specificity by experimental and computational analyses'
D.S. Karlov, S.L. Long, X. Zeng, F. Xu, K. Lal, L.Cao, K. Hayoun, J Lin*, S.A. Joyce,*and I.G. Tikhonova* (2023) 'Characterisation of the mechanism of Bile Salt Hydrolase substrate specificity by experimental and computational analyses'. Composite Structures, 31 (31):1-10 [ Publisher's Version] [DOI] [Details]
(2023) 'Lipidomic analysis reveals differences in Bacteroides species driven largely by plasmalogens, glycerophosphoinositols and certain sphingolipids'
Ryan, E.; Gonzalez Pastor, B.; Gethings, L.A.; Clarke, D.J.; Joyce, S.A. (2023) 'Lipidomic analysis reveals differences in Bacteroides species driven largely by plasmalogens, glycerophosphoinositols and certain sphingolipids'. Metabolites, 13 (13):360-400 [ Publisher's Version] [Details]
(2023) 'Ultra-Endurance Triathlon Competition Shifts Fecal Metabolome Independent of Changes to Microbiome Composition'
Gregory Grosicki, Jamie Pugh, Laura Wosinska, Karina Quilter, Darragh Mattimoe, Jacob Allen, Susan Joyce, Orla O'Sullivan, and Graeme Close (2023) 'Ultra-Endurance Triathlon Competition Shifts Fecal Metabolome Independent of Changes to Microbiome Composition'. American Journal of Physiology - Cell Physiology, [Details]
(2023) 'Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial'
Pushpass, PG., Alzoufairi, S., Mancini, A., Quilter, K., Fava, F., Delaiti, S., Vrhovsek, U., Christensen, C., Joyce,SA.,Tuohy, KM., Jackson, K., & J.A. Lovegrove, (2023) 'Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial'. American Journal of Clinical Nutrition, 117 (2):252-265 [ Publisher's Version] [DOI] [Details]
(2023) 'Dietary-Induced Bacterial Metabolites Reduce Inflammation and Inflammation-Associated Cancer via Vitamin D Pathway'
O’Mahony, C.; Clooney, A.; Clarke, S.F.; Aguilera, M.; Gavin, A.; Simnica, D.; Ahern, M.; Fanning, A.; Stanley, M.; Rubio, R.C.; Patterson, E.; Marques, T.; Wall, R.; Houston, A.; Mahmoud, A.; Bennett, M.W.; Stanton, C.; Claesson, M.J.; Cotter, P.D.; Shanahan, F.; Joyce, S.A.; Melgar, S. (2023) 'Dietary-Induced Bacterial Metabolites Reduce Inflammation and Inflammation-Associated Cancer via Vitamin D Pathway'. International Journal of Molecular Sciences, 24 :1864-1894 [ Publisher's Version] [DOI] [Details]
(2022) 'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication'
Joyce, Susan A.;O'Malley, Dervla (2022) 'Bile acids, bioactive signalling molecules in interoceptive gut-to-brain communication'. Journal of Physiology-London, [DOI] [Full Text] [Details]
(2022) 'Heterosubstituted Derivatives of PtPFPP for O2 Sensing and Cell Analysis: Structure–Activity Relationships'
Chiara Zanetti, Rafael Di Lazaro Gaspar, Alexander V. Zhdanov, Nuala M. Maguire, Susan A. Joyce, SA.,Collins, SG., Maguire, AR and DB Papkovsky (2022) 'Heterosubstituted Derivatives of PtPFPP for O2 Sensing and Cell Analysis: Structure–Activity Relationships'. Bioconjugate Chemistry, 33 (11):2121-2161 [ Publisher's Version] [DOI] [Details]
(2022) 'Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial'
Pushpass, RAG, Alzoufairi, S., Mancini, A., Quilter, K., Fava, F., Delaiti, S., Vrhovsek, U., Christensen, C., Joyce, SA., Tuohy, KM., Jackson, KG., Lovegrove, JA. (2022) 'Chronic consumption of probiotics, oats, and apples has differential effects on postprandial bile acid profile and cardiometabolic disease risk markers compared with an isocaloric control (cornflakes): a randomized trial'. The American Journal of Clinical Nutrition, [ Publisher's Version] [DOI] [Details]
(2022) 'Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints'
Keane, J.M., Walsh, C.J., Cronin, P. et al (2022) 'Investigation of the gut microbiome, bile acid composition and host immunoinflammatory response in a model of azoxymethane-induced colon cancer at discrete timepoints'. Br J Cancerbr J Cancer, 128 :526-536 [ Publisher's Version] [DOI] [Details]
(2021) 'Dietary Fibre Modulates the Gut Microbiota'
Cronin P;Joyce SA;O'Toole PW;O'Connor EM; (2021) 'Dietary Fibre Modulates the Gut Microbiota'. Nutrients, 13 (5) [DOI] [Details]
(2021) 'Concentrations of Fecal Bile Acids in Participants with Functional Gut Disorders and Healthy Controls'
James SC;Fraser K;Young W;Heenan PE;Gearry RB;Keenan JI;Talley NJ;Joyce SA;McNabb WC;Roy NC; (2021) 'Concentrations of Fecal Bile Acids in Participants with Functional Gut Disorders and Healthy Controls'. Metabolites, 11 (9) [DOI] [Details]
(2021) 'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli'
Duysburgh C;Van den Abbeele P;Kamil A;Fleige L;De Chavez PJ;Chu Y;Barton W;O'Sullivan O;Cotter PD;Quilter K;Joyce SA;Murphy M;DunnGalvin G;Dinan TG;Marzorati M; (2021) 'In vitro-in vivo Validation of Stimulatory Effect of Oat Ingredients on Lactobacilli'. Pathogens (Basel, Switzerland), 10 (2) [DOI] [Details]
(2020) 'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions'
Enright E.F.;Joyce S.A.;Gahan C.G.M.;Taylor L.S. (2020) 'Impact of phospholipid digests and bile acid pool variations on the crystallization of atazanavir from supersaturated solutions'. European Journal Of Pharmaceutics And Biopharmaceutics, 153 :68-83 [DOI] [Details]
(2020) 'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities'
Prete, Roberta; Long, Sarah L.; Joyce, Susan A.; Corsetti, Aldo (2020) 'Genotypic and phenotypic characterization of food-associated Lactobacillus plantarum isolates for potential probiotic activities'. Fems Microbiology Letters, [DOI] [Full Text] [Details]
(2020) 'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease'
Ryan F.J.;Ahern A.M.;Fitzgerald R.S.;Laserna-Mendieta E.J.;Power E.M.;Clooney A.G.;O’Donoghue K.W.;McMurdie P.J.;Iwai S.;Crits-Christoph A.;Sheehan D.;Moran C.;Flemer B.;Zomer A.L.;Fanning A.;O’Callaghan J.;Walton J.;Temko A.;Stack W.;Jackson L.;Joyce S.A.;Melgar S.;DeSantis T.Z.;Bell J.T.;Shanahan F.;Claesson M.J. (2020) 'Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease'. Nature Communications, 11 (1) [DOI] [Full Text] [Details]
(2020) 'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system'
Geng W.;Long S.L.;Chang Y.J.;Saxton A.M.;Joyce S.A.;Lin J. (2020) 'Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
(2020) 'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin'
Prete R.;Long S.;Gallardo A.;Gahan C.;Corsetti A.;Joyce S. (2020) 'Beneficial bile acid metabolism from Lactobacillus plantarum of food origin'. Scientific Reports, 10 (1) [DOI] [Full Text] [Details]
