Biography

Dr Andrew Lindsay is a graduate of Trinity College Dublin and obtained a PhD from University College Cork. He has previously worked in the Department of Medical and Molecular Genetics in the Indiana University School of Medicine and at the Institut Curie, Paris. He is currently a lecturer in the School of Biochemistry and Cell Biology, UCC.

His group studies the endosomal recycling pathway, and the role that its dysregulation plays in the aggressiveness of certain cancers. This pathway is the main cellular mechanism for controlling the composition of the plasma membrane.  Research from his lab has shown that inhibiting endosomal recycling reduces the metastatic potential of cancer cells, and can also enhance the effectiveness of a number of targeted therapies.

Dr Lindsay has received a number of grants including a HRB Career Development Award and a prestigious Marie Curie Research Fellowship. The main focus of his laboratory is to characterize the role that dysregulated membrane trafficking pathways play in the development and aggressiveness of cancer and to identify small-molecule inhibitors of the endosomal recycling pathway that may be useful as novel anti-cancer therapies.

Research Interests

My research is focused primarily on the study of intracellular membrane trafficking, in particular the endosomal recycling pathway. This pathway is the main cellular mechanism for controlling the composition of the plasma membrane. Receptor tyrosine kinases (RTKs), integrins, G-protein coupled receptors, matrix metalloproteinases (MMPs), and cadherins are examples of cell surface proteins that undergo endocytic recycling. Defects in this pathway have been linked to a number of diseases including neurological disorders such as Huntington’s disease and Griscelli’s Syndrome Type I, and intestinal disorders such as microvillus inclusion disease. Furthermore, a number of intracellular pathogens such as HIV and Chlamydia trachomatis ‘hijack’ the endosomal recycling pathway during their life cycle.

In recent years it has emerged that aberrant expression of key regulators of endosomal recycling can lead to the increased aggressiveness of a wide range of cancers. One such regulator is a protein that I identified during my PhD called Rab Coupling Protein (RCP). The RCP gene is frequently amplified in breast cancer and has been found to be a breast cancer promoting gene. Downregulation of RCP inhibits the motility and invasiveness (key properties of metastatic tumour cells) of lung and breast cancer cells.

The main goals of my research are to gain a greater understanding of the role that a malfunctioning endosomal recycling pathway plays in cancer metastasis, with a view to identifying novel therapeutic targets. Greater than 90% of all deaths caused by solid cancers result from metastasis, i.e. the formation of secondary tumours in distant organs such as the lungs, liver, brain and bone. Given the importance of the endosomal recycling pathway in mediating the aggressiveness of cancers (likely due to biased recycling of adhesion molecules, MMPs, integrins, and RTKs), a major focus is to identify inhibitors of endosomal recycling that will have therapeutic potential as anti-metastatic cancer drugs.

 We use a wide range of techniques including molecular biology, bioinformatics, protein biochemistry, cell culture, genetics, and fluorescent imaging. In particular I would consider myself to be a specialist in advanced cell imaging. I regularly use cutting edge techniques such as FRET, FRAP, super resolution microscopy, TIRF, quantitative colocalisation analysis etc.

 

Research Grants

  Project Funding
Body 		Start Date End Date Award
AL BC PhD Award Miscellaneous 01-OCT-20 30-SEP-23 €64,000.00
SFI Research Infrastructure 2015 (Category D: Opportunistic Funding); Sub-project of R17475; 16/RI/3404 Science Foundation of Ireland 01-JAN-17 30-JUN-19 €99,919.00
Characterisation of the Role of the Human Myosin V Family in Cell Division and Disease. Health Research Board 01-OCT-05 30-SEP-08 €225,000.00
Characterisation of the Role and Regulation of Myosin Va in Membrane Transport and Disease Health Research Board 01-JAN-10 01-FEB-13 €280,186.00

