TY  - JOUR
  - O'Sullivan, O,Coakley, M,Lakshminarayanan, B,Conde, S,Claesson, MJ,Cusack, S,Fitzgerald, AP,O'Toole, PW,Stanton, C,Ross, RP
  - 2013
  - January
  - Journal of Antimicrobial Chemotherapy
  - Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy
  - Published
  - ()
  - antibiotics culturable unculturable 16S rRNA gene amplicon sequencing HUMAN GUT MICROBIOTA ANTIBIOTIC-RESISTANCE FECAL MICROBIOTA COLITIS DISEASE HEALTH FLORA AGE BACTERIA IMPACTS
  - 68
  - 214
  - 221
  - The human intestinal microbiota composition alters naturally with age, but is unusually perturbed by antibiotic therapy. The impact of antibiotic therapy on the composition of the intestinal microbiota of a cross-section of elderly Irish subjects (n185, epsilon 65 years) was investigated, taking into consideration their residence location.Forty-two of the 185 elderly subjects were treated with at least one antibiotic within 1 month prior to faecal microbiota profiling. The residence locations of the subjects varied from long-term nursing care and rehabilitation wards to day hospitals and the community.Culture-dependent methods indicated that faecal Bifidobacterium spp. numbers were significantly reduced following antibiotic treatment (P0.004, 7-fold reduction), while levels of Lactobacillus spp. and Enterobacteriaceae were unaffected. The largest decrease in Bifidobacterium spp. numbers was linked to the administration of nucleic acid synthesis inhibitors (P0.004, 23-fold reduction). Microbiota profiling revealed a significant compositional change across nine genera following antibiotic therapy, including a relative increase in Lactobacillus spp. (P0.031), as well as a decrease in the number of genera identified in the antibiotic-treated subjects (n58), when compared with untreated subjects (n79). More alterations in the intestinal microbiota were observed post-nucleic acid synthesis inhibitor therapy, most notably a decrease in relative Faecalibacterium spp. numbers (P0.001).The impact of antibiotic therapy on the intestinal microbiota in the elderly should be considered for long-term health effects, and differential susceptibility may require the development of products (e.g. prebiotics and probiotics) for at-risk subjects.
  - DOI 10.1093/jac/dks348
DA  - 2013/01
ER  - 

@article{V206308271,
   = {O'Sullivan,  O and Coakley,  M and Lakshminarayanan,  B and Conde,  S and Claesson,  MJ and Cusack,  S and Fitzgerald,  AP and O'Toole,  PW and Stanton,  C and Ross,  RP },
   = {2013},
   = {January},
   = {Journal of Antimicrobial Chemotherapy},
   = {Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy},
   = {Published},
   = {()},
   = {antibiotics culturable unculturable 16S rRNA gene amplicon sequencing HUMAN GUT MICROBIOTA ANTIBIOTIC-RESISTANCE FECAL MICROBIOTA COLITIS DISEASE HEALTH FLORA AGE BACTERIA IMPACTS},
   = {68},
  pages = {214--221},
   = {{The human intestinal microbiota composition alters naturally with age, but is unusually perturbed by antibiotic therapy. The impact of antibiotic therapy on the composition of the intestinal microbiota of a cross-section of elderly Irish subjects (n185, epsilon 65 years) was investigated, taking into consideration their residence location.Forty-two of the 185 elderly subjects were treated with at least one antibiotic within 1 month prior to faecal microbiota profiling. The residence locations of the subjects varied from long-term nursing care and rehabilitation wards to day hospitals and the community.Culture-dependent methods indicated that faecal Bifidobacterium spp. numbers were significantly reduced following antibiotic treatment (P0.004, 7-fold reduction), while levels of Lactobacillus spp. and Enterobacteriaceae were unaffected. The largest decrease in Bifidobacterium spp. numbers was linked to the administration of nucleic acid synthesis inhibitors (P0.004, 23-fold reduction). Microbiota profiling revealed a significant compositional change across nine genera following antibiotic therapy, including a relative increase in Lactobacillus spp. (P0.031), as well as a decrease in the number of genera identified in the antibiotic-treated subjects (n58), when compared with untreated subjects (n79). More alterations in the intestinal microbiota were observed post-nucleic acid synthesis inhibitor therapy, most notably a decrease in relative Faecalibacterium spp. numbers (P0.001).The impact of antibiotic therapy on the intestinal microbiota in the elderly should be considered for long-term health effects, and differential susceptibility may require the development of products (e.g. prebiotics and probiotics) for at-risk subjects.}},
   = {DOI 10.1093/jac/dks348},
  source = {IRIS}
}