(2019) 'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection'
Mullish B.;McDonald J.;Pechlivanis A.;Allegretti J.;Kao D.;Barker G.;Kapila D.;Petrof E.;Joyce S.;Gahan C.;Glegola-Madejska I.;Williams H.;Holmes E.;Clarke T.;Thursz M.;Marchesi J. (2019) 'Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection'. Gut, [DOI] [Full Text] [Details]
(2019) 'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome'
O’Donovan S.;Crowley E.;Brown J.;O’Sullivan O.;O’Leary O.;Timmons S.;Nolan Y.;Clarke D.;Hyland N.;Joyce S.;Sullivan A.;O'Neill C. (2019) 'Nigral overexpression of a-synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome'. Neurogastroenterology and Motility, [DOI] [Details]
(2019) 'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome'
Susan A. Joyce, Alison Kamil, Lisa Fleige and Cormac G. M. Gahan (2019) 'The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome'. Frontiers in Nutrition, 6 [DOI] [Details]
(2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'
Ryan, PM;Stolte, EH;London, LEE;Wells, JM;Long, SL;Joyce, SA;Gahan, CGM;Fitzgerald, GF;Ross, RP;Caplice, NM;Stanton, C (2019) 'Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe'. BMC Microbiology, 19 [DOI] [Details]
(2018) 'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'
Enright EF;Govindarajan K;Darrer R;MacSharry J;Joyce SA;Gahan CGM; (2018) 'Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein'. Molecular Pharmaceutics, [DOI] [Details]
(2018) 'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'
Laserna-Mendieta, EJ;Clooney, AG;Carretero-Gomez, JF;Moran, C;Sheehan, D;Nolan, JA;Hill, C;Gahan, CGM;Joyce, SA;Shanahan, F;Claesson, MJ (2018) 'Determinants of Reduced Genetic Capacity for Butyrate Synthesis by the Gut Microbiome in Crohn's Disease and Ulcerative Colitis'. Journal Of Crohns & Colitis, 12 :204-216 [DOI] [Details]
(2018) 'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'
Brown, JRM;Flemer, B;Joyce, SA;Zulquernain, A;Sheehan, D;Shanahan, F;O'Toole, PW (2018) 'Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection'. BMC Gastroenterology, 18 [DOI] [Details]
(2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'
Enright, E.F. and Griffin, B.T. and Gahan, C.G.M. and Joyce, S.A. (2018) 'Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism'. Pharmacological Research, 133 :170-186 [ Publisher's Version] [DOI] [Details]
(2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'
Golubeva AV;Joyce SA;Moloney G;Burokas A;Sherwin E;Arboleya S;Flynn I;Khochanskiy D;Moya-Pérez A;Peterson V;Rea K;Murphy K;Makarova O;Buravkov S;Hyland NP;Stanton C;Clarke G;Gahan CGM;Dinan TG;Cryan JF; (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. Ebiomedicine, 24 [DOI] [Details]
(2017) 'Pathophysiologic gut hormone and bile acid signalling after oesophagectomy: implications for appetite, postprandial hypoglycaemia and nutritional status in survivorship'
Elliott, J.A., Murphy, C.F., Docherty, N.G., Doyle, S.L., Gallardo, A.L., Gahan, C., Joyce, S., Ravi, N., Reynolds, J.V. and le Roux, C.W. (2017) 'Pathophysiologic gut hormone and bile acid signalling after oesophagectomy: implications for appetite, postprandial hypoglycaemia and nutritional status in survivorship'. International Journal Of Surgery, s (S91):91-91 [Details]
(2017) 'Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., 2017. Mechansims Underpinning Successful Faecal Microbiota Transplantation (FMT) for Recurrent Clostridium Difficile Infection'
Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., (2017) 'Sheehan, D., Brown, J., Flemer, B., Zulquernain, S.A., Gahan, C.G., Joyce, S., Shanahan, F. and O'Toole, P.W., 2017. Mechansims Underpinning Successful Faecal Microbiota Transplantation (FMT) for Recurrent Clostridium Difficile Infection'. BMC Gastroenterology, 152 (5) [Details]
(2017) 'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'
Langer, Angela; Moldovan, Adriana; Harmath, Christian; Joyce, Susan A.; Clarke, David J.; Heermann, Ralf (2017) 'HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens'. Plos One, 12 (4):1-23 [DOI] [Full Text] [Details]
(2017) 'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'
Joyce SA;Gahan CG; (2017) 'Disease-Associated Changes in Bile Acid Profiles and Links to Altered Gut Microbiota'. Journal of Digestive Diseases, 35 (3) [DOI] [Details]
(2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'
Golubeva, Anna V.,Joyce, Susan A.,Moloney, Gerard,Burokas, Aurelijus,Sherwin, Eoin,Arboleya, Silvia,Flynn, Ian,Khochanskiy, Dmitry,Moya-Pérez, Angela,Peterson, Veronica,Rea, Kieran,Murphy, Kiera,Makarova, Olga,Buravkov, Sergey,Hyland, Niall P.,Stanton, Catherine,Clarke, Gerard,Gahan, Cormac G. M.,Dinan, Timothy G.,Cryan, John F. (2017) 'Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism'. EBioMedicine, 24 :166-178 [ Publisher's Version] [DOI] [Full Text] [Details]
(2017) 'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'
Pereira-Fantini, Prue M.; Lapthorne, Susan; Gahan, Cormac G. M.; Joyce, Susan A.; Charles, Jenny; Fuller, Peter J.; Bines, Julie E. (2017) 'Farnesoid X Receptor Agonist Treatment Alters Bile Acid Metabolism but Exacerbates Liver Damage in a Piglet Model of Short-Bowel Syndrome'. Cellular And Molecular Gastroenterology And Hepatology, 4 (1):65-74 [DOI] [Full Text] [Details]
(2017) 'Interactions between gut bacteria and bile in health and disease'
Long SL;Gahan CGM;Joyce SA; (2017) 'Interactions between gut bacteria and bile in health and disease'. Molecular aspects of medicine, 56 [DOI] [Details]
(2017) 'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'
Nilaweera, KN;Cabrera-Rubio, R;Speakman, JR;O'Connor, PM;McAuliffe, A;Guinane, CM;Lawton, EM;Crispie, F;Aguilera, M;Stanley, M;Boscaini, S;Joyce, S;Melgar, S;Cryan, JF;Cotter, PD (2017) 'Whey protein effects on energy balance link the intestinal mechanisms of energy absorption with adiposity and hypothalamic neuropeptide gene expression'. American Journal of Physiology (Endocrinology and Metabolism), 313 :1-11 [DOI] [Details]
(2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'
Dowd GC;Bahey-El-Din M;Casey PG;Joyce SA;Hill C;Gahan CG; (2016) 'Listeria monocytogenes mutants defective in gallbladder replication represent safety-enhanced vaccine delivery platforms'. Human Vaccines & Immunotherapeutics, [DOI] [Details]
(2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'