Peer Reviewed Journals

  Year Publication
(2023) 'Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin'
Mendonça MCP;Sun Y;Cronin MF;Lindsay AJ;Cryan JF;O'Driscoll CM; (2023) 'Cyclodextrin-Based Nanoparticles for Delivery of Antisense Oligonucleotides Targeting Huntingtin'. Pharmaceutics, 15 (2) [DOI] [Details]
(2022) 'Inhibition of the endosomal recycling pathway downregulates HER2 activation and overcomes resistance to tyrosine kinase inhibitors in HER2-positive breast cancer'
Mishra A;Hourigan D;Lindsay AJ; (2022) 'Inhibition of the endosomal recycling pathway downregulates HER2 activation and overcomes resistance to tyrosine kinase inhibitors in HER2-positive breast cancer'. Cancer Letters, 529 [DOI] [Full Text] [Details]
(2022) 'Metalloprotease-Dependent S2 '-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2'
Harte, JV;Wakerlin, SL;Lindsay, AJ;McCarthy, JV;Coleman-Vaughan, C (2022) 'Metalloprotease-Dependent S2 '-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2'. Viruses, 14 [DOI] [Details]
(2022) 'Ryanodine receptor calcium release channels in trophoblasts and their role in cell migration'
Zheng, LM;Lindsay, A;McSweeney, K;Aplin, J;Forbes, K;Smith, S;Tunwell, R;Mackrill, JJ (2022) 'Ryanodine receptor calcium release channels in trophoblasts and their role in cell migration'. Biochimica Et Biophysica Acta-Molecular Cell Research, 1869 [DOI] [Details]
(2020) 'The Endosomal Recycling Pathway-At the Crossroads of the Cell'
O'Sullivan MJ;Lindsay AJ; (2020) 'The Endosomal Recycling Pathway-At the Crossroads of the Cell'. International Journal of Molecular Sciences, 21 (17) [DOI] [Details]
(2019) 'The Parkinson' disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P-3'
Furlong, RM;Lindsay, A;Anderson, KE;Hawkins, PT;Sullivan, AM;O'Neill, C (2019) 'The Parkinson' disease gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P-3'. Journal of Cell Science, 132 [DOI] [Full Text] [Details]
(2019) 'Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking'
Waschbusch, D;Hubel, N;Ossendorf, E;Lobbestael, E;Baekelandt, V;Lindsay, AJ;McCaffrey, MW;Khan, AR;Barnekow, A (2019) 'Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking'. Plos One, 14 [DOI] [Full Text] [Details]
(2017) 'Rab11 family expression in the human placenta: Localization at the maternal-fetal interface'
Taglauer, ES;Artemiuk, PA;Hanscom, SR;Lindsay, AJ;Wuebbolt, D;Breathnach, FM;Tully, EC;Khan, AR;McCaffrey, MW (2017) 'Rab11 family expression in the human placenta: Localization at the maternal-fetal interface'. Plos One, 12 [DOI] [Full Text] [Details]
(2017) 'Regulation of NF-kappa B by PML and PML-RAR alpha'
Ahmed, A;Wan, XC;Mitxitorena, I;Lindsay, AJ;Pandolfi, PP;McCaffrey, MW;Keeshan, K;Chen, YHH;Carmody, RJ (2017) 'Regulation of NF-kappa B by PML and PML-RAR alpha'. Scientific Reports, 7 [DOI] [Details]
(2016) 'Rab coupling protein mediated endosomal recycling of N-cadherin influences cell motility'
Lindsay AJ;McCaffrey MW; (2016) 'Rab coupling protein mediated endosomal recycling of N-cadherin influences cell motility'. Oncotarget, [DOI] [Full Text] [Details]
(2015) 'Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)'
Lall, P;Lindsay, AJ;Hanscom, S;Kecman, T;Taglauer, ES;McVeigh, UM;Franklin, E;McCaffrey, MW;Khan, AR (2015) 'Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)'. Journal of Biological Chemistry, 290 :18817-18832 [DOI] [Details]
(2012) 'Roles for myosin Va in RNA transport and turnover'
McCaffrey, MW;Lindsay, AJ (2012) 'Roles for myosin Va in RNA transport and turnover'. Biochemical Society Transactions, 40 :1416-1420 [DOI] [Details]
(2012) 'Roles for myosin Va in RNA transport and turnover'
McCaffrey M.W., Lindsay A.J. (2012) 'Roles for myosin Va in RNA transport and turnover'. Biochemical Society Transactions, 40 (6):1416-1420 [Details]
(2011) 'Myosin Va Is Required for P Body but Not Stress Granule Formation'
Lindsay, AJ;McCaffrey, MW (2011) 'Myosin Va Is Required for P Body but Not Stress Granule Formation'. Journal of Biological Chemistry, 286 :11519-11528 [DOI] [Details]
