Biography

Dr. Joey O'Shea is a Lecturer in Pharmaceutics in the School of Pharmacy, University College Cork. 
He completed his Bachelor of Pharmacy degree in UCC in 2012 and Master of Pharmacy degree in the Royal College of Surgeons in Ireland in 2013. Dr O'Shea completed his Ph.D. in the School of Pharmacy in UCC in 2018. The focus of his doctoral work was on the biopharmaceutical aspects of solid oral dose formulation performance and the predictive capacity of various in vitro, in vivo and in silico methods of characterisation for oral bio-enabling formulations. Following completion of his PhD, Dr O'Shea held numerous positions in the pharmaceutical industry in Ireland, including in formulation development, clinical and regulatory affairs and in process development and technical support. Dr O'Shea returned to academia in November 2019, taking up a role as Lecturer in Pharmaceutics in the School of Pharmacy, UCC. He currently teaches on the M.Pharm. undergraduate programme and on the MSc in Pharmaceutical Technology and Quality Systems, an on line masters course designed to train graduates working in the pharmaceutical industry to become a Qualified Person (QP). 

Book Chapters

  Year Publication
(2022) 'Lipid‐based Formulations'
Joseph P O'Shea, Caitriona M O'Driscoll, Brendan T Griffin (2022) 'Lipid‐based Formulations' In: Edmund S. Kostewicz, Maria Vertzoni, Heather A. E. Benson, Michael S. Roberts (eds). Oral Drug Delivery for Modified Release Formulations. NJ, USA: John Wiley & Sons, Inc. [ Publisher's Version] [DOI] [Details]