Enright EF;Gahan CG;Joyce SA;Griffin BT; (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. The Yale journal of biology and medicine, 89 (3) [Details]
(2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'
Joyce SA, Gahan CG. (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Food Science and Technology International, 7 (7):313-333 [DOI] [Details]
(2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'
Joyce SA;Gahan CG; (2016) 'Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health'. Annual Review Of Food Science And Technology, Vol 1, 7 [DOI] [Details]
(2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'
Govindarajan, Kalaimathi; MacSharry, John; Casey, Patrick G.; Shanahan, Fergus; Joyce, Susan A.; Gahan, Cormac G. M. (2016) 'Unconjugated bile acids influence expression of circadian genes: a potential mechanism for microbe-host crosstalk'. Plos One, 11 (1212):e0167319-1-e0167319-13 [DOI] [Full Text] [Details]
(2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'
Pereira-Fantini PM, Bines JE, Lapthorne S, Fouhy F, Scurr M, Cotter PD, Gahan CG, Joyce SA. (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Italian Journal of Gastroenterology and Hepatology, [DOI] [Details]
(2016) 'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'
Govindarajan, Kalaimathi,MacSharry, John,Casey, Patrick G.,Shanahan, Fergus,Joyce, Susan A.,Gahan, Cormac G. M. (2016) 'Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk'. PLoS ONE, 11 (12) [ Publisher's Version] [DOI] [Full Text] [Details]
(2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'
Nolan JA, Kinsella M, Hill C, Joyce SA, Gahan CG. (2016) 'Analysis of the Impact of Rosuvastatin on Bacterial Mevalonate Production Using a UPLC-Mass Spectrometry Approach'. Current Microbiology, [DOI] [Details]
(2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'
Pereira-Fantini PM;Bines JE;Lapthorne S;Fouhy F;Scurr M;Cotter PD;Gahan CG;Joyce SA; (2016) 'Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome'. Journal of gastroenterology and hepatology, [DOI] [Details]
(2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'
Enright, E.F., ,Gahan, C.G.M.,Joyce, S.A.,Griffin, B.T. (2016) 'The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome'. Yale Journal Of Biology And Medicine, 89 :375-382 [Full Text] [Details]
(2016) 'Disease-associated changes in bile acid profiles and links to altered gut microbiota'
S.A Joyce and C.G. Gahan (2016) 'Disease-associated changes in bile acid profiles and links to altered gut microbiota'. Digestive Diseases, [DOI] [Details]
(2014) 'The gut microbiota and the metabolic health of the host'
Joyce SA, Gahan CG (2014) 'The gut microbiota and the metabolic health of the host'. Current opinion in gastroenterology, 30 (2):120-127 [DOI] [Details]
(2014) 'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'
Renier, S;Chagnot, C;Deschamps, J;Caccia, N;Szlavik, J;Joyce, SA;Popowska, M;Hill, C;Knochel, S;Briandet, R;Hebraud, M;Desvaux, M (2014) 'Inactivation of the SecA2 protein export pathway in Listeria monocytogenes promotes cell aggregation, impacts biofilm architecture and induces biofilm formation in environmental condition'. Environmental Microbiology, 16 :1176-1192 [DOI] [Details]
(2014) 'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'
Pereira-Fantini, PM,Lapthorne, S,Joyce, SA,Dellios, NL,Wilson, G,Fouhy, F,Thomas, SL,Scurr, M,Hill, C,Gahan, CGM,Cotter, PD,Fuller, PJ,Hardikar, W,Bines, JE (2014) 'Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease'. Journal of hepatology, 61 :1115-1125 [DOI] [Details]
(2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'
Joyce SA, MacSharry J, Casey PG, Kinsella M, Murphy EF, Shanahan F, Hill C, Gahan CG (2014) 'Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut'. Proceedings of The National Academy of Sciences of The United States of America, 111 (20):7421-7426 [DOI] [Details]
(2014) 'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'
Susan A. Joyce, Fergus Shanahan, Colin Hill, Cormac G.M. (2014) 'Role of bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk'. Gut microbes, 5 (5):669-674 [DOI] [Details]
(2013) 'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'
S. Renier, C. Chagnot, J. DeschampS, N. Caccia, J. Szlavik, S. A. Joyce, M. Popowska, C. Hill S. Knochel, R. Briandet, M.Hebart and M. Deesvaux (2013) 'Inactivation of the SecA2 Protein 1 Export Pathway in Listeria monocytogenes Promotes Cell Aggregation, Impacts Biofilm Architecture and Induces Biofilm Formation'. Environmental Microbiology, 16 (4):1176-1192 [DOI] [Details]
(2013) 'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'
J. Cummins, P. G. Casey , S. A. Joyce, and C. G.M. Gahan (2013) 'A mariner transposon-based signature-tagged mutagenesis system for analysis of the gastrointestinal phase of Listeria monocytogenes infection'. Plos One, 12 (8) [Full Text] [Details]
(2013) 'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'
PM Pereira-Fantini, S Lapthorne, SA Joyce, NL Dellios, G Wilson, F Fouhy, Colin Hill, Cormac G. M. Gahan, Paul D. Cotter, Peter J. Fuller, Winita Hardikar, Julie E. Bines (2013) 'Bines Disturbed bile acid metabolism as a cause of intestinal failure-associated liver disease in a piglet model of short bowel syndrome'. European Journal of Gastroenterology & Hepatology, 28 :14-15 [Details]
(2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'
McLaughlin, Heather P.,Xiao, Qiaobin,Rea, Rosemarie B.,Pi, Hualiang,Casey, Pat G.,Darby, Trevor,Charbit, Alain,Sleator, Roy D.,Joyce, Susan A.,Cowart, Richard E.,Hill, Colin,Klebba, Phillip E.,Gahan, Cormac G. M. (2012) 'A Putative P-Type ATPase Required for Virulence and Resistance to Haem Toxicity in Listeria monocytogenes'. PLoS ONE, 7 (2) [ Publisher's Version] [DOI] [Full Text] [Details]
(2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'
Cronin, M.,Akin, A. R.,Collins, S. A.,Meganck, J.,Kim, J. B.,Baban, C. K.,Joyce, S. A.,van Dam, G. M.,Zhang, N.,van Sinderen, D.,O'Sullivan, G. C.,Kasahara, N.,Gahan, C. G.,Francis, K. P.,Tangney, M. (2012) 'High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting'. Plos One, 7 (11) [ Publisher's Version] [Full Text] [Details]
(2011) 'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens'
Joyce S.;Lango L.;Clarke D. (2011) 'The Regulation of Secondary Metabolism and Mutualism in the Insect Pathogenic Bacterium Photorhabdus luminescens'. Advances In Applied Microbiology, 76 :1-25 [DOI] [Details]