(2007) 'Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes'
Welsh GI, Leney SE, Lloyd-Lewis B, Wherlock M, Lindsay AJ, McCaffrey MW, Tavaré JM; (2007) 'Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes'. Journal of cell science, 120 (Pt 23):4197-4208 [DOI] [Details]
(2007) 'Rip11 is a Rab11-and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes'
Welsh, GI;Leney, SE;Lloyd-Lewis, B;Wherlock, M;Lindsay, AJ;McCaffrey, MW;Tavare, JM (2007) 'Rip11 is a Rab11-and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes'. Journal of Cell Science, 120 :4197-4208 [DOI] [Details]
(2006) 'Crystal structure of Rab11 in complex with Rab11 family interacting protein 2'
Jagoe, WN;Lindsay, AJ;Read, RJ;Mccoy, AJ;McCaffrey, MW;Khan, AR (2006) 'Crystal structure of Rab11 in complex with Rab11 family interacting protein 2'. Structure, 14 :1273-1283 [DOI] [Details]
(2004) 'Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment'
Damiani, MT;Pavarotti, M;Leiva, N;Lindsay, AJ;McCaffrey, MW;Colombo, MI (2004) 'Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment'. Traffic, 5 :785-797 [DOI] [Details]
(2004) 'Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis'
Lindsay, AJ;McCaffrey, MW (2004) 'Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis'. Febs Letters, 571 :86-92 [DOI] [Details]
(2002) 'Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells'
Wallace, DME;Lindsay, AJ;Hendrick, AG;McCaffrey, MW (2002) 'Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells'. Biochemical and Biophysical Research Communications, 299 :770-779 [Details]
(2002) 'The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities'
Wallace, DM;Lindsay, AJ;Hendrick, AG;McCaffrey, MW (2002) 'The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities'. Biochemical and Biophysical Research Communications, 292 :909-915 [DOI] [Details]
(2016) 'Congenital macrothrombocytopenia-linked mutations in the actin-binding domain of alpha-actinin-1 enhance F-actin association'
Murphy, ACH;Lindsay, AJ;McCaffrey, MW;Djinovic-Carugo, K;Young, PW (2016) 'Congenital macrothrombocytopenia-linked mutations in the actin-binding domain of alpha-actinin-1 enhance F-actin association'. Febs Letters, 590 :685-695 [DOI] [Details]
(2015) 'Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)'
Lall P, Lindsay AJ;Hanscom S;Kecman T;Taglauer ES;McVeigh UM;Franklin E;McCaffrey MW;Khan AR (2015) 'Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP)'. The Journal of Biological Chemistry, 290 (30):18817-18832 [DOI] [Details]
(2015) 'Analysis of the interactions between Rab GTPases and class V myosins'
Lindsay AJ, Miserey-Lenkei S;Goud B (2015) 'Analysis of the interactions between Rab GTPases and class V myosins'. Methods of Molecular Biology, 1298 :73-83 [DOI] [Details]
(2015) 'Rab antibody characterization: comparison of Rab14 antibodies'
Lindsay AJ, McCaffrey MW (2015) 'Rab antibody characterization: comparison of Rab14 antibodies'. Methods of Molecular Biology, 1298 :161-171 [DOI] [Details]
(2014) 'Myosin Va is required for the transport of fragile X mental retardation protein (FMRP) granules'
Lindsay AJ, McCaffrey MW (2014) 'Myosin Va is required for the transport of fragile X mental retardation protein (FMRP) granules'. Biology of The Cell / Under The Auspices of The European Cell Biology Organization, 106 (2):57-71 [DOI] [Details]
(2013) 'Identification and characterization of multiple novel Rab-myosin Va interactions'
Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW, Goud B (2013) 'Identification and characterization of multiple novel Rab-myosin Va interactions'. Molecular Biology of The Cell, 24 (21):3420-3434 [DOI] [Details]
(2012) 'Roles for myosin Va in RNA transport and turnover'
McCaffrey MW, Lindsay AJ (2012) 'Roles for myosin Va in RNA transport and turnover'. Biochemical Society transactions, 40 (6):1416-1420 [DOI] [Details]