Peer Reviewed Journals

  Year Publication
(2024) 'Rationalizing Counterion Selection for the Development of Lipophilic Salts: A Case Study with Venetoclax'
Ryan CD;Griffin BT;O'Shea JP; (2024) 'Rationalizing Counterion Selection for the Development of Lipophilic Salts: A Case Study with Venetoclax'. Molecular Pharmaceutics, 21 (6) [DOI] [Details]
(2024) 'Elucidating the Degradation Pathways of Human Insulin in the Solid State'
Fagan A;Bateman LM;O'Shea JP;Crean AM; (2024) 'Elucidating the Degradation Pathways of Human Insulin in the Solid State'. Journal Of Analysis And Testing, 8 (3) [DOI] [Details]
(2024) 'State-of-the-art and future perspectives in ingestible remotely controlled smart capsules for drug delivery: A GENEGUT review'
Hoffmann SV;O'Shea JP;Galvin P;Jannin V;Griffin BT; (2024) 'State-of-the-art and future perspectives in ingestible remotely controlled smart capsules for drug delivery: A GENEGUT review'. European Journal of Pharmaceutical Sciences, 203 [DOI] [Details]
(2024) 'Exploring career choices of pharmacy graduates over 15 years: A cross-sectional evaluation'
Fitzpatrick KL;Allen EA;Griffin BT;O'Shea JP;Dalton K;Bennett-Lenane H; (2024) 'Exploring career choices of pharmacy graduates over 15 years: A cross-sectional evaluation'. Currents in Pharmacy Teaching and Learning, 16 (5) [DOI] [Details]
(2022) 'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review'
O'Shea JP;Augustijns P;Brandl M;Brayden DJ;Brouwers J;Griffin BT;Holm R;Jacobsen AC;Lennernäs H;Vinarov Z;O'Driscoll CM; (2022) 'Best practices in current models mimicking drug permeability in the gastrointestinal tract - an UNGAP review'. European Journal of Pharmaceutical Sciences, 170 :106098-106133 [DOI] [Details]
(2021) 'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'
Bennett-Lenane, Harriet; Jørgensen, Jacob R.; Koehl, Niklas J.; Henze, Laura J.; O'Shea, Joseph P.; Müllertz, Anette; Griffin, Brendan T. (2021) 'Exploring porcine gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools'. European Journal of Pharmaceutical Sciences, 161 [DOI] [Full Text] [Details]
(2021) 'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'
Bennett-Lenane, Harriet; O'Shea, Joseph P.; Murray, Jack D.; Ilie, Alexandra-Roxana; Holm, René; Kuentz, Martin; Griffin, Brendan T. (2021) 'Artificial neural networks to predict the apparent degree of supersaturation in supersaturated lipid-based formulations: A pilot study'. Pharmaceutics, 13 (9):1-14 [DOI] [Full Text] [Details]
(2021) 'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'
Bennett-Lenane, Harriet; Griffin, Brendan T.; O'Shea, Joseph P. (2021) 'Machine learning methods for prediction of food effects on bioavailability: A comparison of support vector machines and artificial neural networks'. European Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2021) 'Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (2021) 'Combining species specific in vitro & in silico models to predict in vivo food effect in a preclinical stage – case study of Venetoclax'. European Journal of Pharmaceutical Sciences, 162 [DOI] [Full Text] [Details]
(2020) 'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?'
Bennett-Lenane H.;O'Shea J.P.;O'Driscoll C.M.;Griffin B.T. (2020) 'A Retrospective Biopharmaceutical Analysis of >800 Approved Oral Drug Products: Are Drug Properties of Solid Dispersions and Lipid-Based Formulations Distinctive?'. Journal of Pharmaceutical Sciences, [DOI] [Details]
(2020) 'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide'
Presas E;Tovar S;Cuñarro J;O'Shea JP;O'Driscoll CM; (2020) 'Pre-clinical evaluation of a modified cyclodextrin-based nanoparticle for intestinal delivery of Liraglutide'. Journal of Pharmaceutical Sciences, [DOI] [Details]
(2020) 'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'
Bennett-Lenane, Harriet; Koehl, Niklas J.; O'Dwyer, Patrick J.; Box, Karl J.; O'Shea, Joseph P.; Griffin, Brendan T. (2020) 'Applying computational predictions of biorelevant solubility ratio upon self-emulsifying lipid-based formulations dispersion to predict dose number'. Journal of Pharmaceutical Sciences, [DOI] [Full Text] [Details]
(2019) 'Food for thought: formulating away the food effect - a PEARRL review'
O'Shea JP;Holm R;O'Driscoll CM;Griffin BT; (2019) 'Food for thought: formulating away the food effect - a PEARRL review'. Journal of Pharmacy and Pharmacology, 71 (4) [ Publisher's Version] [DOI] [Full Text] [Details]
(2019) 'Toward the establishment of a standardized pre-clinical porcine model to predict food effects - case studies on Fenofibrate and Paracetamol'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Holm, René; Vertzoni, Maria; Griffin, Brendan T. (2019) 'Toward the establishment of a standardized pre-clinical porcine model to predict food effects - case studies on Fenofibrate and Paracetamol'. International Journal Of Pharmaceutics: X, [ Publisher's Version] [DOI] [Full Text] [Details]
(2019) 'The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review'
Henze, Laura J.; Koehl, Niklas J.; O'Shea, Joseph P.; Kostewicz, Edmund S.; Holm, René; Griffin, Brendan T. (2019) 'The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review'. Journal of Pharmacy and Pharmacology, [Details]
(2017) 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'
Joseph P. O’Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt3, Elisabeth Herbert, Caitriona M. O’Driscoll, Christoph Saal, Dieter Lubda, Brendan T. Griffin, Jennifer B. Dressman (2017) 'Mesoporous silica based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate'. Journal of Pharmacy and Pharmacology, [ Publisher's Version] [DOI] [Details]
(2017) 'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'
McCarthy, CA;Faisal, W;O'Shea, JP;Murphy, C;Ahern, RJ;Ryan, KB;Griffin, BT;Crean, AM (2017) 'In vitro dissolutionmodels for the prediction of in vivo performance of an oral mesoporous silica formulation'. Journal Of Controlled Release, 250 :86-95 [DOI] [Details]
(2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'
Evans, J. C.,Malhotra, M.,Guo, J.,O'Shea, J. P.,Hanrahan, K.,O'Neill, A.,Landry, W. D.,Griffin, B. T.,Darcy, R.,Watson, R. W.,O'Driscoll, C. M. (2016) 'Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo'. Nanomedicine, 12 (8):2341-2351 [ Publisher's Version] [DOI] [Details]
(2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'
O'Shea, JP;Faisal, W;Ruane-O'Hora, T;Devine, KJ;Kostewicz, ES;O'Driscoll, CM;Griffin, BT (2015) 'Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments'. European Journal Of Pharmaceutics And Biopharmaceutics, 96 :207-216 [DOI] [Details]

Professional Associations

  Association Function From / To
Pharmaceutical Society of Ireland Member 01-DEC-13 /
Pharmacists in Industry, Education and Regulatory Committee Member 01-DEC-20 /

Committees

  Committee Function From / To
European Industrial Pharmacists Group (EIPG) Irish Delegate /
Pharmacists in Industry, Education and Regulatory (PIER) Committee Member /

Employment

  Employer Position From / To
EirGen Pharma Ltd Formulation Scientist/ Clinical Affairs Officer 01-NOV-17 / 01-MAR-19
AbbVie Inc Process Scientist 03-MAR-19 / 01-NOV-19
University College Cork Lecturer in Pharmaceutics 01-NOV-19 /

Education

  Year Institution Qualification Subject
2012 University College Cork Bachelor of Pharmacy Pharmacy
2018 University College Cork Doctor of Philosphy Pharmaceutics
2013 Royal College of Surgeons in Ireland Master of Pharmacy Pharmacy
2021 University College Cork Postgraduate Certificate in Teaching and Learning in Higher Education Teaching & Learning