(2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'
Dowd, G.C. and Joyce, S.A. and Hill, C. and Gahan, C.G.M. (2011) 'Investigation of the Mechanisms by Which Listeria monocytogenes Grows in Porcine Gallbladder Bile'. Infection and immunity, 79 (1) [Details]
(2010) 'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'
Collins, B. and Joyce, S. and Hill, C. and Cotter, P.D. and Ross, R.P. (2010) 'TelA contributes to the innate resistance of Listeria monocytogenes to nisin and other cell wall-acting antibiotics'. Antimicrobial agents and chemotherapy, 54 (11):4658-4663 [Details]
(2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'
Eleftherianos, I,Joyce, S,Ffrench-Constant, RH,Clarke, DJ,Reynolds, SE; (2010) 'Probing the tri-trophic interaction between insects, nematodes and Photorhabdus'. Parasitology, 137 :1695-1706 [DOI] [Details]
(2010) 'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'
Watson, Robert J.,Millichap, Peter,Joyce, Susan A.,Reynolds, Stuart,Clarke, David J. (2010) 'The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01'. BMC Microbiology, 10 (1) [ Publisher's Version] [DOI] [Full Text] [Details]
(2010) 'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'
Easom, Catherine A.; Joyce, Susan A.; Clarke, David J. (2010) 'Identification of genes involved in the mutualistic colonization of the nematode Heterorhabditis bacteriophora by the bacterium Photorhabdus luminescens'. BMC Microbiology, 10 (1) [ Publisher's Version] [DOI] [Full Text] [Details]
(2010) 'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'
Jones, Robert T.,Sanchez-Contreras, Maria,Vlisidou, Isabella,Amos, Matthew R.,Yang, Guowei,Muñoz-Berbel, Xavier,Upadhyay, Abhishek,Potter, Ursula J.,Joyce, Susan A.,Ciche, Todd A.,Jenkins, A. Toby A.,Bagby, Stefan,ffrench-Constant, Richard H.,Waterfield, Nicholas R. (2010) 'Photorhabdus adhesion modification protein (Pam) binds extracellular polysaccharide and alters bacterial attachment'. BMC Microbiology, 10 (1) [ Publisher's Version] [DOI] [Full Text] [Details]
(2009) 'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'
Plichta, K. L., Joyce, S. A., Clarke, D. J., Waterfield, N. and Stock, S. P. ; (2009) 'Heterorhabditis gerrardi n. sp. (Nematoda: Heterorhabditidae): the hidden host of Photorhabdus asymbiotica (Enterobacteriaceae: gamma-Proteobacteria)'. Journal of Helminthology, 16 :1-12 [Details]
(2008) 'Bacterial biosynthesis of a multipotent stilbene'
Joyce, S. A.,Brachmann, A. O.,Glazer, I.,Lango, L.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2008) 'Bacterial biosynthesis of a multipotent stilbene'. Angew Chem Int Ed Engl, 47 (10):1942-5 [Details]
(2007) 'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'
Eleftherianos, Ioannis; Boundy, Sam; Joyce, Susan A.; Aslam, Shazia; Marshall, James W.; Cox, Russell J.; Simpson, Thomas J.; Clarke, David J.; ffrench-Constant, Richard H.; Reynolds, Stuart E. (2007) 'An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition'. Proceedings of The National Acadamy of Sciences, 104 (7):2419-24 [ Publisher's Version] [DOI] [Details]
(2007) 'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'
Brachmann, A. O.,Joyce, S. A.,Jenke-Kodama, H.,Schwar, G.,Clarke, D. J.,Bode, H. B.; (2007) 'A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens'. Chembiochem, 8 (14):1721-8 [Details]
(2006) 'Nematode Symbiont for Photorhabdus asymbiotica'
Gerrard, John; Joyce, Susan; Clarke, David; ffrench-Constant, Richard; Nimmo, Graeme; Looke, David, F. M.; Feil, Edward; Pearce, Lucy; Waterfield, Nick (2006) 'Nematode Symbiont for Photorhabdus asymbiotica'. Emerging Infectious Disease Journal, 12 (10):1562-1564 [ Publisher's Version] [DOI] [Full Text] [Details]
(2006) 'The regulation of pathogenicity and mutualism in Photorhabdus'
Joyce, S. A.,Watson, R. J.,Clarke, D. J.; (2006) 'The regulation of pathogenicity and mutualism in Photorhabdus'. Curr Opin Microbiol, 9 (2):127-32 [Details]
(2005) 'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'
Watson, R. J.,Joyce, S. A.,Spencer, G. V.,Clarke, D. J.; (2005) 'The exbD gene of Photorhabdus temperata is required for full virulence in insects and symbiosis with the nematode Heterorhabditis'. Mol Microbiol, 56 (3):763-73 [Details]
(2003) 'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'
Joyce, S. A.,Clarke, D. J.; (2003) 'A hexA homologue from Photorhabdus regulates pathogenicity, symbiosis and phenotypic variation'. Mol Microbiol, 47 (5):1445-57 [Details]
(2003) 'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'
ffrench-Constant R, Waterfield N, Daborn P, Joyce S, Bennett H, Au C, Dowling A, Boundy S,Reynolds S, Clarke D. (2003) 'Photorhabdus: towards a functional genomic analysis of a symbiont and pathogen'. Fems Microbiology Letts, [Details]
(2002) 'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'
Joyce SA, Dorman CJ. (2002) 'A Rho-dependent phase-variable transcription terminator controls expression of the FimE recombinase in Escherichia coli'. Molecular Microbiology, 45 (4):1107-1117 [Details]
(2002) 'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'
Clarke, D. J.,Joyce, S. A.,Toutain, C. M.,Jacq, A.,Holland, I. B.; (2002) 'Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12'. J Bacteriol, 184 (4):1204-8 [Details]
(2000) 'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'
Beletskii A, Grigoriev A, Joyce S, Bhagwat AS. (2000) 'Mutations induced by bacteriophage T7 RNA polymerase and their effects on the composition of the T7 genome'. Journal of Molecular Biology, 300 :1057-1065 [Details]
(1999) '5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'
Joyce, S. A. and Dreyfus M.D (1999) '5' stabilizers are ineffective in stabilizing the Ecsherichia coli lacZ mRNA requires not only ribosome binding, but also translation'. Journal of Molecular Biology, 282 :241-254 [Details]
(1999) 'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'
Lopez PJ, Marchand I, Joyce SA, Dreyfus M (1999) 'The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo'. Molecular Microbiology, 33 :188-199 [Details]
(1994) 'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'
Joyce, Susan A.; Burnell, Ann M.; Powers, Thomas O. (1994) 'Characterization of Heterorhabditis Isolates by PCR Amplification of Segments of mtDNA and rDNA Genes'. Journal of Nematology, 26 (3):260-270 [ Publisher's Version] [Full Text] [Details]