(2010) 'Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis'
Schwertassek U, Buckley DA, Xu CF, Lindsay AJ, McCaffrey MW, Neubert TA, Tonks NK; (2010) 'Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis'. Febs Journal, 277 (11):2463-2473 [DOI] [Details]
(2009) 'Myosin Vb localises to nucleoli and associates with the RNA polymerase I transcription complex'
Lindsay AJ, McCaffrey MW; (2009) 'Myosin Vb localises to nucleoli and associates with the RNA polymerase I transcription complex'. Cell Motility and The Cytoskeleton, [DOI] [Details]
(2008) 'Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments'
Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC; (2008) 'Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments'. The Journal of Cell Biology, 183 (1):143-155 [DOI] [Details]
(2006) 'Purification, crystallization and preliminary X-ray diffraction studies of Rab11 in complex with Rab11-FIP2'
Jagoe WN, Jackson SR, Lindsay AJ, McCaffrey MW, Khan AR; (2006) 'Purification, crystallization and preliminary X-ray diffraction studies of Rab11 in complex with Rab11-FIP2'. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications, 62 (Pt 7):692-694 [DOI] [Details]
(2005) 'Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner'
Marie N, Lindsay AJ, McCaffrey MW; (2005) 'Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner'. The Biochemical Journal, 389 (Pt 1):223-231 [DOI] [Details]
(2005) 'Functional properties of the Rab-binding domain of Rab coupling protein'
Lindsay AJ, Marie N, McCaffrey MW; (2005) 'Functional properties of the Rab-binding domain of Rab coupling protein'. Methods in enzymology, 403 :481-491 [DOI] [Details]
(2005) 'Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner'
Marie, N,Lindsay, AJ,McCaffrey, MW; (2005) 'Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner'. The Biochemical Journal, 389 :223-231 [DOI] [Details]
(2005) 'Purification and functional properties of Rab11-FIP2'
Lindsay AJ, McCaffrey MW; (2005) 'Purification and functional properties of Rab11-FIP2'. Methods In Enzymology, 403 :491-499 [DOI] [Details]
(2004) 'The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane'
Lindsay AJ, McCaffrey MW; (2004) 'The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane'. Journal of Cell Science, 117 (Pt 19):4365-4375 [DOI] [Details]
(2004) 'Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment'
Damiani MT, Pavarotti M, Leiva N, Lindsay AJ, McCaffrey MW, Colombo MI; (2004) 'Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment'. Traffic (Copenhagen, Denmark), 5 (10):785-797 [DOI] [Details]
(2002) 'Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain'
Lindsay, AJ,McCaffrey, MW; (2002) 'Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain'. The Journal of Biological Chemistry, 277 :27193-27199 [DOI] [Details]
(2002) 'Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein'
Lindsay, AJ,Hendrick, AG,Cantalupo, G,Senic-Matuglia, F,Goud, B,Bucci, C,McCaffrey, MW; (2002) 'Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein'. The Journal of Biological Chemistry, 277 :12190-12199 [DOI] [Details]
(2002) 'The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities'
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW; (2002) 'The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities'. Biochemical and Biophysical Research Communications, 292 (4):909-915 [DOI] [Details]
(2002) 'Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells'
Wallace, DME,Lindsay, AJ,Hendrick, AG,McCaffrey, MW; (2002) 'Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells'. Biochemical and Biophysical Research Communications, 299 :770-779 [DOI] [Details]
(1997) 'Acute phase proteins in salmonids: evolutionary analyses and acute phase response'
Jensen LE, Hiney MP, Shields DC, Uhlar CM, Lindsay AJ, Whitehead AS (1997) 'Acute phase proteins in salmonids: evolutionary analyses and acute phase response'. Journal of immunology (Baltimore, Md. : 1950), 158 (1):384-392 [Details]