Note

  Year Publication
(2008) Photorhabdus: Shedding light on.
Joyce S.;Clarke D. (2008) Photorhabdus: Shedding light on. Note [Details]

Reviews

  Year Publication
(2021) Dietary fibre modulates the gut microbiota.
Cronin P.;Joyce S.A.;O’toole P.W.;O’connor E.M. (2021) Dietary fibre modulates the gut microbiota. Reviews [DOI] [Details]
(2016) The impact of the gut microbiota on drug metabolism and clinical outcome.
Enright E.;Gahan C.;Joyce S.;Griffin B. (2016) The impact of the gut microbiota on drug metabolism and clinical outcome. Reviews [Details]

Honours and Awards

  Year Title Awarding Body
2022 2022 Nomination for Presidents Award for Excellence in Teaching UCC
2021 2021 Irish Research Council Ally Award for Mentorship Irish Research Council
2018 2018 Aurora Participation Award from UCC UCC
2014 Numerous conference poster prizes Onwards
2013 2013 APC Microbiome Ireland Research Person APC Microbiome Ireland

Professional Associations

  Association Function From / To
2021-2025: Director MRes Programme Biochemistry and Biosciences Redesign, Re-validate, Reinvigorate, Recruit 01-OCT-21 / 12-JAN-25
2021-2024: Irish Mass Spectrometry Society Vice Chair Vice Chair 01-DEC-21 / 01-OCT-24
2018: Secretary of Irish Mass Spectrometry Society Committee Secretary Committee/Management member 01-DEC-19 / 01-DEC-21
2022+: EU Horizon Europe Application Evaluator Evaluator 10-JUN-22 /
2022+: IFUT Committee Member Committee Member 07-JUN-22 /
2021+: Member COST Action EpiLipidNET Member 01-JUN-21 /
2019: Member of COST Action NutRedOx Member 01-JUN-19 /
NiBrt Cell and Gene Therapy Forum Committee Member - strategy, information dissemination - education engagement with an industry focus 28-SEP-21 /
2017+: Invited and trained Interview Board /Panel for Teasgasc Interview Board /Panel Teasgasc 01-MAY-19 /
2014-2018: Atlantia Clinical Studies Science Advisory role Science Advisory role 01-JAN-14 /
2017+: Member of Metabolomics Society Interaction 29-JAN-17 /
2000+: Member of Biochemical Society Member 01-JAN-00 /
2000+: Member of Microbiology Society Member 01-JAN-00 /
2014: IFUT Member Committee Member 01-JAN-14 /

Patents

  Patent Number Title Granted
11194PC00 EPO 2014: METHODS OF REGULATING WEIGHT GAIN 12-JUN-14

Conference Contributions

  Year Publication
(2017) International Journal of Surgery,
JA Elliott, CF Murphy, NG Docherty, SL Doyle, AL Gallardo, C Gahan, S Joyce, N Ravi, JV Reynolds, CW le Roux (2017) Pathophysiologic Gut Hormone and Bile Acid Signalling After Oesophagectomy: Implications for Appetite, Postprandial Hypoglycaemia and Nutritional Status in Survivorship. [Invited Lectures (Conference)], International Journal of Surgery, US . [Details]

Disclosures

  Title Inventor Submitted
2021: Behaviour altering Microbia (with Cryan group) with APC Microbiome Ireland