Book Chapters

  Year Publication
(2023) 'Rabs of the Endosomal Recycling Pathway'
Mishra A, McCaffrey MW, Lindsay AJ (2023) 'Rabs of the Endosomal Recycling Pathway' In: Encyclopedia of Cell Biology, Second Edition. Oxford, UK: Elsevier. [Details]
(2015) 'Rabs of the Endosomal Recycling Pathway'
Lindsay A.J., McCaffrey M.W. (2015) 'Rabs of the Endosomal Recycling Pathway' In: Encyclopedia of Cell Biology. London: Elsevier. [Details]
(2005) 'Functional properties of the Rab-binding domain of Rab coupling protein'
Lindsay, AJ;Marie, N;McCaffrey, MW (2005) 'Functional properties of the Rab-binding domain of Rab coupling protein' In: GTPASES REGULATING MEMBRANE TARGETING AND FUSION. SAN DIEGO: ELSEVIER ACADEMIC PRESS INC. [DOI] [Details]
(2005) 'Purification and functional properties of Rab11-FIP2'
Lindsay, AJ;McCaffrey, MW (2005) 'Purification and functional properties of Rab11-FIP2' In: GTPASES REGULATING MEMBRANE TARGETING AND FUSION. SAN DIEGO: ELSEVIER ACADEMIC PRESS INC. [DOI] [Details]
(2013) 'Rab Family'
McCaffrey M.W., Lindsay A.J. (2013) 'Rab Family' In: Encyclopedia of Biological Chemistry. London: Elsevier. [Details]
(2005) 'Pruification and Functional properties of Rab11-FIP2'
Lindsay, A.J., McCaffrey, M.W.; (2005) 'Pruification and Functional properties of Rab11-FIP2' In: Methods in Enzymology. USA: Academic Press. [Details]
(2005) 'Functional Properties of the Rab-Binding Domain of Rab Coupling Protein'
Lindsay AJ, Marie N, McCaffrey MW (2005) 'Functional Properties of the Rab-Binding Domain of Rab Coupling Protein' In: W. Balch, C. Der, A. Hall (eds). Methods in Enzymology. NA: Academic Press. [Details]
(2005) 'Functional properties of the Rab-Binding Domain of Rab Coupling Protein'
Lindsay, A.J., Marie, N., M.W. McCaffrey; (2005) 'Functional properties of the Rab-Binding Domain of Rab Coupling Protein' In: Methods in Enxymology, 403, GTPases Regulating Membrane Targeting and Fusion. [Details]
(2004) 'The Rab Family'
McCaffrey, M.W., Lindsay, A.J.; (2004) 'The Rab Family' In: Encyclopedia of Biological Chemistry. [Details]

Reviews

  Year Publication
(2020) The Endosomal Recycling Pathway-At the Crossroads of the Cell.
O'Sullivan M.J.;Lindsay A.J. (2020) The Endosomal Recycling Pathway-At the Crossroads of the Cell. Reviews [DOI] [Details]

Professional Associations

  Association Function From / To
Irish Association for Cancer Research IACR /
Biochemical Society Professional Society /
Institute of Leadership and Management Professional Society /
Marie Curie Alumni Association Professional Society /

Committees

  Committee Function From / To
IACR Senior Council UCC Representative /
School of Biochemistry EDI Career Development Section Leader /
School of Biochemistry Health & Safety Academic representative /
SEFS Committee for External Engagement School of Biochemistry & Cell Biology Representative /

Journal Activities

  Journal Role To / From
Cell Proliferation Peer Reviewer -
Cellular Oncology Peer Reviewer -
International Journal Of Molecular Sciences Peer Reviewer -
Journal Of Chemical Education Peer Reviewer -
Frontiers In Oncology Peer Reviewer -
Biomolecules Peer Reviewer -
Frontiers In Cell And Developmental Biology Peer Reviewer -
Cells Peer Reviewer -
Traffic Peer Reviewer -
European Journal Of Human Genetics Editor -
Oncogene Peer Reviewer -
Journal Of Chemical Education Peer Reviewer -
Genes Peer Reviewer -
Journal Of Cell Science Peer Reviewer -
Nature Communications Peer Reviewer -
Journal Of Cell Science Peer Reviewer -
Small Peer Reviewer -

Languages

  Language Reading Writing Speaking
French Functional Functional Functional

Consultancy

  Client Description
European Journal for Human Genetics
Section Editor
Irish Association for Cancer Research
Senior Council member

Outreach Activities

  Description

RTE Brainstorm. Feb 2019

Radio Interview on Kildare FM

RTE Brainstorm article. June 2018

Primary school outreach programme.

Education

  Year Institution Qualification Subject
2016 UCC Postgrad Cert. in Teaching & Learning in HE Teaching and Learning
2017 University College Cork Postgraduate Diploma in Teaching and Learning in Higher Education Teaching and Learning in Higher Education
1996 Trinity College Dublin B.A. (Mod.) Genetics
2002 University College Cork PHD Biochemistry and Cell Biology

Other Activities

  Description

Professional Skills for Research Leaders  - 6 month blended learning programme designed to help individual researchers enhance their approach to leadership, management and engagement run by the Insitute of Leadership and Management (ILM). Received ILM Certificate, December 2015.