Committees

  Committee Function From / To
Digital Badge in Research and Innovation Design, input and support 2022 / 2023
2022-2024: Vice Chair College of SEFS Research and Innovation Committee Vice Chair 2022 / 2024
2019: Chair and Member of School of Biochemistry and Cell Biology Research Committee -School and College Chair - School, Member - 2019 /
2020: Member of Research and Innovation Committee SEFS Member 2020 /
2020: School of Biochemistry and Cell Biology Athena Swan SAT Bronze Award: WG Leader Group Task leader 2020 /
2021: School of Biochemistry and Cell Biology EDI Committee member WG Lead 2021 /
2019-2021: Medicine & Health Degree Curriculum Committee Curriculum and Programme development 2019 / 2021
2021: Panel for Grant assessment of Waterford IT Excellence Awards Committee member 2021 / 2021
2021: Grant reviewer for Agence Nationale de la Recherche Grant Reviewer 2021 /
2019, 20, 21 Reviewer for European Science Foundation Reviewer 2019 /
2020: Grant Reviewer European Science Foundation Grant Reviewer 2020 /
2022: External Evaluator to SETU & Waterford IT PhD Programme scholarship awards Evaluator 2022 /
2019: FWO Grant reviewer for Belgian public research funding organisation 2019 FWO Grant reviewer for Belgian public research funding organisation 2019 /
2019-21: ANR French National Research Agency Grant Reviewer Grant reviewer 2019 / 2021
2017: Reviewer for The Austrian Science Fund Grant reviewer 2017 /
2016: In House Institute Pasteur Grant Reviewer Grant reviewer -intermittently 2016 /
2021: IMSS Annual Meeting Organizing Committee Committee member 2021 /
2018: Member Graduate Studies Committee- School Level Committee member 2018 /
2022: External Examiner to PhD thesis of Dr Duha Alkhder University of Warick Examiner 2022 / 2022
2020: External Examiner Institute Pasteur Dr Nathalie Bechon PhD Thesis Examiner 2020 /
2022: Independent Chair For Thesis Defence of Dr Tim Fass Independent Chair 2022 /
2020: Independent Chair PhD examination Dr Orla Power Independent Chair 2020 /
2021: Internal Examiner Thesis Commitee Dr David Goulding Thesis Commitee David Goulding 2021 /
2019: PhD thesis Examiner Dr Sreeram Udayan Internal Examination 2019 /
2020; 2021: Interview and selection Panel SEFS WiSTEM2D Interview and selection 2020 /
2021: Member of Green Campus Intiative: Lab assessment Participant 2021 / 2021
2018-22: onwards Scientific Advisory Board Pavol Jozef Šafárik University in Slovakia Grants, Science advisory 2018 /
2021: Organizing Committee for online APC Microbiome Ireland Annual conference Organizing committee 2021 /
2015-21 Direct Entry Medicine Yr1& 2 Examinations, Marks and Standards Examination Board School of Medicine Information, co-ordination, Standards 2015 / 2021
2015: School of Biochemistry and Cell Biology Teaching Review Commitee Report construction 2015 /

Education

  Year Institution Qualification Subject
2020 Cold Spring Harbour (Online) 2020 Certificate in Proteomics Proteomics
2020 LAST Ireland 2020 LAST Ireland Individual Investigators Licence Animal ethics and applications
2011 UCC 2011 PGCE Post graduate Certificate in Teaching for learning and Understanding Pedogogy of Teaching
2011 Waters Ltd 2011 Certificate Small Molecule Detection and Analysis Small Molecule Detection and Analysis
2011 UCC 2011 Post Graduate Cert in Education Teaching & Learning
2007 Bath University 2007 Certificate in Management Management
2008 LAST Ireland 2008 Certificate - Animal studies Animal Handling and Regulations

Languages

  Language Reading Writing Speaking
English Fluent Fluent Fluent
French Fluent Functional Fluent

Outreach Activities

  Description

Research News report https://www.bbc.com/news/world-europe-27294763

Demonstration and talks on gut Health

Hosting TY students either individually or in groups annually. Hosted 2 students BT Young scientist (2019)

Post public seminar discussion lead :You tube: 253 views https://www.youtube.com/watch?v=CCiXcfti4Y4

04032021 Personal view as a female scientist https://apc.ucc.ie/international-womens-day/

2021 Career Journey presentation and discussion to Post Docs APC Microbiome Ireland

2021: Public On line Seminar Can we shape our microbiomes with food and viruses

Jan 2019 -News paper article: Research to lay public: https://www.farminglife.com/business/ps750k-funding-three-agri-food-research-projects-137587

Education and Outreach Committee member APC Microbiome Institute

2019 Cornstore Restaurant Limerick - Food for health

Cornstore restaurant Cork- Food for health 2018 Talks to general public on obesity and Microbiome research

2018 BBC4 Podcast Contributor: The second genome >6Million Downloads https://www.bbc.co.uk/programmes/b09yddx5

2018 Ambassador Aurora Leadership Programme for women

2016 Cork City Gaol - Public Information -Science week 2016

December 2015: Food for health https://www.irishtimes.com/news/science/keep-the-christmas-dinner-safe-from-merry-microbes-1.2457464

2015 Open Science Exhibition CIT

2014 RTE News: Gut microbes and Obesity https://www.rte.ie/news/2014/0506/615513-ucc-bacteria-obesity/

2014: Obesity and Gut bacteria https://www.irishexaminer.com/news/arid-20267601.html

World IBD Day Talk 2014 - talk and discussion with patients CUH

Journal Activities

  Journal Role To / From
Frontiers In Nutrition Member of Editorial Board 24-APR-21 -
Canadian Liver Journal Member of Editorial Board 17-DEC-20 -
Frontiers In Nutrition Referee 24-APR-17 -
Scientific Reports Referee 01-JAN-18 -
Journal Of Receptors And Signal Transduction Referee 01-JAN-19 -
Bmc Genomics Referee 01-JAN-19 -
Future Microbiology Referee 01-JAN-19 -
Infection And Immunity Referee 01-JAN-16 -
Journal Of Functional Foods Referee 01-JUN-16 -
Journal Of Applied Microbiology Referee 01-JAN-15 -
Letters In Applied Microbiology Referee 01-JAN-15 -
Plos One Referee 01-JAN-16 -

Other Activities

  Description

Conference Organization:

  • 2022-23: Annual Irish Mass Spectrometry Society:  meeting May 2022, May 2023 Organizing Committee
  • 2021: Annual Irish Mass Spectrometry Society Meeting : On line meeting May 2021 Organizing Committee and Session Chair
  • 2021: APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance: APC Microbiome Ireland Community & International Speakers: Committee


2017 on:  Annual attendance to SFI Summit
Exploring strategy, good science, interactive workshops and future initiatives

2016 Invited member of the Pharmabiotic Research Institute France – links industry to individuals and determines strategy in Europe for microbiome and gut health

2016 Microbiology Society microbiome research stakeholder Forum, including government ministers,  workshop in Dublin on 15th November 2016 in order to determine strategies in microbiome research for the future.

2014 on: +Investigator APC Microbiome Ireland: Funded research,  reporting, interaction and delivery on SFI funded activities within the center.  Discussion with science advisory board and brainstorming sessions thereafter.

Viva Voce roles:
  • Supervisor of 8 completed PhD students (1 ex UCC)
  • Supervisor of 2 completed MRes Major Masters research thesis at UCC (+2 ex UCC)
  • Chair for UCC SEFS PhD Candidate Thesis Defense ((x2)Power & FASS)
  • Internal examiner for UCC PhD Defense ((x2) Udayan & Goulding)
  • External Examiner ((x3) PhD thesis Defense (Bechon, Institute Pasteur, Paris; Alkhder; University of Warwick, UK;) Master thesis (Quach, Murdoch Childrens Research Institute, Melbourne, Australia).

Since 2018: Seminars: 17 invited presentation/seminars,  Posters:18 – SAJ Invited speaker*/Keynote**:
  • Irish Mass Spectrometry Society Meeting 2022 Dublin Ireland; 2 posters
  • Probiotics, Prebiotics & New food -Symposium Rome ,Italy 13th September 2021*
  • Microbiology Society UK and Ireland 28th April 2021 ** Online
  • Irish Mass Spectrometry Meeting May 2021 – Dublin, Ireland,1 post doc presentation, 4 posters
  • University College Cork Medical Research and Technology conference November 2020*
  • Science Week Public forum 11th November 2020
  • 8th Microbiome Research and Development Industry Conference Online November 2020**
  • APC Virtual Symposium on Non-communicable diseases and antimicrobial resistance, APC Microbiome Ireland : Post doctoral Talk Dr Anirudh Jaisimha
  • Irish Mass Spectrometry Meeting Dublin, Ireland May 2019* 3 posters
  • Infection and Immunity Microbiome Symposium Bristol April 2019**
  • Cost action Nutredox Conference October Luxemburg 2019*
  • The International Scientific Conference on Probiotics and Prebiotics 2018 Budapest$*
  • Keystone Symposium,  Canada 2018$**
  • World Congress in Gastroenterology Rome, Italy 2018$**
  • 7th International Human Microbiome Conference Kerry Ireland 2018$ – 10 Posters; 3rd prize of 300 posters
  • Falk Bile acids conference Dublin 2018$ -2 posters
  • Wellcome- Cambridge- Microbiome December$ 2018*

2019 Hosted Dalila Paladino Erasmus student

2018 Hosted Erasmus student Silvia Palladinelli – Italy-6 months

2018 Hosted Jinchi Jiang – China –12 months- registered with SEFS Chinese government Scholar

2017 Hosted Cheri Amana M.Ed placement
Cheri was seeking a host to finish her on line MEd whilst actively teaching.  Her teaching qualification was in the biological sciences. She performed her placement, in my group and successfully reported on the research she performed to gain her qualification

2017 Hosted Exchange PhD studentDr Roberta Prete – Italy – 18 months

Teaching Interests

I teach within the areas of my research interests: Human,  Cellular and Bacteria Metabolism. Signalling. Food-Microbe-Host interactions. Metabolites. Molecular biology and biochemistry of Metabolism.  Translational Health and Genetics.  Genetics and Gene regulation - human and microbial.

My formal teaching is aligned to different formats: Formal lectures; small group learning (tutorials/workshops/practicals); On line CANVAS recordings and supports (student centered learning tools and assessments (ebooks), simulated practicals (Labster); flipped classrooms; smaller group discussions or breakout rooms. 

A complete and detailed outline of my UG, PG, Research Led Teaching teaching is available here: https://www.dropbox.com/s/e5hewhajdv0lgha/JOYCE%20UG%20and%20PG%20Teaching%20outline.pdf?dl=0

Undergraduate modules currently taught (or in past 5 years or longer):

  • BC1024: (10 credit) Introduction to Biomolecules and Metabolic Pathways. 20 contact hours lectures/tutorials; A core module for Dentistry students.  A further 38 hours are delivered by 2 contributors. From AY21-22.  (Module Coordinator) and co-taught with:
  • BC1334: (10 credit) Biochemistry. 24 contact hours lectures/tutorials; A core module for Pharmacy students.  Further 24 hours are delivered by 1 contributor. From AY21-22 (Module Coordinator)
  • BC2024: (5 Credit) Molecular Biology and Gene Regulation in Health & Disease. 11 contact hours to BSc Medical and Health Sciences students Delivered in AY19,20
  • BC3002: (5 credit) Advanced metabolism in health disease and cancer. 24 contact hours. To Biomedical Science (professional degree) students. (Module Coordinator)  co-taught with:
  •  BC4016: (5 credit) Advanced metabolism in health disease and cancer. 24 contact hours. To Biochemistry  students (Module Coordinator) From AY15 to present (AY15+)
  • BC3012:   Literature Project: (Av. 4 students x15 contact hrs).  Core module for Biochemistry III AY16+
  • FM1040: (10 Credits) Foundations of Medicine: Gastrointestinal, Nutritional & Metabolic Biology Core module DEMI. 30 contact hours lectures/tutorials to Direct Entry Medicine professional degree students. It combines 3 disciplines: Anatomy, Physiology, Biochemistry (Module Coordinator)  Taught and co-ordinated from AY15 to AY20-21. Co-taught from AY18 with:
  • MH1040: (10 Credits)Foundations of Medicine: Gastrointestinal, Nutritional & Metabolic Biology Core module for MHBSc I. 30 contact hours lectures/tutorials  (Module Coordinator) AY18-20-21
  • MH1050: (5 Credits) Translational Medicine: Core module for MHBSc I. 4 contact hour lectures. 
  • BC4012: (15 Credit) Research Projects for FYP Biochemistry BSc Year 4: FYP Biochemistry BSc: 160 contact hours (40/student) for project design, supervision, interpretation, presentation. From 2015 –22, 25 students (3-4 /year) engaged for independent laboratory-based research projects (40 contact hours/ student)
  • MH4010: (20 Credits)Translational Medicine: Core module for MHBSc 4 engaged for independent laboratory-based research projects (60 contact hours/ student) Commenced AY21-22: 1 student

Post Graduate Digital Badge Design in Progress:
Design, input, future launch Digital Badge in  Innovation as part of SEFS initiative with Dr Ger McGlacken and Dr Karen McCarthy, Research and Innovation

Post-graduate modules currently taught: 
  • Director of MRes in Biochemistry and Biosciences (formerly MRes in Biochemistry and Cell Biology)  Reinvigorated the programme, post stakeholder survey and consultation,  to include flexibility. Impact: Highest number of recruits to the programme from 2022-2023
  • PG6004: (5 Credits) Scientific Research Planning and Proposals to MRes and PhD students; 5 x 3hr(s) Interactive and assignment based Workshops (15 contact hours). (Module Coordinator) AY21+   1 case study with guest speaker /week for 1 hour.