International Funders Award in Management Skills for Researchers (2017)

Current Leaders Level 2 Programme - Irish Management Institute (2021)

Occupational First Aid (FETAC Level 5) - Elite Ambulance and Health and Safety, UCC. November 2014

Communication and Media Skills Residential Course – Royal Society, UK. January 2013.

Teaching Interests

I deliver Biotechnology and Genetics lectures to various undergraduate and postgraduate programmes. I have developed and coordinate a number of academic modules and employ a ‘student-centred’ teaching approach.      
  • BT4002 Biotechnology Research Project (Joint module coordinator)    
  • GN1001 Principles and Methods in Genetics (Joint module coordinator) 
  • BT6001 Genetic Engineering (Module Coordinator)
  • BT4004 Microbial biotechnology     
  • GN2001 Current Perspectives in Genetics        
  • GN4002 Genetics Research Project        
  • GN4003 Genomics and Applications
  • GN4004 Genetics and Society
  • ML6004 Cell and Molecular Biology
  • ML6001 Molecular Cell Biology Research Dissertation
  • ML6003 Scientific Communication of Current Topics in Molecular Cell Biology 
  • BC3012 Literature review
  • GN3002 Literature in Genetics
  • FM1010 Introductory Human Biology·         
  • BC3004 Cell Signalling
I am the Deputy Director of the BSc Genetics programme (CK405) and I am a member of the Genetics Course Team and the Biotechnology Board of Studies.

Recent Postgraduates

  Graduation Year Student Name Institution Degree Type Thesis Title
2023 Catherine Johnson University College Cork MSc Biomedical Science Investigating the potential of using endosomal recycling inhibitors as a treatment for non-small cell lung cancer
2020 Mary O'Sullivan University College Cork MSc Biomedical Science The endosomal recycling pathway and cancer
2023 Kelsey Fletcher University College Cork Msc Inhibition of the Endosomal Recycling Pathway to Overcome Resistance to Cancer Therapies
2021 Samantha Wakerlin University College Cork An investigation on the proteolysis of the ACE2 receptor as a gamma-secretase substrate and its involvement in the cellular uptake and trafficking of SARS-CoV-2
2021 Laura Barry University College Cork MSc Biomedical Science The Development of a SARS-CoV-2 Cell-Cell Fusion Assay to Test the Effects of Endosomal Recycling Inhibitors on Spike Protein Binding.
2021 Bernard Foley University College Cork MSc Biomedical Science Development of an in vitro Active Rab11 Trap
2020 Mary O'Sullivan University College Cork MSc Biomedical Science The endosomal recycling pathway and cancer
2020 Eamonn Cooper University College Cork MSc Bioinformatics Identification of genomic alterations in cancer cells that confer sensitivity to membrane trafficking inhibitors
2016 Rachel O'Carroll University College Cork MSc Bioinformatics A Bioinformatic Approach to Investigating The Role of Membrane Trafficking Proteins in Cancer
2019 David Hourigan University College Cork MSc Biomedical Science Derailed endosomal recycling in cancer
2019 Shannon Murphy University College Cork MSc Bioinformatics Exploring cancer genomics databases to generate a signature of endosomal recycling genes altered in different cancer subtypes
2017 Laura Scally University College Cork MSc Biomedical Science Targeting the Endosomal Recycling to Prevent Cancer Metastasis

Current Postgraduate Students

  Student Degree Type
Chembukavu Suraj Narayanan Masters Degree by Research
Mishra Anurag Kumar Doctoral Degree

Internal Collaborators

  Name Institute Country
Paul Young University College Cork IRELAND
Ken Nally School of Biochemistry, UCC IRELAND
John Mackrill Dept Physiology, UCC IRELAND
Justin McCarthy University College Cork IRELAND
Cora O'Neil University College Cork IRELAND

External Collaborators

  Name Organisation / Institute Country
Amir Khan Trinity College Dublin IRELAND
Jeremy Simpson University College Dublin IRELAND
Patrick Caswell University of Manchester UNITED KINGDOM
Jim Norman Beatson Institute SCOTLAND
Bruno Goud Institut Curie FRANCE