Research led teaching:
My group consists normally of 11 (9 core) scientists at different stages of development:
Nominated (by team members ) and awarded for Irish Research Council Ally award for mentorship
  • Current strategic, oversight and direction as main supervisor to 2 PhD students (Killian & Quilter), 1 MRes student (Butler).  Funding in place and recruiting 1 post doctoral researcher, 2 PhD students (SFI funding) and 1x2 year MSc student (Industry) incoming April 2023 (see funding stream).
  • Supporting and co-directing (as co-supervisor) 3 PhD students (40-33%) (Zhang, Saiz, Cronin).
  • Directing, shaping and influencing the science and careers of 2 Post doctoral scientists, both mentored and currently supported by independent funding (Hayoun, Ryan)
  • Directing and influencing the work and career of 1 Research Assistant (Kabir)

Other:
Responsible for initiating the School of Biochemistry and Cell Biology Summer Bursary scheme 2017-2019, now passed on to our School Teaching, Learning & Curriculum Committee.

IMPACT: More than 25 students have benefited from training, networking and opportunity in a professional research environment.  Many have now progressed to higher degrees (MSc, PhD) within or outside of UCC

In School roles to influence UG and PG teaching:
  • Chair of the Research Committee, delivering and advocating SEFS and UCC strategic policies and oversight to our School; encouraging awareness and interaction among our and the broader research community; supporting awareness of funding opportunities through newsletters;  bringing together excellent science and scientists  through strategic planning, oversight (with colleagues) of our School seminar series. During this time, funding, publications, EU applications, postgraduate student numbers have increased significantly.
  • Support and input to shape policy and strategy as a member of Graduate Studies Committee
  • Strategised and developed EDI policy as a member & Working Group Leader of Athena Swan (SAT) Bronze award application 2019- Oct 2021; Produced 3x School Induction Handbooks (Staff, Postdoctoral, Student) to ease and inform entry to our School system, culture and policies.

College Level roles to influence UG & PG Teaching:
  • Member of College Council; Input to strategy at College level
  • SEFS Research & Innovation Committee Vice Chair from 2022 Member since 2020:  Shaping and developing policy, engaging to to implement College and UCC policy and commitments. Piloting new actions for New Connections and in support of strategic plans and objectives. SDG Champion. Developed School Strategy for Europe
  • IFUT Committee member: engaging for the common good

















Recent Postgraduates

  Graduation Year Student Name Institution Degree Type Thesis Title
2025 Qiao Xiao UCC PHD
2024 Gonzalo Saiz UCC PHD
2023 Peter Cronin 2018-2023 University of Limerick PHD
2026 Emily Butler UCC PHD Early life microbial metabolism
2024 Karina Quilter 2019-2024 UCC PHD Awarded
2023 Kieran Power UCC MSc Bioinformatics
2023 Christina Killian Jan 2017 University College Cork PHD Granted May 2023 Main SUPERVISOR: The microbiome - influences in aging
2022 Keith O'Donoghue NUI (UCC) PHD CO-SUPERVISOR: Main: Towards a translational understanding of colonic bacteria in Crohn’s disease pathology
2022 Padraig O'Brien UCC MSc Bioinformatics Sole Supervisor: Genomic analysis of early gut colonizers -
2021 Shane O'Dwyer MSc UCC MSc Sole Supervisor: The microbiome in aging
2021 David Cussens UCC MSc Sole Supervisor: C.elegans and the microbiome in aging
2020 Jonathan Keane Oct 2015 NUI (UCC) PHD Main Supervisor: Changes in the gut microbiota in CRC- cause or consequence
2020 Ciara O'Donovan NUI (UCC) PHD Co-Supervisor 33% Elucidating the Microbiome of Irish Athletes
2020 Elaine Enright Oct 2016 NUI (UCC) PHD Main Supervisor: Gut microbiota mediated bile acid metabolism
2019 Sam Walsh UCC MSc Sole Supervisor: MSc Aging in C.elegans - a microbial perspective
2019 Peter Cronin UCC M.Sc. (with distinction) Sole Supervisor: Major Research Thesis MRes Metabolism in CRC -
2019 Sarah Louise Long Oct 2015 UCC PHD DOCTOR OF PHYSICAL SCIENCES To Jan 2019 Sole Supervisor: Bacterial Bile salt Hydrolase - from selection to impact
2018 Ashling Clifford UCC MSc Sole Supervisor: Cloning and expression of bile altering enzymes
2017 Maurice Stanley UCC Msc Main Supervisor: Major Research thesis MRes: Diet effects in genetic and chemical models of IBD
2015 Sarah Conroy UCC MSc Sole Supervisor: Microbial alterations to host metabolites
2014 Stephen Butler UCC MSc Sole Supervisor
2014 Sinead Griffin UCC MSc Sole Supervisor: In vivo conversion of Bile acids
2013 Aoife Redmond UCC MSc Sole Supervisor
2012 Ciara Morgan UCC MSc Co Supervisor
2012 Catherine Easom UCC PHD Co Supervisor 50%

Internal Collaborators

  Name Institute Country
Dr David Clarke School of Microbiology IRELAND
Prof John Cryan UCC IRELAND
Prof Dmitri Papkovsky UCC IRELAND
Prof Jens Walter UCC IRELAND
Dr Dervla O'Malley UCC IRELAND
Dr Marcus Claesson UCC
Dr Silvia Melgar APC Microbiome Institute

External Collaborators

  Name Organisation / Institute Country
Dr Carel La Roux UCD IRELAND
Prof Paul Cotter Teagasc Moorepark IRELAND
Dr Eibhlis O'Connor University of Limerick IRELAND
Dr Kieran Tuohy FEMS Italy
Dr Julie Lovegrove University of Reading
Dr Orla O'Sullivan Teagasc, Moorepark IRELAND
Dr Irina Tikonova Queens University of Belfast UNITED KINGDOM
Prof. Jun Lin University of Knoxville U.S.A.
Dr Prue Pereira Murdochs Childrens Research Institute AUSTRALIA